{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T03:25:40Z","timestamp":1762917940753},"reference-count":30,"publisher":"Georg Thieme Verlag KG","issue":"08","license":[{"start":{"date-parts":[[2018,8,10]],"date-time":"2018-08-10T00:00:00Z","timestamp":1533859200000},"content-version":"vor","delay-in-days":9,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Endosc Int Open"],"published-print":{"date-parts":[[2018,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Background and study aims\u2002To decrease complications associated with preoperative endoscopic nasobiliary drainage (ENBD) for perihilar cholangiocarcinoma patients, we developed a modified 6-Fr ENBD catheter with multiple side holes (m-ENBD). The aim of this retrospective study was to compare the m-ENBD catheter with a conventional 7-Fr ENBD catheter (c-ENBD). <\/jats:p><jats:p>\n          Patients and methods\u2002This study involved 371 patients with suspected perihilar cholangiocarcinoma who underwent ENBD using a c-ENBD catheter or an m-ENBD catheter. The effectiveness of each catheter and the incidence of complications were evaluated. Univariate and multivariate analyses followed by propensity score matching were performed. <\/jats:p><jats:p>\n          Results\u2002In 145 patients with total bilirubin levels \u2265\u200a2.0\u200amg\/dL prior to drainage, these levels decreased to &lt;\u200a2.0\u200amg\/dL after ENBD in 81.1\u200a% of the c-ENBD patients and in 74.0\u200a% of the m-ENBD patients (P\u200a=\u200a0.325). Post-ENBD cholangitis occurred in 24.9\u200a% of the c-ENBD patients and in 12.4\u200a% of the m-ENBD patients (P\u200a=\u200a0.006). After propensity score matching, the rate of post-ENBD cholangitis (P\u200a=\u200a0.007) and the number of patients requiring subsequent or additional drainage (P\u200a=\u200a0.030) were significantly lower in the m-ENBD group.<\/jats:p><jats:p>\n          Conclusion\u2002The modified 6-Fr ENBD catheter was associated with a lower incidence of post-ENBD cholangitis than the conventional 7-Fr ENBD catheter, and the incidence of subsequent or additional drainage procedures was also decreased. <\/jats:p>","DOI":"10.1055\/a-0614-2202","type":"journal-article","created":{"date-parts":[[2020,8,4]],"date-time":"2020-08-04T11:39:38Z","timestamp":1596541178000},"page":"E1020-E1030","source":"Crossref","is-referenced-by-count":8,"title":["Effectiveness of a modified 6-Fr endoscopic nasobiliary drainage catheter for patients with preoperative perihilar cholangiocarcinoma"],"prefix":"10.1055","volume":"06","clinical-trial-number":[{"clinical-trial-number":"umin000025631","registry":"10.18810\/umin-japan"}],"author":[{"given":"Hiroki","family":"Kawashima","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Nagoya University Graduate School of Medicine, Nagoya, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshiki","family":"Hirooka","sequence":"additional","affiliation":[{"name":"Department of Endoscopy, Nagoya University Hospital, Nagoya, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eizaburo","family":"Ohno","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Nagoya University Graduate School of Medicine, Nagoya, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takuya","family":"Ishikawa","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Nagoya University Graduate School of Medicine, Nagoya, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryoji","family":"Miyahara","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Nagoya University Graduate School of Medicine, Nagoya, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Osamu","family":"Watanabe","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Nagoya University Graduate School of Medicine, Nagoya, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuhiko","family":"Hayashi","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Nagoya University Graduate School of Medicine, Nagoya, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masatoshi","family":"Ishigami","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Nagoya University Graduate School of Medicine, Nagoya, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Senju","family":"Hashimoto","sequence":"additional","affiliation":[{"name":"Department of Liver, Biliary Tract and Pancreas Diseases, Fujita Health University Hospital, Toyoake, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomoki","family":"Ebata","sequence":"additional","affiliation":[{"name":"Division of Surgical Oncology, Department of Surgery, Nagoya University Graduate School of Medicine, Nagoya, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masato","family":"Nagino","sequence":"additional","affiliation":[{"name":"Division of Surgical Oncology, Department of Surgery, Nagoya University Graduate School of Medicine, Nagoya, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hidemi","family":"Goto","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Nagoya University Graduate School of Medicine, Nagoya, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2018,8,10]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1007\/BF02350901","article-title":"Preoperative management of hilar cholangiocarcinoma","volume":"2","author":"M Nagino","year":"1995","journal-title":"J Hepatobiliary Pancreat Surg"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1007\/s005340050170","article-title":"Aggressive preoperative management and extended surgery for hila cholangiocarcinoma: Nagoya experience","volume":"7","author":"Y Nimura","year":"2000","journal-title":"J Hepatobiliary Pancreat Surg"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1007\/s00534-007-1277-7","article-title":"Preoperative biliary drainage for biliary tract and ampullary carcinomas","volume":"15","author":"M 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