{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T13:46:22Z","timestamp":1761918382307},"reference-count":48,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[1999,8,1]],"date-time":"1999-08-01T00:00:00Z","timestamp":933465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Tubercle and Lung Disease"],"published-print":{"date-parts":[[1999,8]]},"DOI":"10.1054\/tuld.1998.0196","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T11:36:10Z","timestamp":1027683370000},"page":"251-259","source":"Crossref","is-referenced-by-count":63,"title":["Immunogenicity and protective efficacy of DNA vaccines encoding secreted and non-secreted forms of Mycobacterium tuberculosis Ag85A"],"prefix":"10.1054","volume":"79","author":[{"given":"S.L.","family":"Baldwin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.D.","family":"D'Souza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I.M.","family":"Orme","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.A.","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Huygen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"O.","family":"Denis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Tang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Montgomery","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.B.","family":"Ulmer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1054\/tuld.1998.0196_RF1","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1038\/nm0896-893","article-title":"Immunogenicity and protective efficacy of a tuberculosis DNA vaccine","volume":"2","author":"Huygen","year":"1996","journal-title":"Nature Med"},{"key":"10.1054\/tuld.1998.0196_RF2","first-page":"79","article-title":"Research on BCG vaccinination","volume":"21","author":"Ten","year":"1984","journal-title":"Adv Tuberc Res"},{"key":"10.1054\/tuld.1998.0196_RF3","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1093\/infdis\/173.4.800","article-title":"DNA immunization against experimental genital herpes simplex virus infection","volume":"173","author":"Bourne","year":"1996","journal-title":"J Infect Dis"},{"key":"10.1054\/tuld.1998.0196_RF4","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1093\/infdis\/173.3.536","article-title":"Nucleic acid vaccine encoding gD2 protects mice from herpes simplex type 2 disease","volume":"173","author":"Kriesel","year":"1996","journal-title":"J Infect Dis"},{"key":"10.1054\/tuld.1998.0196_RF5","doi-asserted-by":"crossref","first-page":"259","DOI":"10.4049\/jimmunol.155.1.259","article-title":"Genetic immunization against herpes simplex virus. Protection is mediated by CD4+ T lymphocytes","volume":"155","author":"Manickan","year":"1995","journal-title":"J Immunol"},{"key":"10.1054\/tuld.1998.0196_RF6","doi-asserted-by":"crossref","first-page":"11414","DOI":"10.1073\/pnas.93.21.11414","article-title":"Immunization with DNA vaccines encoding glycoprotein D or glycoprotein B, alone or in combination, induces protective immunity in animal models of herpes simplex virus 2 disease","volume":"93","author":"McClements","year":"1996","journal-title":"Proc Natl Acad Sci"},{"key":"10.1054\/tuld.1998.0196_RF7","doi-asserted-by":"crossref","first-page":"5685","DOI":"10.1128\/JVI.68.9.5685-5689.1994","article-title":"Induction in vitro of primary cytotoxic T-lymphocyte responses with DNA encoding herpes simplex virus proteins","volume":"68","author":"Rouse","year":"1994","journal-title":"J Virol"},{"key":"10.1054\/tuld.1998.0196_RF8","doi-asserted-by":"crossref","first-page":"1847","DOI":"10.1093\/hmg\/2.11.1847","article-title":"DNA-based immunization for hepatitis B induces continuous secretion of antigen and high levels of circulating antibody","volume":"2","author":"Davis","year":"1993","journal-title":"Human Molecular Genetics"},{"key":"10.1054\/tuld.1998.0196_RF9","doi-asserted-by":"crossref","first-page":"1447","DOI":"10.1089\/hum.1995.6.11-1447","article-title":"DNA-mediated immunization in mice induces a potent MHC class 1-restricted cytotoxic T lymphocyte response to hepatitis B surface antigen","volume":"6","author":"Davis","year":"1995","journal-title":"Human Gene Therapy"},{"key":"10.1054\/tuld.1998.0196_RF10","doi-asserted-by":"crossref","first-page":"3687","DOI":"10.4049\/jimmunol.156.10.3687","article-title":"DNA immunization induces antibody and cytotoxic T cell