{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T23:42:56Z","timestamp":1784590976370,"version":"3.55.0"},"reference-count":0,"publisher":"Georg Thieme Verlag KG","issue":"07","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Horm Metab Res"],"published-print":{"date-parts":[[2018,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We studied demographic, metabolic, and clinical characteristics of patients with diabetes and autoimmune hepatitis (AIH) from the German\/Austrian DPV registry. A total of 139 patients with diabetes and AIH were analyzed and compared to 437 728 patients with diabetes without AIH. The prevalence of AIH in patients with T1DM (44.8\/100 000) seems higher than in the general population, the prevalence of AIH in patients with T2DM (23.6\/100 000) does not seem to be increased. Patients with T2DM and AIH had a shorter duration of diabetes (p=0.007) and a higher proportion of females (p&lt;0.001) compared to T2DM without AIH. Patients with diabetes (T1DM or T2DM) and AIH required higher insulin doses (p&lt;0.001 and p=0.03, respectively) and showed increased liver enzymes (aspartate transaminase, alanine transaminase, gamma-glutamyltransferase) compared to diabetes patients without (all p&lt;0.001). We detected a lower percentage of patients treated with oral antidiabetic drugs (p=0.01) and a higher percentage of patients treated by insulin in patients with T2DM and AIH (p&lt;0.001) compared to patients with T2DM alone. We observed a higher incidence of autoimmune thyroid disease (AIT) in patients with diabetes (T1DM or T2DM) and AIH (p&lt;0.001) compared to diabetes patients without AIH. AIH seems more frequent in patients with T1DM. Patients with diabetes and AIH require intensification of antidiabetic therapy and seem to have a higher prevalence of AIT.<\/jats:p>","DOI":"10.1055\/a-0631-2468","type":"journal-article","created":{"date-parts":[[2018,7,10]],"date-time":"2018-07-10T18:42:01Z","timestamp":1531248121000},"page":"568-574","source":"Crossref","is-referenced-by-count":7,"title":["Diabetes Mellitus and Autoimmune Hepatitis: Demographical and Clinical Description of a Relatively Rare Phenotype"],"prefix":"10.1055","volume":"50","author":[{"given":"Gideon","family":"de Sousa","sequence":"additional","affiliation":[{"name":"Children\u2019s Hospital Dortmund, Dortmund, Germany"},{"name":"Department of Pediatrics, University of Witten\/Herdecke, Witten, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole","family":"Prinz","sequence":"additional","affiliation":[{"name":"Institute of Epidemiology and Medical Biometry, Central Institute for Biomedical Technology, University of Ulm, Ulm, Germany"},{"name":"German Center for Diabetes Research (DZD), Munich-Neuherberg, Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marianne","family":"Becker","sequence":"additional","affiliation":[{"name":"Children\u2019s Hospital, Helios Dr. Horst Schmidt Kliniken Wiesbaden, Wiesbaden, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renate","family":"D\u00fcrr","sequence":"additional","affiliation":[{"name":"Children\u2019s Hospital Rems-Murr, Winnenden, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uta","family":"Faller","sequence":"additional","affiliation":[{"name":"Children\u2019s Hospital, Oberschwabenklinik, Ravensburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dagmar","family":"Meraner","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Adolescent Medicine, University Innsbruck, Innsbruck, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolai","family":"Heise","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Helfenstein Klinik, Geislingen\/Steige, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Illa","family":"Engelmann","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Medius Kliniken, N\u00fcrtingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Herbert","family":"Bruckmayer","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Hospital Ruhpolding, Ruhpolding, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dagobert","family":"Wiemann","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Magdeburg, Magdeburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Fritsch","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Adolescent Medicine, Medical University Vienna, Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernd","family":"Stratmann","sequence":"additional","affiliation":[{"name":"Diabeteszentrum, Herz- und Diabeteszentrum NRW, Ruhr-Universit\u00e4t Bochum, Bad Oeynhausen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reinhard","family":"Holl","sequence":"additional","affiliation":[{"name":"Institute of Epidemiology and Medical Biometry, Central Institute for Biomedical Technology, University of Ulm, Ulm, Germany"},{"name":"German Center for Diabetes Research (DZD), Munich-Neuherberg, Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2018,7,10]]},"container-title":["Hormone and Metabolic Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-0631-2468.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,7,10]],"date-time":"2018-07-10T18:42:07Z","timestamp":1531248127000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-0631-2468"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,7]]},"references-count":0,"journal-issue":{"issue":"07","published-online":{"date-parts":[[2018,7,10]]},"published-print":{"date-parts":[[2018,7]]}},"URL":"https:\/\/doi.org\/10.1055\/a-0631-2468","relation":{},"ISSN":["0018-5043","1439-4286"],"issn-type":[{"value":"0018-5043","type":"print"},{"value":"1439-4286","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,7]]}}}