{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T15:04:15Z","timestamp":1774364655478,"version":"3.50.1"},"reference-count":16,"publisher":"Georg Thieme Verlag KG","issue":"01","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Appl Clin Inform"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Objective\u2003The aim of the study is to implement a customized QTc interval clinical decision support (CDS) alert strategy in our electronic health record for hospitalized patients and aimed at providers with the following objectives: minimize QTc prolongation, minimize exposure to QTc prolonging medications, and decrease overall QTc-related alerts. A strategy that was based on the validated QTc risk scoring tool and replacing medication knowledge vendor alerts with custom QTc prolongation alerts was implemented.<\/jats:p><jats:p>\n          Methods\u2003This is a retrospective quasi-experimental study with a pre-intervention period (August 2019 to October 2019) and post-intervention period (December 2019 to February 2020). The custom alert was implemented in November 2019.<\/jats:p><jats:p>\n          Results\u2003In the pre-implementation group, 361 (19.3%) patients developed QTc prolongation, and in the post-implementation group, 357 (19.6%) patients developed QTc prolongation (OR: 1.02, 95% CI: 0.87\u20131.20, p\u2009=\u20090.81). The odds ratio of an action taken post-implementation compared with pre-implementation was 18.90 (95% CI: 14.03\u201325.47, p &lt;0. 001). There was also a decrease in total orders for QTc prolonging medications from 7,921 (5.5%) to 7,566 (5.3%) with an odds ratio of 0.96 (95% CI: 0.93\u20130.99, p\u2009=\u20090.01).<\/jats:p><jats:p>\n          Conclusion\u2003We were able to decrease patient exposure to QTc prolonging medications while not increasing the rate of QTc prolongation as well as improving alert action rate. Additionally, there was a decrease in QTc prolonging medication orders which illustrates the benefit of using a validated risk score with a customized CDS approach compared with a traditional vendor-based strategy. Further research is needed to confirm if an approach implemented at our organization can reduce QTc prolongation rates.<\/jats:p>","DOI":"10.1055\/s-0041-1740483","type":"journal-article","created":{"date-parts":[[2022,1,5]],"date-time":"2022-01-05T23:37:37Z","timestamp":1641425857000},"page":"019-029","source":"Crossref","is-referenced-by-count":6,"title":["Effect of Replacing Vendor QTc Alerts with a Custom QTc Risk Alert in Inpatients"],"prefix":"10.1055","volume":"13","author":[{"given":"Steven","family":"Stettner","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, New York-Presbyterian\/Weill Cornell Medical Center, New York, New York, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah","family":"Adie","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Services, Michigan Medicine, Ann Arbor, Michigan, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah","family":"Hanigan","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Services, Michigan Medicine, Ann Arbor, Michigan, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Thomas","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine-Cardiology, Michigan Medicine, Ann Arbor, Michigan, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristen","family":"Pogue","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Services, Michigan Medicine, Ann Arbor, Michigan, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher","family":"Zimmerman","sequence":"additional","affiliation":[{"name":"Department of Health Information and Technology Services, Michigan Medicine, Ann Arbor, Michigan, United 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