responses to hepatitis B core antigen in H-2b mice-","volume":"156","author":"Kuhober","year":"1996","journal-title":"J Immunol"},{"key":"10.1054\/tuld.1998.0196_RF11","doi-asserted-by":"crossref","first-page":"12496","DOI":"10.1073\/pnas.93.22.12496","article-title":"DNA-mediated immunization in a transgenic mouse model of the hepatitis B surface antigen chronic carrier state","volume":"93","author":"Mancini","year":"1996","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1054\/tuld.1998.0196_RF12","doi-asserted-by":"crossref","first-page":"5307","DOI":"10.1073\/pnas.92.12.5307","article-title":"DNA-mediated immunization to the hepatitis B surface antigen in mice: aspects of the humoral response mimic hepatitis B viral infection in humans","volume":"92","author":"Michel","year":"1995","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1054\/tuld.1998.0196_RF13","doi-asserted-by":"crossref","first-page":"5929","DOI":"10.1128\/JVI.69.10.5929-5934.1995","article-title":"Nucleic acid vaccination primes hepatitis B virus surface antigen-specific cytotoxic T lymphocytes in non-responder mice","volume":"69","author":"Schirmbeck","year":"1995","journal-title":"J Virol"},{"key":"10.1054\/tuld.1998.0196_RF14","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.4049\/jimmunol.158.3.1231","article-title":"Enhancement of cellular and humoral immune responses to hepatitis C virus core protein using DNA-based vaccines augmented with cytokine-expressing plasmids","volume":"158","author":"Geissler","year":"1997","journal-title":"J Immunol"},{"key":"10.1054\/tuld.1998.0196_RF15","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1089\/dna.1997.16.185","article-title":"Plasmid DNA expressing a secreted or nonsecreted form of hepatitis C virus nucleocapsid: comparative studies of antibody and T-helper responses following genetic immunization","volume":"16","author":"Inchauspe","year":"1997","journal-title":"DNA Cell Biol"},{"key":"10.1054\/tuld.1998.0196_RF16","doi-asserted-by":"crossref","first-page":"5859","DOI":"10.1128\/JVI.69.9.5859-5863.1995","article-title":"Immune responses to plasmid DNA encoding the hepatitis C virus core protein","volume":"69","author":"Lagging","year":"1995","journal-title":"J Virol"},{"key":"10.1054\/tuld.1998.0196_RF17","doi-asserted-by":"crossref","first-page":"5798","DOI":"10.1128\/JVI.69.9.5798-5805.1995","article-title":"DNA-based immunization with chimeric vectors for the induction of immune responses against the hepatitis C virus nucleocapsid","volume":"69","author":"Major","year":"1995","journal-title":"J Virol"},{"key":"10.1054\/tuld.1998.0196_RF18","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1002\/hep.510240104","article-title":"Expression an immune response to hepatitis C virus core DNA based vaccine constructs","volume":"24","author":"Tokushige","year":"1996","journal-title":"Hepatology"},{"key":"10.1054\/tuld.1998.0196_RF19","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1111\/j.1600-0684.1996.tb00022.x","article-title":"In vivo protective anti-HIV immune responses in non-human primates through DNA immunization","volume":"25","author":"Boyer","year":"1996","journal-title":"J Med Primatol"},{"key":"10.1054\/tuld.1998.0196_RF20","doi-asserted-by":"crossref","first-page":"1433","DOI":"10.1089\/aid.1994.10.1433","article-title":"A qualitative progression in HIV type 1 glycoprotein 120-specific cytotoxic cellular and humoral immune responses in mice receiving a DNA-based glycoprotein 120 vaccine","volume":"10","author":"Fuller","year":"1994","journal-title":"AIDS Res Hum Retroviruses"},{"key":"10.1054\/tuld.1998.0196_RF21","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1089\/dna.1993.12.799","article-title":"DNA inoculation induces neutralizing immune responses against human immunodeficiency virus type 1 in mice and nonhuman primates","volume":"12","author":"Wang","year":"1993","journal-title":"DNA Cell Biol"},{"key":"10.1054\/tuld.1998.0196_RF22","doi-asserted-by":"crossref","first-page":"4156","DOI":"10.1073\/pnas.90.9.4156","article-title":"Gene inoculation generates immune responses against human immunodeficiency virus type 1","volume":"90","author":"Wang","year":"1993","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1054\/tuld.1998.0196_RF23","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1006\/viro.1995.1383","article-title":"Induction