{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T13:51:14Z","timestamp":1762005074551},"reference-count":0,"publisher":"Georg Thieme Verlag KG","issue":"01","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Endoscopy"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Background\u2002Esophagogastroduodenoscopy (EGD) is the standard method for diagnosis of esophageal and gastric varices in children. In this prospective study we evaluated the use of PillCam esophageal capsule endoscopy (ECE) in pediatric patients. <\/jats:p><jats:p>\n          Methods\u2002Patients aged 7 to 18 years presenting with portal hypertension and\/or cirrhosis underwent ECE (PillCam ESO 2, Given Imaging Ltd.) followed by EGD. <\/jats:p><jats:p>\n          Results\u2002102 patients were screened, 81 (52 boys; mean age 13.96\u200a\u00b1\u200a0.25 years) were included and 21 were excluded (16 for \u201ccandy test\u201d failure). Esophageal varices were identified by EGD in 62 patients (77\u200a%) and by ECE in 57 patients (70\u200a%) using the de Franchis classification (DFC). The sensitivity of ECE for esophageal varices was 92\u200a% and the specificity was 100\u200a% using DFC. Based upon 57\/81 patients with small, medium, and large varices on both ECE and EGD, using DFC, the sensitivity, specificity, positive (PPV) and negative predictive value (NPV) were 55\u200a%, 92\u200a%, 89\u200a%, and 63\u200a%, respectively, giving a total overall accuracy of 72\u200a%. To improve sensitivity and specificity in classification of esophageal varices, we propose using a modified score. This score detected esophageal varices with 100\u200a% sensitivity, 93\u200a% specificity, 94\u200a% PPV, and 100\u200a% NPV, giving a total overall accuracy of 97\u200a%. All patients preferred ECE over EGD. No capsule retention was recorded.<\/jats:p><jats:p>\n          Conclusions\u2002ECE is a well-tolerated and safe procedure in children. Using the modified score, the sensitivity of ECE is currently sufficient to detect esophageal varices and replace EGD in infants with suspicion of esophageal varices or when EGD is refused.<\/jats:p>","DOI":"10.1055\/a-0647-1709","type":"journal-article","created":{"date-parts":[[2019,1,2]],"date-time":"2019-01-02T09:24:39Z","timestamp":1546421079000},"page":"10-17","source":"Crossref","is-referenced-by-count":21,"title":["Screening of esophageal varices in children using esophageal capsule endoscopy: a multicenter prospective study"],"prefix":"10.1055","volume":"51","clinical-trial-number":[{"clinical-trial-number":"nct01551966","registry":"10.18810\/clinical-trials-gov"}],"author":[{"given":"Jacques","family":"Cardey","sequence":"additional","affiliation":[{"name":"Gastroent\u00e9rologie, h\u00e9patologie, nutrition p\u00e9diatrique, H\u00f4pital Necker-Enfants malades, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catherine","family":"Le Gall","sequence":"additional","affiliation":[{"name":"Hospices Civils de Lyon, H\u00f4pital Femme M\u00e8re Enfant, H\u00e9patologie, gastroent\u00e9rologie et nutrition p\u00e9diatrique, Lyon, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laurent","family":"Michaud","sequence":"additional","affiliation":[{"name":"Gastroent\u00e9rologie p\u00e9diatrique, CHRU Lille, Lille, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alain","family":"Dabadie","sequence":"additional","affiliation":[{"name":"H\u00e9patologie, gastroent\u00e9rologie et nutrition p\u00e9diatrique, CHU H\u00f4pital Sud, Rennes, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C\u00e9cile","family":"Talbotec","sequence":"additional","affiliation":[{"name":"Gastroent\u00e9rologie, h\u00e9patologie, nutrition p\u00e9diatrique, H\u00f4pital Necker-Enfants malades, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marc","family":"Bellaiche","sequence":"additional","affiliation":[{"name":"Gastroent\u00e9rologie et nutrition p\u00e9diatrique, H\u00f4pital Robert Debr\u00e9, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thierry","family":"Lamireau","sequence":"additional","affiliation":[{"name":"Gastroent\u00e9rologie p\u00e9diatrique, CHU Bordeaux, Bordeaux, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emmanuel","family":"Mas","sequence":"additional","affiliation":[{"name":"Gastroent\u00e9rologie, h\u00e9patologie, nutrition, diab\u00e9tologie p\u00e9diatrique, CHU Toulouse, Toulouse, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laure","family":"Bridoux-Henno","sequence":"additional","affiliation":[{"name":"H\u00e9patologie, gastroent\u00e9rologie et nutrition p\u00e9diatrique, CHU H\u00f4pital Sud, Rennes, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jerome","family":"Viala","sequence":"additional","affiliation":[{"name":"Gastroent\u00e9rologie et nutrition p\u00e9diatrique, H\u00f4pital Robert Debr\u00e9, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lioara","family":"Restier-Miron","sequence":"additional","affiliation":[{"name":"Hospices Civils de Lyon, H\u00f4pital Femme M\u00e8re Enfant, H\u00e9patologie, gastroent\u00e9rologie et nutrition p\u00e9diatrique, Lyon, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alain","family":"Lachaux","sequence":"additional","affiliation":[{"name":"Hospices Civils de Lyon, H\u00f4pital Femme M\u00e8re Enfant, H\u00e9patologie, gastroent\u00e9rologie et nutrition p\u00e9diatrique, Lyon, France"},{"name":"Universit\u00e9 Cl Bernard Lyon 1, Lyon, France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2018,9,5]]},"container-title":["Endoscopy"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-0647-1709.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,1,17]],"date-time":"2019-01-17T16:23:44Z","timestamp":1547742224000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-0647-1709"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,9,5]]},"references-count":0,"journal-issue":{"issue":"01","published-online":{"date-parts":[[2018,12,20]]},"published-print":{"date-parts":[[2019,1]]}},"URL":"https:\/\/doi.org\/10.1055\/a-0647-1709","relation":{},"ISSN":["0013-726X","1438-8812"],"issn-type":[{"value":"0013-726X","type":"print"},{"value":"1438-8812","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,9,5]]}}}