{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T20:28:50Z","timestamp":1774988930133,"version":"3.50.1"},"reference-count":11,"publisher":"Georg Thieme Verlag KG","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Endoscopy"],"published-print":{"date-parts":[[2018,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Background\u2002Volumetric laser endomicroscopy (VLE) provides circumferential images 3\u200amm into the biliary and pancreatic ducts. We aimed to correlate VLE images with the normal and abnormal microstructure of these ducts.<\/jats:p><jats:p>\n          Methods: Samples from patients undergoing hepatic or pancreatic resection were evaluated. VLE images were collected using a low-profile VLE catheter inserted manually into the biliary and pancreatic ducts ex vivo. Histological correlation was assessed by two unblinded investigators.<\/jats:p><jats:p>\n          Results\u200225 patients (20 liver and 5 pancreatic samples) and 111 images were analyzed. VLE revealed three histological layers: epithelium, connective tissue, and parenchyma. It identified distinctive patterns for primary sclerosing cholangitis (PSC), pancreatic cysts, neuroendocrine tumor, and adenocarcinoma adjacent to the pancreatic duct or ampulla. VLE failed to identify dysplasia in a dominant stricture and inflammatory infiltrates in PSC. Reflectivity measurements of the liver parenchyma diagnosed liver cirrhosis with high sensitivity.<\/jats:p><jats:p>\n          Conclusions\u2002VLE can identify histological changes in the biliary and pancreatic ducts allowing real-time diagnosis. Further studies are needed to measure the accuracy of VLE in a larger sample and to validate our findings in vivo.<\/jats:p>","DOI":"10.1055\/a-0631-1634","type":"journal-article","created":{"date-parts":[[2018,6,18]],"date-time":"2018-06-18T23:09:16Z","timestamp":1529363356000},"page":"1089-1094","source":"Crossref","is-referenced-by-count":11,"title":["Volumetric laser endomicroscopy in the biliary and pancreatic ducts: a feasibility study with histological correlation"],"prefix":"10.1055","volume":"50","author":[{"given":"Juan E.","family":"Corral","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Mayo Clinic, Jacksonville, Florida, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Omar Y.","family":"Mousa","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Mayo Clinic, Jacksonville, Florida, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Murli","family":"Krishna","sequence":"additional","affiliation":[{"name":"Division of Pathology, Mayo Clinic, Jacksonville, Florida, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iris J. M.","family":"Levink","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Erasmus University Medical Center, Rotterdam, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Khela R.","family":"Pursell","sequence":"additional","affiliation":[{"name":"Division of Pathology, Mayo Clinic, Jacksonville, Florida, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammad","family":"Afsh","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Mayo Clinic, Jacksonville, Florida, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul T.","family":"Kr\u00f6ner","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Mayo Clinic, Jacksonville, Florida, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Denise M.","family":"Harnois","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Mayo Clinic, Jacksonville, Florida, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Herbert C.","family":"Wolfsen","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Mayo Clinic, Jacksonville, Florida, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael B.","family":"Wallace","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Mayo Clinic, Jacksonville, Florida, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frank J.","family":"Lukens","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Mayo Clinic, Jacksonville, Florida, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2018,6,18]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1016\/j.giec.2009.06.006","article-title":"Optical coherence tomography for bile and pancreatic duct imaging","volume":"19","author":"P A Testoni","year":"2009","journal-title":"Gastrointest Endosc Clin N Am"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1016\/j.dld.2006.05.019","article-title":"Optical coherence tomography compared with histology of the main pancreatic duct structure in normal and pathological conditions: an \u201cex vivo study\u201d","volume":"38","author":"P A Testoni","year":"2006","journal-title":"Dig Liver Dis"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1111\/j.1572-0241.2006.00940.x","article-title":"Intraductal optical coherence tomography for investigating main pancreatic duct 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coherance tomography (OCT) for indeterminate biliary strictures: initial report on in-vivo evaluation during ERCP","volume":"85","author":"V Joshi","year":"2017","journal-title":"Gastrointest Endosc"},{"key":"ref10","first-page":"360","article-title":"Understanding interobserver agreement: the kappa statistic","volume":"37","author":"A J Viera","year":"2005","journal-title":"Fam Med"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1016\/j.gie.2005.06.054","article-title":"In vivo optical coherence tomography imaging of the pancreatic and biliary ductal system","volume":"62","author":"P Singh","year":"2005","journal-title":"Gastrointest Endosc"}],"container-title":["Endoscopy"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-0631-1634.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,5,17]],"date-time":"2021-05-17T09:11:56Z","timestamp":1621242716000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-0631-1634"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,6,18]]},"references-count":11,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2018,11,6]]},"published-print":{"date-parts":[[2018,11]]}},"URL":"https:\/\/doi.org\/10.1055\/a-0631-1634","relation":{},"ISSN":["0013-726X","1438-8812"],"issn-type":[{"value":"0013-726X","type":"print"},{"value":"1438-8812","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,6,18]]}}}