{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T19:31:23Z","timestamp":1779910283214,"version":"3.53.1"},"reference-count":0,"publisher":"Georg Thieme Verlag KG","issue":"08","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Fortschr R\u00f6ntgenstr"],"published-print":{"date-parts":[[2018,8]]},"abstract":"<jats:p>\n            Purpose\u2002The aim of this study was to investigate the diagnostic value of cardiac magnetic resonance (CMR)-derived strain parameters in patients with sarcoidosis, and to compare results to standard CMR markers of sarcoidosis (edema\/T2 ratio, early gadolinium enhancement, late gadolinium enhancement) for prediction of disease outcome.<\/jats:p><jats:p>\n            Materials and Methods\u200261 patients with biopsy-proven sarcoidosis underwent CMR examination. According to CMR results, patients were divided into two different groups: patients with (CMR+; n\u200a=\u200a23) and without (CMR\u2013; n\u200a=\u200a38) findings consistent with cardiac sarcoidosis. In addition, a group of healthy age-matched volunteers (controls; n\u200a=\u200a22) served as controls. Left ventricular functional parameters as well as left ventricular longitudinal and circumferential strain were evaluated in all three groups.<\/jats:p><jats:p>\n            Results\u2002Compared to controls, global longitudinal strain (GLS) was significantly impaired in patients with sarcoidosis, irrespective of cardiac involvement. No significant differences in GLS could be revealed between CMR+ and CMR\u2013 patients. Circumferential strain parameters were significantly impaired in CMR+ patients in comparison to CMR\u2013 patients and controls, while no significant differences could be revealed between CMR\u2013 patients and controls. GLS was significantly lower in patients with a negative outcome compared to controls. Compared to the rest of the CMR+ and CMR\u2013 patients, the GLS in patients with a negative outcome was further reduced but did not reach statistical significance.<\/jats:p><jats:p>\n            Conclusion\u2002GLS is the only strain parameter detecting left ventricular functional impairment in sarcoidosis patients with otherwise unsuspicious CMR and controls. GLS is further reduced in patients with a negative outcome. Thus, GLS may have the potential to serve as a marker for early cardiac involvement in sarcoidosis.<\/jats:p><jats:p>\n            Key points\u2002<\/jats:p><jats:p>\n            Citation Format\n          <\/jats:p>","DOI":"10.1055\/a-0598-5099","type":"journal-article","created":{"date-parts":[[2018,7,25]],"date-time":"2018-07-25T18:55:27Z","timestamp":1532544927000},"page":"712-721","source":"Crossref","is-referenced-by-count":20,"title":["Diagnostic Value of Cardiac Magnetic Resonance Strain Analysis for Detection of Cardiac Sarcoidosis"],"prefix":"10.1055","volume":"190","author":[{"given":"Darius","family":"Dabir","sequence":"additional","affiliation":[{"name":"Radiology, University of Bonn, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Meyer","sequence":"additional","affiliation":[{"name":"Radiology, University of Bonn, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Kuetting","sequence":"additional","affiliation":[{"name":"Radiology, University of Bonn, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julian","family":"Luetkens","sequence":"additional","affiliation":[{"name":"Radiology, University of Bonn, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rami","family":"Homsi","sequence":"additional","affiliation":[{"name":"Radiology, University of Bonn, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen","family":"Pizarro","sequence":"additional","affiliation":[{"name":"Medicine II, Cardiology, Pneumology, and Angiology, University of Bonn, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Nadal","sequence":"additional","affiliation":[{"name":"Medical Biometry, University of Bonn, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Thomas","sequence":"additional","affiliation":[{"name":"Radiology, University of Bonn, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2018,7,25]]},"container-title":["R\u00f6Fo - Fortschritte auf dem Gebiet der R\u00f6ntgenstrahlen und der bildgebenden Verfahren"],"original-title":[],"language":"de","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-0598-5099.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,7,26]],"date-time":"2018-07-26T05:28:09Z","timestamp":1532582889000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-0598-5099"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,7,25]]},"references-count":0,"journal-issue":{"issue":"08","published-online":{"date-parts":[[2018,7,25]]},"published-print":{"date-parts":[[2018,8]]}},"URL":"https:\/\/doi.org\/10.1055\/a-0598-5099","relation":{},"ISSN":["1438-9029","1438-9010"],"issn-type":[{"value":"1438-9029","type":"print"},{"value":"1438-9010","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,7,25]]}}}