{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T05:49:17Z","timestamp":1776404957821,"version":"3.51.2"},"reference-count":27,"publisher":"Georg Thieme Verlag KG","issue":"01","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Appl Clin Inform"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Objectives\u2003An electronic clinical decision support (CDS) alert can provide real-time provider support to offer pre-exposure prophylaxis (PrEP) to youth at risk for human immunodeficiency virus (HIV). The purpose of this study was to evaluate provider utilization of a PrEP CDS alert in a large academic-community pediatric network and assess the association of the alert with PrEP prescribing rates.<\/jats:p><jats:p>\n          Methods\u2003HIV test orders were altered for patients 13 years and older to include a hard-stop prompt asking if the patient would benefit from PrEP. If providers answered \u201cYes\u201d or \u201cNot Sure,\u201d the CDS alert launched with options to open a standardized order set, refer to an internal PrEP specialist, and\/or receive an education module. We analyzed provider utilization using a frequency analysis. The rate of new PrEP prescriptions for 1 year after CDS alert implementation was compared with the year prior using Fisher's exact test.<\/jats:p><jats:p>\n          Results\u2003Of the 56 providers exposed to the CDS alert, 70% (n\u2009=\u200939) responded \u201cNot sure\u201d to the alert prompt asking if their patient would benefit from PrEP, and 54% (n\u2009=\u200930) chose at least one clinical support tool. The PrEP prescribing rate increased from 2.3 prescriptions per 10,000 patients to 6.6 prescriptions per 10,000 patients in the year post-intervention (p\u2009=\u20090.02).<\/jats:p><jats:p>\n          Conclusion\u2003Our findings suggest a knowledge gap among pediatric providers in identifying patients who would benefit from PrEP. A hard-stop prompt within an HIV test order that offers CDS and provider education might be an effective tool to increase PrEP prescribing among pediatric providers.<\/jats:p>","DOI":"10.1055\/s-0041-1740484","type":"journal-article","created":{"date-parts":[[2022,1,12]],"date-time":"2022-01-12T23:55:08Z","timestamp":1642031708000},"page":"030-036","source":"Crossref","is-referenced-by-count":12,"title":["Pediatric Provider Utilization of a Clinical Decision Support Alert and Association with HIV Pre-exposure Prophylaxis Prescription Rates"],"prefix":"10.1055","volume":"13","author":[{"given":"Carrie T.","family":"Chan","sequence":"additional","affiliation":[{"name":"Center for Adolescent Health, Lucile Packard Children's Hospital, Palo Alto, California, United States"},{"name":"Department of Family Health Care Nursing, University of California San Francisco, San Francisco, California, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Megen","family":"Vo","sequence":"additional","affiliation":[{"name":"Department of Pediatrics\u2014Adolescent Medicine, Stanford University School of Medicine, Palo Alto, California, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer","family":"Carlson","sequence":"additional","affiliation":[{"name":"Department of Pediatrics\u2014Adolescent Medicine, Stanford University School of Medicine, Palo Alto, California, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tzielan","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Pediatrics \u2014 Rheumatology, Stanford University School of Medicine, Palo Alto, California, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcello","family":"Chang","sequence":"additional","affiliation":[{"name":"Stanford University School of Medicine, Stanford, California, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Geoffrey","family":"Hart-Cooper","sequence":"additional","affiliation":[{"name":"Stanford Children's Health, Menlo Park, California, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2022,1,12]]},"reference":[{"issue":"48","key":"ref7","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.15585\/mmwr.mm6848e1","article-title":"Vital signs: status of human immunodeficiency virus testing, viral suppression, and HIV preexposure prophylaxis\u2014United States, 2013-2018","volume":"68","author":"N S Harris","year":"2019","journal-title":"Morb Mortal Wkly Rep"},{"issue":"11","key":"ref8","doi-asserted-by":"crossref","first-page":"2926","DOI":"10.1007\/s10461-019-02545-1","article-title":"HIV-related training and correlates of knowledge, HIV screening and prescribing of nPEP and PrEP among primary care providers in Southeast United States, 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