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In this review, we discuss the roles of imaging examinations, and illustrate new insights into genotype-imaging phenotype relationships.<\/jats:p>","DOI":"10.1055\/a-0586-3710","type":"journal-article","created":{"date-parts":[[2018,4,4]],"date-time":"2018-04-04T22:50:39Z","timestamp":1522882239000},"page":"414-418","source":"Crossref","is-referenced-by-count":3,"title":["Diagnostic Investigation of Lesions Associated with Succinate Dehydrogenase Defects"],"prefix":"10.1055","volume":"51","author":[{"given":"David","family":"Ta\u00efeb","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, La Timone University Hospital, CERIMED, Aix-Marseille University, Marseille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henri","family":"Timmers","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Endocrinology, Radboud University Medical Centre, Nijmegen, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karel","family":"Pacak","sequence":"additional","affiliation":[{"name":"Section on Medical Neuroendocrinology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2018,4,4]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1016\/j.mod.2012.11.004","article-title":"Resolved and open issues in chromaffin cell development","volume":"130","author":"K Unsicker","year":"2013","journal-title":"Mech Dev"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1210\/er.2017-00062","article-title":"New perspectives on pheochromocytoma and paraganglioma: Towards a molecular classification","volume":"38","author":"J Crona","year":"2017","journal-title":"Endocr Rev"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.ccell.2017.01.001","article-title":"Comprehensive molecular characterization of pheochromocytoma and paraganglioma","volume":"31","author":"L Fishbein","year":"2017","journal-title":"Cancer Cell"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1126\/science.287.5454.848","article-title":"Mutations in SDHD, a mitochondrial complex II gene, in hereditary paraganglioma","volume":"287","author":"B E Baysal","year":"2000","journal-title":"Science"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1038\/81551","article-title":"Mutations in SDHC cause autosomal dominant paraganglioma, type 3","volume":"26","author":"S Niemann","year":"2000","journal-title":"Nat Genet"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1086\/321282","article-title":"Gene mutations in the succinate dehydrogenase subunit SDHB cause susceptibility to familial pheochromocytoma and to familial paraganglioma","volume":"69","author":"D Astuti","year":"2001","journal-title":"Am J Hum Genet"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"3011","DOI":"10.1093\/hmg\/ddq206","article-title":"SDHA is a tumor suppressor gene causing paraganglioma","volume":"19","author":"N Burnichon","year":"2010","journal-title":"Hum Mol Genet"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1126\/science.1175689","article-title":"SDH5, a gene required for flavination of succinate dehydrogenase, is mutated in paraganglioma","volume":"325","author":"H X Hao","year":"2009","journal-title":"Science"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1530\/ERC-14-0254","article-title":"Aberrant DNA hypermethylation of SDHC: A novel mechanism of tumor development in Carney triad","volume":"21","author":"F Haller","year":"2014","journal-title":"Endocr Relat Cancer"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1038\/nature11986","article-title":"Succinate is an inflammatory signal that induces IL-1beta through HIF-1alpha","volume":"496","author":"G M Tannahill","year":"2013","journal-title":"Nature"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"13174","DOI":"10.18632\/oncotarget.14485","article-title":"Oncometabolite succinate promotes angiogenesis by upregulating VEGF expression through GPR91-mediated STAT3 and ERK activation","volume":"8","author":"X Mu","year":"2017","journal-title":"Oncotarget"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"T91","DOI":"10.1530\/ERC-15-0268","article-title":"15 YEARS OF PARAGANGLIOMA: Clinical manifestations of paraganglioma syndromes types 1-5","volume":"22","author":"D E Benn","year":"2015","journal-title":"Endocr Relat Cancer"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"2057","DOI":"10.1001\/jama.294.16.2057","article-title":"European-American Paraganglioma Study G. 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