{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T17:48:04Z","timestamp":1778694484338,"version":"3.51.4"},"reference-count":32,"publisher":"Georg Thieme Verlag KG","issue":"05","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Z Gastroenterol"],"published-print":{"date-parts":[[2018,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Anal intraepithelial neoplasia (AIN) is a precursor of anal carcinoma. Conventional therapy is based on topical and local ablative approaches. However, the recurrence rates are very high, leading to repetitive treatment sessions and need for long-term surveillance. Endoscopic submucosal dissection (ESD) is an established treatment for malignant early neoplasias of the gastrointestinal tract, especially in the esophagus, stomach, and colorectum. Japanese centers have reported few cases of ESD for early anal carcinoma. We report a case of high-grade AIN diagnosed with magnifying narrow-band imaging and chromoendoscopy that was resected R0 with ESD en bloc.<\/jats:p>","DOI":"10.1055\/a-0578-9059","type":"journal-article","created":{"date-parts":[[2018,5,7]],"date-time":"2018-05-07T22:48:13Z","timestamp":1525733293000},"page":"495-498","source":"Crossref","is-referenced-by-count":5,"title":["Endoscopic submucosal dissection (ESD) for anal high-grade intraepithelial neoplasia: a case report"],"prefix":"10.1055","volume":"56","author":[{"given":"Daniel","family":"Neureiter","sequence":"first","affiliation":[{"name":"Institute of Pathology, Paracelsus Medical University\/Salzburger Landeskliniken (SALK), Salzburg, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Josef","family":"Holzinger","sequence":"first","affiliation":[{"name":"Department of Surgery, Paracelsus Medical University\/Salzburger Landeskliniken (SALK), Salzburg, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tobias","family":"Kiesslich","sequence":"first","affiliation":[{"name":"Laboratory for Tumour Biology and Experimental Therapies (TREAT), Institute of Physiology and Pathophysiology, Paracelsus Medical University, Salzburg, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eckhard","family":"Klieser","sequence":"first","affiliation":[{"name":"Institute of Pathology, Paracelsus Medical University\/Salzburger Landeskliniken (SALK), Salzburg, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frieder","family":"Berr","sequence":"first","affiliation":[{"name":"Department of Internal Medicine I, Paracelsus Medical University\/Salzburger Landeskliniken (SALK), Salzburg, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrej","family":"Wagner","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine I, Paracelsus Medical University\/Salzburger Landeskliniken (SALK), Salzburg, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2018,5,7]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"2892","DOI":"10.1002\/cncr.23744","article-title":"Understanding the burden of human papillomavirus-associated anal cancers in the US","volume":"113","author":"D A Joseph","year":"2008","journal-title":"Cancer"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"10","DOI":"10.3322\/caac.20138","article-title":"Cancer statistics, 2012","volume":"62","author":"R Siegel","year":"2012","journal-title":"CA Cancer J\u00a0Clin"},{"key":"ref3","first-page":"417","volume-title":"Premalignent lesions of the digestive system","author":"R D Odze","year":"2010"},{"key":"ref4","first-page":"1014","article-title":"Detection of human papillomavirus DNA in anal intraepithelial neoplasia and anal cancer","volume":"51","author":"J M Palefsky","year":"1991","journal-title":"Cancer Res"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"50","DOI":"10.4251\/wjgo.v9.i2.50","article-title":"Anal intraepithelial neoplasia: A review of diagnosis and management","volume":"9","author":"J R Roberts","year":"2017","journal-title":"World J Gastrointest Oncol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/S1470-2045(12)70080-3","article-title":"Anal human papillomavirus infection and associated neoplastic lesions in men who have sex with men: a systematic review and meta-analysis","volume":"13","author":"D A Machalek","year":"2012","journal-title":"Lancet Oncol"},{"key":"ref7","first-page":"31","article-title":"Anal intraepitelial neoplasia: a narrative review","volume":"108","author":"G Elorza","year":"2016","journal-title":"Rev Esp Enferm Dig"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1111\/j.1445-2197.2006.03837.x","article-title":"Malignant progression of anal intra-epithelial neoplasia","volume":"76","author":"A J Watson","year":"2006","journal-title":"ANZ J Surg"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1002\/bjs.4994","article-title":"Malignant transformation of high-grade anal intraepithelial neoplasia","volume":"92","author":"J H Scholefield","year":"2005","journal-title":"Br J Surg"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1086\/505219","article-title":"Screening HIV-infected individuals for anal cancer precursor lesions: a systematic review","volume":"43","author":"E Y Chiao","year":"2006","journal-title":"Clin Infect Dis"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1097\/LGT.0000000000000064","article-title":"Which lesions should be biopsied during high-resolution anoscopy? 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