{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T08:34:00Z","timestamp":1740126840144,"version":"3.37.3"},"reference-count":0,"publisher":"Georg Thieme Verlag KG","issue":"02","funder":[{"DOI":"10.13039\/501100002347","name":"Federal Ministry of Education and Research","doi-asserted-by":"crossref","award":["FKZ 01GI1106"],"award-info":[{"award-number":["FKZ 01GI1106"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Exp Clin Endocrinol Diabetes"],"published-print":{"date-parts":[[2020,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\nBackground Although diabetes is a common complication of acromegaly or Cushing\u00b4s disease, there are only few detailed studies with a focus on cardiovascular risk, metabolic control or diabetes therapy. Here, we provide a comprehensive characterization from the longitudinal DPV (Diabetes Patienten Verlaufsdokumentation) registry.<\/jats:p><jats:p>\nMethods Patients from the registry\u226518 years of age with diabetes and acromegaly or Cushing\u00b4s disease were compared to patients with type 1 diabetes or type 2 diabetes using the statistical software SAS 9.4.<\/jats:p><jats:p>\nResults Patients with diabetes and acromegaly (n=52) or Cushing\u2019s disease (n=15) were significantly younger at diabetes onset (median age 50.1 and 45.0 vs. 59.0 years in type 2 diabetes; both p&lt;0.05). Dyslipidemia was common in both diseases (71.0% and 88.9% vs. 71.8% in type 2 diabetes; n.s.), while hypertension was most frequent in acromegaly (56.8% vs. 20.9% in type 1 diabetes, p&lt;0.00001). 36.5% of patients with acromegaly and 46.7% with Cushing\u00b4s disease receive insulin, compared to 50.4% with type 2 diabetes. Oral antidiabetic drugs were used in 36.5% of patients with acromegaly and 40% with Cushing\u00b4s disease, with a predominance of biguanides and dipeptidyl peptidase-4 inhibitors. HbA1c was well controlled in both groups (median 7.0% and 6.5%; vs. 7.2% in type 2 diabetes).<\/jats:p><jats:p>\nConclusion Patients with acromegaly are at a high risk for cardiovascular disease, reflected by dyslipidemia and hypertension. A high proportion of patients with diabetes in acromegaly or Cushing\u00b4s disease receives insulin. Based on a multicenter register, a sufficient number of patients with rare forms of diabetes can be analyzed.<\/jats:p>","DOI":"10.1055\/a-0600-9649","type":"journal-article","created":{"date-parts":[[2018,10,17]],"date-time":"2018-10-17T18:57:39Z","timestamp":1539802659000},"page":"104-110","source":"Crossref","is-referenced-by-count":3,"title":["Cardivascular Risk Profile in Patients with Diabetes and Acromegaly or Cushing\u2019s Disease \u2013 Analysis from the DPV Database"],"prefix":"10.1055","volume":"128","author":[{"given":"Katharina","family":"Warncke","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Klinikum rechts der Isar, Technische Universit\u00e4t M\u00fcnchen, Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sebastian","family":"Kummer","sequence":"additional","affiliation":[{"name":"Department of General Pediatrics, Neonatology and Pediatric Cardiology, University Children's Hospital, Duesseldorf, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter Herbert","family":"Kann","sequence":"additional","affiliation":[{"name":"Zentrum f\u00fcr Endokrinologie, Diabetologie & Osteologie, Philipps-Universit\u00e4t\/Universit\u00e4tsklinikum Marburg, Marburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dominik","family":"Bergis","sequence":"additional","affiliation":[{"name":"Division of Endocrinology & Diabetes, Department of Internal Medicine 1, University Hospital, Goethe University, Frankfurt am Main, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Esther","family":"Bollow","sequence":"additional","affiliation":[{"name":"Institute of Epidemiology and Medical Biometry, Central Institute for Biomedical Technology, University of Ulm, Ulm, Germany"},{"name":"German Center for Diabetes Research (DZD), M\u00fcnchen-Neuherberg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Hummel","sequence":"additional","affiliation":[{"name":"Specialized Diabetes Practice, Rosenheim"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Flavius","family":"Zoicas","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Diabetes, Department of Medicine 1, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sebastian","family":"Wernert","sequence":"additional","affiliation":[{"name":"AKH Wien, Universit\u00e4tscampus, Wien, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reinhard W.","family":"Holl","sequence":"additional","affiliation":[{"name":"Institute of Epidemiology and Medical Biometry, Central Institute for Biomedical Technology, University of Ulm, Ulm, Germany"},{"name":"German Center for Diabetes Research (DZD), M\u00fcnchen-Neuherberg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2018,10,17]]},"container-title":["Experimental and Clinical Endocrinology &amp; Diabetes"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-0600-9649.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,1,31]],"date-time":"2020-01-31T19:41:27Z","timestamp":1580499687000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-0600-9649"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10,17]]},"references-count":0,"journal-issue":{"issue":"02","published-online":{"date-parts":[[2020,1,31]]},"published-print":{"date-parts":[[2020,2]]}},"URL":"https:\/\/doi.org\/10.1055\/a-0600-9649","relation":{},"ISSN":["0947-7349","1439-3646"],"issn-type":[{"type":"print","value":"0947-7349"},{"type":"electronic","value":"1439-3646"}],"subject":[],"published":{"date-parts":[[2018,10,17]]}}}