{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T07:52:11Z","timestamp":1759564331010},"reference-count":0,"publisher":"Georg Thieme Verlag KG","issue":"06","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ultraschall in Med"],"published-print":{"date-parts":[[2018,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Objectives\u2002We sought to assess the causes and outcomes of severe VM diagnosed de novo after 24 weeks of gestation where a mid-trimester anomaly scan was described as normal.<\/jats:p><jats:p>\n          Methods\u2002Multicenter retrospective study of five European fetal medicine centers. The inclusion criteria were normal anatomy at the mid-trimester scan, uni\/bilateral finding of posterior ventricle measuring \u2265\u200a15\u200amm after 24 weeks with neonatal and postnatal pediatric and\/or neurological assessment data.<\/jats:p><jats:p>\n          Results\u2002Of 74 potentially eligible cases, 10 underwent termination, the outcome was missing in 19 cases and there was 1 neonatal death. Therefore, 44 formed the study cohort with a median gestation at diagnosis of 32\u200a+\u200a0 weeks (25\u200a+\u200a6\u200a\u2013\u200a40\u200a+\u200a5). VM was unilateral in five cases. Agenesis of the corpus callosum (ACC) and grade III\/IV intraventricular hemorrhage (IVH) accounted for 14 cases each. ACC was isolated in 9 fetuses. Obstructive abnormalities included 5 arachnoid and 1 cavum velum interpositum cyst. Four fetuses had an associated suspected or confirmed genetic condition, 2 congenital infections, 1 abnormal cortical development and the etiology was unknown in 3\/44. Postnatal assessment at median 20 months (3\u200a\u2013\u200a96) showed 22\/44 (50\u200a%) normal, 7 (16\u200a%) mildly abnormal and 15 (34\u200a%) severely abnormal neurodevelopmental outcomes.<\/jats:p><jats:p>\n          Conclusion\u2002One half of babies with severe VM diagnosed after 24 weeks have normal infant outcome with ACC and IVH representing the most common causes. Etiology is the most important factor affecting the prognosis of fetuses with severe VM diagnosed at late gestation.<\/jats:p>","DOI":"10.1055\/a-0627-7173","type":"journal-article","created":{"date-parts":[[2018,7,5]],"date-time":"2018-07-05T23:05:53Z","timestamp":1530831953000},"page":"675-689","source":"Crossref","is-referenced-by-count":5,"title":["Etiology and Prognosis of Severe Ventriculomegaly Diagnosed at\u00a0Late Gestation"],"prefix":"10.1055","volume":"39","author":[{"given":"Andrea","family":"Dall\u2019Asta","sequence":"additional","affiliation":[{"name":"Centre for Fetal Care, Queen Charlotte\u2019s and Chelsea Hospital, Imperial College Healthcare NHS Trust, London, United Kingdom"},{"name":"Obstetrics and Gynaecology Unit, University of Parma, Parma, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noortje","family":"van Oostrum","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Gynaecology and Prenatal Diagnosis, Erasmus Medical Centre, Rotterdam, the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sheikh","family":"Basheer","sequence":"additional","affiliation":[{"name":"Centre for Fetal Care, Queen Charlotte\u2019s and Chelsea Hospital, Imperial College Healthcare NHS Trust, London, United Kingdom"},{"name":"Department of Paediatrics and Neonatal Medicine, Hammersmith Hospital, Imperial College Healthcare NHS Trust, London, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gowrishankar","family":"Paramasivam","sequence":"additional","affiliation":[{"name":"Centre for Fetal Care, Queen Charlotte\u2019s and Chelsea Hospital, Imperial College Healthcare NHS Trust, London, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tullio","family":"Ghi","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynaecology Unit, University of Parma, Parma, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Letizia","family":"Galli","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynaecology Unit, University of Parma, Parma, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irene","family":"Groenenberg","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Gynaecology and Prenatal Diagnosis, Erasmus Medical Centre, Rotterdam, the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amanda","family":"Tangi","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, University of Brescia, Brescia, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrizia","family":"Accorsi","sequence":"additional","affiliation":[{"name":"Department of Child Neurology and Psychiatry, ASST Spedali Civili, Brescia, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monica","family":"Echevarria","sequence":"additional","affiliation":[{"name":"Fetal Medicine Section, Department of Obstetrics, Gynecology and Reproductive Medicine, University Hospital Quiron Dexeus, Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Angeles Rodr\u00edguez Perez","sequence":"additional","affiliation":[{"name":"Fetal Medicine Section, Department of Obstetrics, Gynecology and Reproductive Medicine, University Hospital Quiron Dexeus, Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerard","family":"Albaiges Baiget","sequence":"additional","affiliation":[{"name":"Fetal Medicine Section, Department of Obstetrics, Gynecology and Reproductive Medicine, University Hospital Quiron Dexeus, Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Federico","family":"Prefumo","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, University of Brescia, Brescia, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tiziana","family":"Frusca","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynaecology Unit, University of Parma, Parma, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Attie","family":"Go","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Gynaecology and Prenatal Diagnosis, Erasmus Medical Centre, Rotterdam, the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christoph","family":"Lees","sequence":"additional","affiliation":[{"name":"Centre for Fetal Care, Queen Charlotte\u2019s and Chelsea Hospital, Imperial College Healthcare NHS Trust, London, United Kingdom"},{"name":"Department of Surgery and Cancer, Imperial College London, United Kingdom"},{"name":"Department of Development and Regeneration, KU\u00a0Leuven, Leuven, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2018,7,5]]},"container-title":["Ultraschall in der Medizin - European Journal of Ultrasound"],"original-title":[],"language":"de","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-0627-7173.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,12,14]],"date-time":"2018-12-14T23:31:43Z","timestamp":1544830303000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-0627-7173"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,7,5]]},"references-count":0,"journal-issue":{"issue":"06","published-online":{"date-parts":[[2018,12,14]]},"published-print":{"date-parts":[[2018,12]]}},"URL":"https:\/\/doi.org\/10.1055\/a-0627-7173","relation":{},"ISSN":["0172-4614","1438-8782"],"issn-type":[{"value":"0172-4614","type":"print"},{"value":"1438-8782","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,7,5]]}}}