{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T10:50:40Z","timestamp":1792320640062,"version":"4.4.0"},"reference-count":23,"publisher":"Georg Thieme Verlag KG","issue":"08","license":[{"start":{"date-parts":[[2018,8,10]],"date-time":"2018-08-10T00:00:00Z","timestamp":1533859200000},"content-version":"vor","delay-in-days":9,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Endosc Int Open"],"published-print":{"date-parts":[[2018,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Background and study aims\u2002The efficacy of per oral endoscopic myotomy (POEM) in non-achalasia esophageal motility disorders such as esophagogastric junction outflow obstruction (EGJOO), diffuse esophageal spasm (DES), and jackhammer esophagus (JE) has not been well demonstrated. The aim of this international multicenter study was to assess clinical outcomes of POEM in patients with non-achalasia disorders, namely DES, JE, and EGJOO, in a large cohort of patients.<\/jats:p><jats:p>\n          Patients and methods\u2002This was a retrospective study at 11 centers. Consecutive patients who underwent POEM for EGJOO, DES, or JE between 1\/2014 and 9\/2016 were included. Rates of technical success (completion of myotomy), clinical response (symptom improvement\/Eckardt score\u200a\u2264\u200a3), and adverse events (AEs, severity per ASGE lexicon) were ascertained. \n        <\/jats:p><jats:p>\n          Results\u2002Fifty patients (56\u200a% female; mean age 61.7 years) underwent POEM for EGJOO (n\u200a=\u200a15), DES (n\u200a=\u200a17), and JE (n\u200a=\u200a18). The majority of patients (68\u200a%) were treatment-na\u00efve. Technical success was achieved in all patients with a mean procedural time of 88.4\u200a\u00b1\u200a44.7\u200amin. Mean total myotomy length was 15.1\u200a\u00b1\u200a4.7\u200acm. Chest pain improved in 88.9\u200a% of EGJOO and 87.0\u200a% of DES\/JE (P\u200a=\u200a0.88). Clinical success was achieved in 93.3\u200a% of EGJOO and in 84.9\u200a% of DES\/JE (P\u200a=\u200a0.41) with a median follow-up of 195 and 272 days, respectively. Mean Eckardt score decreased from 6.2 to 1.0 in EGJOO (P\u200a&lt;\u200a0.001) and from 6.9 to 1.9 in DES\/JE (P\u200a&lt;\u200a0.001). A total of 9 (18\u200a%) AEs occurred and were rated as mild in 55.6\u200a% and moderate in 44.4\u200a%.<\/jats:p><jats:p>\n          Conclusion\u2002POEM is effective and safe in management of non-achalasia esophageal motility disorders, which include DES, JE, and EGJOO.<\/jats:p>","DOI":"10.1055\/a-0625-6288","type":"journal-article","created":{"date-parts":[[2018,12,11]],"date-time":"2018-12-11T09:53:50Z","timestamp":1544522030000},"page":"E1031-E1036","source":"Crossref","is-referenced-by-count":95,"title":["Peroral endoscopic myotomy is effective and safe in non-achalasia esophageal motility disorders: an international multicenter study"],"prefix":"10.1055","volume":"06","author":[{"given":"Mouen A.","family":"Khashab","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Johns Hopkins Medical Institutions, Baltimore, Maryland, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pietro","family":"Familiari","sequence":"additional","affiliation":[{"name":"Digestive Endoscopy Unit, Universit\u00e0 Cattolica del Sacro Cuore, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter V.","family":"Draganov","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Hepatology and Nutrition, University of Florida, Gainesville, Florida, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanaa Dakour","family":"Aridi","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Johns Hopkins Medical Institutions, Baltimore, Maryland, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joo Young","family":"Cho","sequence":"additional","affiliation":[{"name":"Digestive Disease Center, CHA Budang Medical Center, CHA University, Seongnam, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Ujiki","sequence":"additional","affiliation":[{"name":"Department of Surgery, Section of Minimally Invasive Surgery, NorthShore University Health System, Evanston, Illinois, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo","family":"Rio Tinto","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Hepatopancreatology and Digestive Oncology, Erasme University Hospital, Universit\u00e9 Libre de Bruxelles"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hubert","family":"Louis","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Hepatopancreatology and Digestive Oncology, Erasme University Hospital, Universit\u00e9 Libre de Bruxelles"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pankaj N.","family":"Desai","sequence":"additional","affiliation":[{"name":"Surat Institute of Digestive Sciences, Surat, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vic","family":"Velanovich","sequence":"additional","affiliation":[{"name":"Division of General Surgery, University of South Florida Morsani College of Medicine, Tampa, Florida, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo","family":"Alb\u00e9niz","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Complejo Hospitalario de Navarra, Pamplona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amyn","family":"Haji","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Kings College Hospital NHS Foundation Trust, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey","family":"Marks","sequence":"additional","affiliation":[{"name":"Department of Surgery, University Hospitals Cleveland Medical Center, Cleveland, Ohio, United 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