{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T14:13:28Z","timestamp":1784816008861,"version":"3.55.0"},"reference-count":0,"publisher":"Georg Thieme Verlag KG","issue":"08","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Drug Res (Stuttg)"],"published-print":{"date-parts":[[2018,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\nObjectives  This study was carried out to investigate the neurobehavioral properties of naringin, a flavonoid compound formed from naringenin on behavioral models in mice.<\/jats:p><jats:p>\nMethod  The neurobehavioral property of naringin (2.5, 5 and 10\u2009mg\/kg) administered intraperitoneally (i.p.) was assessed on novelty-induced rearing, locomotor behavior using open field test; anxiolytic effect was evaluated using hole-board, light and dark box, and elevated-plus maze paradigms. The anti-depressant-like property was also assessed using forced swim test (FST), tail suspension test (TST) and social interaction test (SIT). The cognitive enhancing effect of naringin was evaluated using Y-maze test.<\/jats:p><jats:p>\nResults  Intraperitoneal administration of naringin (2.5 and 5\u2009mg\/kg) demonstrated significant (p&lt;0.05) increase in rearing behavior but not the spontaneous motor activity in comparison to control. In the anti-depressant test, naringin (2.5, 5 and 10\u2009mg\/kg, i.p.) significantly decreased the duration of immobility in the FST and TST, and increased the % social interaction preference in the SIT relative to controls, suggesting anti-depressant-like and increased social behaviors. Moreover, naringin also exhibited anxiolytic and memory enhancing properties in mice.<\/jats:p><jats:p>\nConclusion  These findings suggest that naringin possesses anti-depressant- and anxiolytic-like activities as well as memory enhancing effect in mice.<\/jats:p>","DOI":"10.1055\/a-0575-3730","type":"journal-article","created":{"date-parts":[[2018,3,12]],"date-time":"2018-03-12T23:44:20Z","timestamp":1520898260000},"page":"465-474","source":"Crossref","is-referenced-by-count":23,"title":["Evaluation of the Neurobehavioral Properties of Naringin in Swiss Mice"],"prefix":"10.1055","volume":"68","author":[{"given":"Benneth","family":"Ben-Azu","sequence":"additional","affiliation":[{"name":"Neuropharmacology Unit, Department of Pharmacology and Therapeutics, College of Medicine, University of Ibadan, Ibadan, Oyo State, Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ekene","family":"Nwoke","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Therapeutics, Faculty of Basic Medical Sciences, Delta State University, Abraka, Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Solomon","family":"Umukoro","sequence":"additional","affiliation":[{"name":"Neuropharmacology Unit, Department of Pharmacology and Therapeutics, College of Medicine, University of Ibadan, Ibadan, Oyo State, Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adegbuyi","family":"Aderibigbe","sequence":"additional","affiliation":[{"name":"Neuropharmacology Unit, Department of Pharmacology and Therapeutics, College of Medicine, University of Ibadan, Ibadan, Oyo State, Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abayomi","family":"Ajayi","sequence":"additional","affiliation":[{"name":"Neuropharmacology Unit, Department of Pharmacology and Therapeutics, College of Medicine, University of Ibadan, Ibadan, Oyo State, Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ezekiel","family":"Iwalewa","sequence":"additional","affiliation":[{"name":"Neuropharmacology Unit, Department of Pharmacology and Therapeutics, College of Medicine, University of Ibadan, Ibadan, Oyo State, Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2018,3,12]]},"container-title":["Drug Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-0575-3730.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,7,26]],"date-time":"2018-07-26T09:40:23Z","timestamp":1532598023000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-0575-3730"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,3,12]]},"references-count":0,"journal-issue":{"issue":"08","published-online":{"date-parts":[[2018,7,25]]},"published-print":{"date-parts":[[2018,8]]}},"URL":"https:\/\/doi.org\/10.1055\/a-0575-3730","relation":{},"ISSN":["2194-9379","2194-9387"],"issn-type":[{"value":"2194-9379","type":"print"},{"value":"2194-9387","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,3,12]]}}}