{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T22:58:47Z","timestamp":1769122727996,"version":"3.49.0"},"reference-count":0,"publisher":"Georg Thieme Verlag KG","issue":"04","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ultraschall in Med"],"published-print":{"date-parts":[[2019,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Objective\u2002To construct prenatal age-specific reference intervals for sonographic measurements of the optic nerve sheath diameter (ONSD) during gestation in normal fetuses.<\/jats:p><jats:p>\n          Materials and Methods\u2002Prospective cross-sectional study of fetuses assessed in antenatal ultrasound units between 2010 and 2014. The examination was based on a technique for the sonographic assessment of ONSD previously published by our group.\u200aThe mean values and SDs of the ONSD were modeled as a function of the gestational week by curve estimation analysis based on the highest adjusted R2 coefficient. Repeatability tests were performed to assess intraobserver variability and interobserver agreement.<\/jats:p><jats:p>\n          Results\u2002During the study period 364 healthy fetuses were enrolled. The mean values for the ONSD varied from 0.6\u200amm at 15\u201316 weeks to 2.8\u200amm at 37\u201338 weeks. The ONSD grows in a linear fashion throughout gestation, with a quadratic equation providing an optimal fit to the data (adjusted R2\u200a=\u200a0.957).<\/jats:p><jats:p>\n          Conclusion\u2002Sonographic age-specific references for the fetal ONSD are presented. This data may assist in the decision-making process in fetuses with a suspected increase in intracranial pressure, or anomalies affecting the development of optic stalks, such as optic hypoplasia and septo-optic dysplasia.<\/jats:p>","DOI":"10.1055\/a-0594-2053","type":"journal-article","created":{"date-parts":[[2018,6,7]],"date-time":"2018-06-07T23:03:53Z","timestamp":1528412633000},"page":"476-480","source":"Crossref","is-referenced-by-count":8,"title":["Ultrasound Nomograms of the Fetal Optic Nerve Sheath Diameter"],"prefix":"10.1055","volume":"40","author":[{"given":"Karina Krajden","family":"Haratz","sequence":"additional","affiliation":[{"name":"Ultrasound in ObGyn Unit and Fetal Neurology Clinic, Department of Obstetrics and Gynecology, Wolfson Medical Center, Holon, Israel"},{"name":"Affiliated with the Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yaakov","family":"Melcer","sequence":"additional","affiliation":[{"name":"Affiliated with the Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel"},{"name":"Department of Obstetrics and Gynecology, Assaf Harofeh Medical Center, Zerifin, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zvi","family":"Leibovitz","sequence":"additional","affiliation":[{"name":"Ultrasound in ObGyn Unit and Fetal Neurology Clinic, Department of Obstetrics and Gynecology, Wolfson Medical Center, Holon, Israel"},{"name":"Ultrasound in ObGyn Unit, Bnai Zion Medical Center, Haifa, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hagit","family":"Feit","sequence":"additional","affiliation":[{"name":"Ultrasound in ObGyn Unit and Fetal Neurology Clinic, Department of Obstetrics and Gynecology, Wolfson Medical Center, Holon, Israel"},{"name":"Affiliated with the Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tally","family":"Lerman-Sagie","sequence":"additional","affiliation":[{"name":"Ultrasound in ObGyn Unit and Fetal Neurology Clinic, Department of Obstetrics and Gynecology, Wolfson Medical Center, Holon, Israel"},{"name":"Affiliated with the Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel"},{"name":"Pediatric Neurology Unit, Wolfson Medical Center, Holon, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dorit","family":"Lev","sequence":"additional","affiliation":[{"name":"Ultrasound in ObGyn Unit and Fetal Neurology Clinic, Department of Obstetrics and Gynecology, Wolfson Medical Center, Holon, Israel"},{"name":"Affiliated with the Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel"},{"name":"Genetics Institute, Wolfson Medical Center, Holon, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shimon","family":"Ginath","sequence":"additional","affiliation":[{"name":"Ultrasound in ObGyn Unit and Fetal Neurology Clinic, Department of Obstetrics and Gynecology, Wolfson Medical Center, Holon, Israel"},{"name":"Affiliated with the Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liat","family":"Gindes","sequence":"additional","affiliation":[{"name":"Ultrasound in ObGyn Unit and Fetal Neurology Clinic, Department of Obstetrics and Gynecology, Wolfson Medical Center, Holon, Israel"},{"name":"Affiliated with the Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio Fernandes","family":"Moron","sequence":"additional","affiliation":[{"name":"Fetal Medicine Discipline, Department of Obstetrics, Federal University of Sao Paulo, Sao Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gustavo","family":"Malinger","sequence":"additional","affiliation":[{"name":"Affiliated with the Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel"},{"name":"Division of Ultrasound in Obstetrics and Gynecology, Lis Maternity Hospital, Tel Aviv Sourasky Medical Center, Tel-Aviv, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2018,6,7]]},"container-title":["Ultraschall in der Medizin - European Journal of Ultrasound"],"original-title":[],"language":"de","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-0594-2053.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,5]],"date-time":"2019-08-05T22:33:36Z","timestamp":1565044416000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-0594-2053"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,6,7]]},"references-count":0,"journal-issue":{"issue":"04","published-online":{"date-parts":[[2019,8,5]]},"published-print":{"date-parts":[[2019,8]]}},"URL":"https:\/\/doi.org\/10.1055\/a-0594-2053","relation":{},"ISSN":["0172-4614","1438-8782"],"issn-type":[{"value":"0172-4614","type":"print"},{"value":"1438-8782","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,6,7]]}}}