of humoral and cellular immune responses to the human immunodeficiency Type 1 virus in nonhuman primates in vivo DNA inoculation","volume":"211","author":"Wang","year":"1995","journal-title":"Virology"},{"key":"10.1054\/tuld.1998.0196_RF24","doi-asserted-by":"crossref","first-page":"1534","DOI":"10.1016\/0264-410X(94)90079-5","article-title":"Genetic vaccination against leishmaniasis","volume":"12","author":"Xu","year":"1994","journal-title":"Vaccine"},{"key":"10.1054\/tuld.1998.0196_RF25","first-page":"173","article-title":"Protection against leishmaniasis by injection of DNA encoding a major surface glycoprotein gp63 of L. major","volume":"84","author":"Xu","year":"1995","journal-title":"Immunol"},{"key":"10.1054\/tuld.1998.0196_RF26","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1093\/infdis\/175.1.91","article-title":"An OspA-based DNA vaccine protects mice against infection with Borrelia burgdorferi","volume":"175","author":"Luke","year":"1997","journal-title":"J Infect Dis"},{"key":"10.1054\/tuld.1998.0196_RF27","doi-asserted-by":"crossref","first-page":"2831","DOI":"10.1002\/eji.1830261206","article-title":"Protective immunization with plasmid DNA containing the outer surface lipoprotein A gene of Borrelia burgdorferi is independent of an eukaryotic promoter","volume":"26","author":"Simon","year":"1996","journal-title":"Eur J Immunol"},{"key":"10.1054\/tuld.1998.0196_RF28","doi-asserted-by":"crossref","first-page":"2749","DOI":"10.1002\/eji.1830261130","article-title":"Plasmid DNA and protein vaccination of mice to the outer surface protein A of Borrelia burgdorferi leads to induction of T helper cells with specificity for a major epitope and augmentation of protective IgG antibodies in vivo","volume":"26","author":"Zhong","year":"1996","journal-title":"Eur J Immunol"},{"key":"10.1054\/tuld.1998.0196_RF29","doi-asserted-by":"crossref","first-page":"1537","DOI":"10.1016\/0264-410X(94)90080-9","article-title":"Towards a DNA vaccine against tuberculosis","volume":"12","author":"Lowrie","year":"1994","journal-title":"Vaccine"},{"key":"10.1054\/tuld.1998.0196_RF30","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1016\/S0264-410X(97)00073-X","article-title":"Protection against tuberculosis by a plasmid DNA vaccine","volume":"15","author":"Lowrie","year":"1997","journal-title":"Vaccine"},{"key":"10.1054\/tuld.1998.0196_RF31","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1016\/S0264-410X(96)00274-5","article-title":"Immunogenicity and efficacy of a tuberculosis DNA vaccine encoding the components of the secreted antigen 85 complex","volume":"15","author":"Lozes","year":"1997","journal-title":"Vaccine"},{"key":"10.1054\/tuld.1998.0196_RF32","first-page":"843","article-title":"New vaccines against tuberculosis","volume":"28","author":"Silva","year":"1995","journal-title":"Braz J Med Biol Res"},{"key":"10.1054\/tuld.1998.0196_RF33","doi-asserted-by":"crossref","first-page":"2400","DOI":"10.1128\/IAI.64.7.2400-2407.1996","article-title":"Characterization of T cells that confer a high degree of protective immunity against tuberculosis in mice after vaccination with tumor cells expressing hsp65","volume":"64","author":"Silva","year":"1996","journal-title":"Infect Immun"},{"key":"10.1054\/tuld.1998.0196_RF34","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1038\/nm0896-888","article-title":"Vaccination against tuberculosis by DNA injection","volume":"2","author":"Tascon","year":"1996","journal-title":"Nat Med"},{"key":"10.1054\/tuld.1998.0196_RF35","doi-asserted-by":"crossref","first-page":"5921","DOI":"10.4049\/jimmunol.158.12.5921","article-title":"Functions and specificity of T Cells following nucleic acid vaccination of mice against Mycobacterium tuberculosis infection","volume":"158","author":"Zhu","year":"1997","journal-title":"J Immunol"},{"key":"10.1054\/tuld.1998.0196_RF36","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1146\/annurev.immunol.15.1.617","article-title":"DNA vaccines [Review]","volume":"15","author":"Donnelly","year":"1997","journal-title":"Ann Rev Immunology"},{"key":"10.1054\/tuld.1998.0196_RF37","doi-asserted-by":"crossref","first-page":"1420","DOI":"10.1126\/science.276.5317.1420","article-title":"Role of the major antigen of Mycobacterium