{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T14:53:17Z","timestamp":1787928797692,"version":"build-2784847793"},"reference-count":0,"publisher":"Georg Thieme Verlag KG","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J Sports Med"],"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The development of new strategies to attenuate exercise-induced muscle damage may be helpful for training regimens. The aim of this study was to determine whether a oral formulation of angiotensin Ang-(1-7)[HP\u03b2CD\/Ang-(1-7)] is effective to reduce pain, and muscle damage markers after eccentric-overload exercise. HP\u03b2CD (Placebo) and HP\u03b2CD\/Ang-(1-7) (Ang-(1-7) group were treated for 7 days (one capsule\/day). The pain was measured by visual analogue scale, maximal strength (MS) using force platform. Blood samples were collected for cytokines and creatine kinase (CK) analysis. The Ang-(1-7)-treated group reported less pain immediately (3.46\u00b10.64 vs. placebo 3.80\u00b10.77\u2009cm) and 24\u2009h after exercise (3.07\u00b10.71 vs. 3.73\u00b10.58\u2009cm placebo) and higher MS at 24\u2009h (24\u00b112\u2009N) and 48\u2009h (30\u00b115\u2009N) vs. placebo (-8\u00b19\u2009N and -10\u00b19\u2009N). The CK for Ang-(1-7) (0.5\u00b10.1 and 0.9\u00b10.2 U\/L) were lower at 48 and 72\u2009h vs. placebo (fold changes of 1.7\u00b10.5 and 1.5\u00b10.3 U\/L). The TNF-\u03b1 level was lower in the treated group post-exercise (38\u00b12.5\u2009pg\/ml) vs. placebo (45\u00b12.9\u2009pg\/ml) but no significant changes were observed for IL-6 and IL-10. Our data indicate that treatment with Ang-(1-7) may attenuate pain, some of the muscle damage markers and improves performance following eccentric exercise.<\/jats:p>","DOI":"10.1055\/a-0633-8892","type":"journal-article","created":{"date-parts":[[2018,6,25]],"date-time":"2018-06-25T19:34:20Z","timestamp":1529955260000},"page":"743-748","source":"Crossref","is-referenced-by-count":26,"title":["Eccentric Overload Muscle Damage is Attenuated By a Novel Angiotensin- (1-7) Treatment"],"prefix":"10.1055","volume":"39","author":[{"given":"Lenice","family":"Becker","sequence":"additional","affiliation":[{"name":"Sports Department, School of Physical Education, Physiotherapy, and Occupational Therapy (EEFFTO), Federal University of Minas Gerais, Brazil"},{"name":"National Institute of Science and Technology in Nanobiopharmaceutics, Department of Physiology and Biophysics, Institute of Biological Sciences, Federal University of Minas Gerais, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N\u00e1dia","family":"Totou","sequence":"additional","affiliation":[{"name":"Sport Center, Federal University of Ouro Preto, Ouro Preto, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samara","family":"Moura","sequence":"additional","affiliation":[{"name":"Sport Center, Federal University of Ouro Preto, Ouro Preto, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucas","family":"Kangussu","sequence":"additional","affiliation":[{"name":"Sports Department, School of Physical Education, Physiotherapy, and Occupational Therapy (EEFFTO), Federal University of Minas Gerais, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruben","family":"Mill\u00e1n","sequence":"additional","affiliation":[{"name":"National Institute of Science and Technology in Nanobiopharmaceutics, Department of Physiology and Biophysics, Institute of Biological Sciences, Federal University of Minas Gerais, Brazil"},{"name":"Department of Chemistry, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Campagnole-Santos","sequence":"additional","affiliation":[{"name":"National Institute of Science and Technology in Nanobiopharmaceutics, Department of Physiology and Biophysics, Institute of Biological Sciences, Federal University of Minas Gerais, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Coelho","sequence":"additional","affiliation":[{"name":"Sport Center, Federal University of Ouro Preto, Ouro Preto, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daisy","family":"Motta-Santos","sequence":"additional","affiliation":[{"name":"National Institute of Science and Technology in Nanobiopharmaceutics, Department of Physiology and Biophysics, Institute of Biological Sciences, Federal University of Minas Gerais, Brazil"},{"name":"Sports Department, School of Physical Education, Physiotherapy, and Occupational Therapy (EEFFTO), Federal University of Minas Gerais, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robson","family":"Santos","sequence":"additional","affiliation":[{"name":"National Institute of Science and Technology in Nanobiopharmaceutics, Department of Physiology and Biophysics, Institute of Biological Sciences, Federal University of Minas Gerais, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2018,6,25]]},"container-title":["International Journal of Sports Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-0633-8892.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,8,27]],"date-time":"2018-08-27T19:11:46Z","timestamp":1535397106000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-0633-8892"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,6,25]]},"references-count":0,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2018,8,27]]},"published-print":{"date-parts":[[2018,10]]}},"URL":"https:\/\/doi.org\/10.1055\/a-0633-8892","relation":{},"ISSN":["0172-4622","1439-3964"],"issn-type":[{"value":"0172-4622","type":"print"},{"value":"1439-3964","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,6,25]]}}}