{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T17:49:34Z","timestamp":1769881774168,"version":"3.49.0"},"reference-count":0,"publisher":"Georg Thieme Verlag KG","issue":"09","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Horm Metab Res"],"published-print":{"date-parts":[[2018,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Craniopharyngioma is a sellar\/suprasellar benign tumor whose aggressiveness may imply in endocrine disturbances (hypothalamic obesity and hormone deficiencies). Fifty-seven patients were evaluated according to clinical characteristics, hypothalamic involvement, type of treatment, anthropometric variables, adiposity indexes (body mass index Z score category at diagnosis and post-treatment, total body fat, visceral adipose tissue, and metabolic syndrome components) and analyzed through multiple regression and logistic models. Patients were stratified according to growth hormone deficiency and recombinant human growth hormone use. Mean ages at diagnosis and at study evaluation were 9.6 and 16.6 years old, respectively. A set of 43\/57 (75.4%) patients presented with important hypothalamic involvement, 24\/57 (42.1%) received surgical treatment and cranial radiotherapy, and 8\/57 (14%) interferon-\u03b1 exclusively. Fifty-five patients (96.5%) were considered growth hormone deficient, and 26\/57 (45.6%) grew despite no recombinant human growth hormone replacement therapy. At diagnosis, 12\/57 (21%) patients were obese, and 33\/57 (57.9%) at study evaluation, and after 3.2 years (median) post first therapy. There was no influence of height Z score on body mass index Z score. Body mass index Z score at diagnosis positively influenced body mass index Z score, total body fat, waist circumference and the presence of the metabolic syndrome post-treatment. Replacement of recombinant human growth hormone decreased total body fat and visceral adipose tissue. Craniopharyngioma patients worsened body mass index Z score category 3.2 years (median) after first treatment. Body mass index Z score increased due to real weight gain, without height decrease. Replacement of recombinant human growth hormone had beneficial effect on adiposity.<\/jats:p>","DOI":"10.1055\/a-0641-5956","type":"journal-article","created":{"date-parts":[[2018,6,30]],"date-time":"2018-06-30T05:28:22Z","timestamp":1530336502000},"page":"675-682","source":"Crossref","is-referenced-by-count":20,"title":["Childhood Craniopharyngioma: A 22-Year Challenging Follow-Up in a Single Center"],"prefix":"10.1055","volume":"50","author":[{"given":"Patr\u00edcia","family":"Tosta-Hernandez","sequence":"first","affiliation":[{"name":"Pediatric Endocrinology Division, Federal University of S\u00e3o Paulo \u2013 UNIFESP\/EPM, S\u00e3o Paulo, Brazil"},{"name":"Pediatric Oncology Institute, Federal University of S\u00e3o Paulo \u2013 IOP\/GRAACC \u2013 UNIFESP\/EPM, S\u00e3o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adriana","family":"Siviero-Miachon","sequence":"first","affiliation":[{"name":"Pediatric Endocrinology Division, Federal University of S\u00e3o Paulo \u2013 UNIFESP\/EPM, S\u00e3o Paulo, Brazil"},{"name":"Pediatric Oncology Institute, Federal University of S\u00e3o Paulo \u2013 IOP\/GRAACC \u2013 UNIFESP\/EPM, S\u00e3o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nasjla","family":"da Silva","sequence":"additional","affiliation":[{"name":"Pediatric Oncology Institute, Federal University of S\u00e3o Paulo \u2013 IOP\/GRAACC \u2013 UNIFESP\/EPM, S\u00e3o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Cappellano","sequence":"additional","affiliation":[{"name":"Pediatric Oncology Institute, Federal University of S\u00e3o Paulo \u2013 IOP\/GRAACC \u2013 UNIFESP\/EPM, S\u00e3o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcelo","family":"Pinheiro","sequence":"additional","affiliation":[{"name":"Rheumatology Division, Federal University of S\u00e3o Paulo \u2013 UNIFESP\/EPM, S\u00e3o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angela","family":"Spinola-Castro","sequence":"additional","affiliation":[{"name":"Pediatric Endocrinology Division, Federal University of S\u00e3o Paulo \u2013 UNIFESP\/EPM, S\u00e3o Paulo, Brazil"},{"name":"Pediatric Oncology Institute, Federal University of S\u00e3o Paulo \u2013 IOP\/GRAACC \u2013 UNIFESP\/EPM, S\u00e3o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2018,6,29]]},"container-title":["Hormone and Metabolic Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-0641-5956.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,9,5]],"date-time":"2018-09-05T22:55:10Z","timestamp":1536188110000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-0641-5956"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,6,29]]},"references-count":0,"journal-issue":{"issue":"09","published-online":{"date-parts":[[2018,9,5]]},"published-print":{"date-parts":[[2018,9]]}},"URL":"https:\/\/doi.org\/10.1055\/a-0641-5956","relation":{},"ISSN":["0018-5043","1439-4286"],"issn-type":[{"value":"0018-5043","type":"print"},{"value":"1439-4286","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,6,29]]}}}