tuberculosis in cell wall biogenesis","volume":"276","author":"Belisle","year":"1997","journal-title":"Science"},{"key":"10.1054\/tuld.1998.0196_RF38","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1128\/MR.56.4.648-661.1992","article-title":"The Antigen 85 complex: a major secretion product of Mycobacterium tuberculosis","volume":"56","author":"Wiker","year":"1992","journal-title":"Microb Reviews"},{"key":"10.1054\/tuld.1998.0196_RF39","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.1128\/IAI.66.4.1527-1533.1998","article-title":"Vaccination with plasmid DNA encoding antigen 85A stimulates a CD4+ and CD8+ T-Cell epitope repertoire broader than stimulated by M. tuberculosis H37Rv infection","volume":"66","author":"Denis","year":"1998","journal-title":"Infect Immun"},{"key":"10.1054\/tuld.1998.0196_RF40","first-page":"285","article-title":"Induction of humoral and cellular immune responses by vaccination with M. tuberculosis antigen 85 DNA","volume":"43","author":"Montgomery","year":"1997","journal-title":"Cell Mol Biol"},{"key":"10.1054\/tuld.1998.0196_RF41","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1016\/S0264-410X(96)00255-1","article-title":"Expression and immunogenicity of M. tuberculosis antigen 85 by DNA vaccination","volume":"15","author":"Ulmer","year":"1997","journal-title":"Vaccine"},{"key":"10.1054\/tuld.1998.0196_RF42","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1038\/sj.gt.3300380","article-title":"Immune-mediated destruction of transfected muscle fibers after direct gene transfer with antigen-expressing plasmid DNA","volume":"4","author":"Davis","year":"1997","journal-title":"Gene-Ther"},{"key":"10.1054\/tuld.1998.0196_RF43","doi-asserted-by":"crossref","unstructured":"Griffin, J, P, Orme, I, M, Evolution of CD4 T-cell subsets following infection of naive and memory immune mice with Mycobacterium tuberculosis, Infect Immun, 62, 1683, 1690","DOI":"10.1128\/IAI.62.5.1683-1690.1994"},{"key":"10.1054\/tuld.1998.0196_RF44","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1038\/374546a0","article-title":"CpG motifs in bacterial DNA trigger direct B-cell activation","volume":"374","author":"Krieg","year":"1995","journal-title":"Nature"},{"key":"10.1054\/tuld.1998.0196_RF45","doi-asserted-by":"crossref","first-page":"1759","DOI":"10.4049\/jimmunol.147.6.1759","article-title":"Stimulation of in vitro murine lymphocyte proliferation by bacterial DNA","volume":"147","author":"Messina","year":"1991","journal-title":"J Immunol"},{"key":"10.1054\/tuld.1998.0196_RF46","doi-asserted-by":"crossref","first-page":"4072","DOI":"10.4049\/jimmunol.148.12.4072","article-title":"Unique palindromic sequences in synthetic oligonucleotides are required to induce IFN and augment IFN-mediated natural killer activity","volume":"148","author":"Yamamoto","year":"1992","journal-title":"J Immunol"},{"key":"10.1054\/tuld.1998.0196_RF47","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/0008-8749(84)90082-0","article-title":"Adoptive protection of the Mycobacterium tuberculosis\u2013 infected lung: dissociation between cells that passively transfer protective immunity and those that transfer delayed-type hypersensitivity to tuberculin","volume":"84","author":"Orme","year":"1984","journal-title":"Cellular Immunology"},{"key":"10.1054\/tuld.1998.0196_RF48","doi-asserted-by":"crossref","first-page":"2243","DOI":"10.1084\/jem.178.6.2243","article-title":"Disseminated tuberculosis in interferon \u03b3 gene-disrupted mice","volume":"178","author":"Cooper","year":"1993","journal-title":"J Exp Med"}],"container-title":["Tubercle and Lung Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0962847998901964?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0962847998901964?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,4,22]],"date-time":"2023-04-22T05:53:19Z","timestamp":1682142799000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0962847998901964"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999,8]]},"references-count":48,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1999,8]]}},"alternative-id":["S0962847998901964"],"URL":"https:\/\/doi.org\/10.1054\/tuld.1998.0196","relation":{},"ISSN":["0962-8479"],"issn-type":[{"value":"0962-8479","type":"print"}],"subject":[],"published":{"date-parts":[[1999,8]]}}}