{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T16:27:53Z","timestamp":1764174473625},"reference-count":0,"publisher":"Georg Thieme Verlag KG","issue":"03","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Klin Padiatr"],"published-print":{"date-parts":[[2018,5]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title><jats:p>Die vorliegenden Empfehlungen der internationalen Beckwith-Wiedemann-Syndrom (BWS\/BWSp)-Konsensus-Gruppe stellen einen Rahmen f\u00fcr die Verbesserung der Diagnostik und der klinischen Begleitung bei Patienten des BWSp dar. Hierbei ist den komplexen genetischen Basismechanismen und den variablen Multisystem-Ph\u00e4notypen des BWSp dahingehend Rechnung zu tragen, dass ein verantwortlicher klinischer Ansprechpartner die notwendige Koordination der unterschiedlichen Aspekte f\u00fcr den einzelnen Patienten \u00fcbernimmt. Die vorgeschlagenen diagnostischen und medizinischen Empfehlungen sollen hierbei praktikabel und kosten-effektiv gestaltet sein. Nichtsdestotrotz sind auf dem Hintergrund der sehr unterschiedlichen Gesundheitssysteme und medizinrechtlichen Vorgaben weitere Datenerhebungen wichtig, um tats\u00e4chlich auf lange Sicht die besten Strategien, z.\u2009B. in der Tumorfr\u00fcherkennnung, allgemein g\u00fcltig empfehlen zu k\u00f6nnen. Daher m\u00fcssen die hier gegebenen Konsensus-Empfehlungen im Rahmen prospektiver Studien evaluiert und weiteren zuk\u00fcnftigen Konsensus-Initiativen zur Evidenz-basierten \u00dcberpr\u00fcfung vorgelegt werden.<\/jats:p>","DOI":"10.1055\/a-0591-9479","type":"journal-article","created":{"date-parts":[[2018,4,16]],"date-time":"2018-04-16T22:48:17Z","timestamp":1523918897000},"page":"151-159","source":"Crossref","is-referenced-by-count":9,"title":["Beckwith-Wiedemann-Syndrom (BWS): Aktueller Stand der Diagnostik und des klinischen Managements"],"prefix":"10.1055","volume":"230","author":[{"given":"Miriam","family":"Elbracht","sequence":"additional","affiliation":[{"name":"Human Genetics, University Hospital, RWTH Aachen, Aachen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dirk","family":"Prawitt","sequence":"additional","affiliation":[{"name":"Kinder- und Jugendmedizin, Universit\u00e4tsmedizin Mainz, Mainz, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rebekka","family":"Nemetschek","sequence":"additional","affiliation":[{"name":"Pediatric Hematology\/Oncology, Hannover Medical School, Hannover, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Kratz","sequence":"additional","affiliation":[{"name":"Pediatric Hematology\/Oncology, Hannover Medical School, Hannover, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Eggermann","sequence":"additional","affiliation":[{"name":"Human Genetics, University Hospital, RWTH Aachen, Aachen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2018,4,16]]},"container-title":["Klinische P\u00e4diatrie"],"original-title":[],"language":"de","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-0591-9479.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,5,8]],"date-time":"2018-05-08T22:31:45Z","timestamp":1525818705000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-0591-9479"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,4,16]]},"references-count":0,"journal-issue":{"issue":"03","published-online":{"date-parts":[[2018,5,8]]},"published-print":{"date-parts":[[2018,4]]}},"URL":"https:\/\/doi.org\/10.1055\/a-0591-9479","relation":{},"ISSN":["0300-8630","1439-3824"],"issn-type":[{"value":"0300-8630","type":"print"},{"value":"1439-3824","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,4,16]]}}}