{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T05:21:57Z","timestamp":1778649717686,"version":"3.51.4"},"reference-count":0,"publisher":"Georg Thieme Verlag KG","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Drug Res (Stuttg)"],"published-print":{"date-parts":[[2018,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\nBackground  Cisplatin is an anti-cancer drug that causes nephrotoxicity and oxidative stress. Extracts of Nigella sativa is nephroprotective. Vitamin E is also a potent antioxidant. This study sought to determine a possible synergistic effect of administering the two agents prior to cisplatin use on nephrotoxicity and oxidative stress.<\/jats:p><jats:p>\nMethods  48 male Wistar rats were randomly divided into 6 groups of 8 rats each. Group I served as the control. Group II received cisplatin without any treatment for 6 days. Groups III, IV, V and VI received 100\u2009mg\/kg Nigella sativa (NS), 200\u2009mg\/kg NS, 100\u2009mg\/kg Vitamin E and 200\u2009mg\/kg NS+100\u2009mg\/kg Vitamin E respectively for 5 days prior to 6 days administration of cisplatin. On the last day of the experiment, all the animals were sacrificed and serum samples collected for analysis.<\/jats:p><jats:p>\nResults  Cisplatin administration caused a significant increase in creatinine level (p&lt;0.01), urea level (p&lt;0.01), sodium concentration and malondialdehyde level (p&lt;0.001). Pre-administration with NS caused a significant reduction in creatinine level (p&lt;0.001), urea level (p&lt;0.001), sodium concentration (p&lt;0.001) and malondialdehyde (p&lt;0.01) level. Pre-administration with vitamin E caused a significant reduction in creatinine level (p&lt;0.001), urea level (p&lt;0.01), sodium concentration (p&lt;0.001) and malondialdehyde level. They both also caused a significant increase in superoxide dismutase, reduced glutathione and catalase (CAT) levels. The combination of NS and vitamin E however did not show significant synergistic effects.<\/jats:p><jats:p>\nConclusion  These results suggest that even though pre-administration of the two agents protect against renal toxicity and oxidative stress, the effects are however not collaborative.<\/jats:p>","DOI":"10.1055\/a-0626-7003","type":"journal-article","created":{"date-parts":[[2018,6,26]],"date-time":"2018-06-26T19:38:32Z","timestamp":1530041912000},"page":"696-703","source":"Crossref","is-referenced-by-count":13,"title":["Protective but Non-Synergistic Effects of Nigella Sativa and Vitamin E against Cisplatin-Induced Renal Toxicity and Oxidative Stress in Wistar Rats"],"prefix":"10.1055","volume":"68","author":[{"given":"Abdulwasiu","family":"Busari","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Therapeutics and Toxicology , Lagos, Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdullahi","family":"Adejare","sequence":"additional","affiliation":[{"name":"Department of Physiology, College of Medicine of the University of Lagos, Lagos, Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abiodun","family":"Shodipe","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Therapeutics and Toxicology , Lagos, Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oludaisi","family":"Oduniyi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Khadijah","family":"Ismail-Badmus","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ibrahim","family":"Oreagba","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Therapeutics and Toxicology , Lagos, Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2018,6,26]]},"container-title":["Drug Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-0626-7003.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,11,20]],"date-time":"2018-11-20T18:43:09Z","timestamp":1542739389000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-0626-7003"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,6,26]]},"references-count":0,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2018,11,20]]},"published-print":{"date-parts":[[2018,12]]}},"URL":"https:\/\/doi.org\/10.1055\/a-0626-7003","relation":{},"ISSN":["2194-9379","2194-9387"],"issn-type":[{"value":"2194-9379","type":"print"},{"value":"2194-9387","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,6,26]]}}}