{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T22:20:23Z","timestamp":1762899623427},"reference-count":0,"publisher":"Georg Thieme Verlag KG","issue":"03","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ultraschall Med"],"published-print":{"date-parts":[[2020,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Purpose\u2002To investigate hemodynamic effects after antenatal corticosteroids (ACS) administration in appropriate for gestational age (AGA) and early growth restricted (GR) fetuses by measurement of Doppler cardiovascular function parameters.<\/jats:p><jats:p>\n          Materials and Methods\u2002Prospective cohort study. AGA and GR singleton pregnancies receiving ACS for fetal lung maturation between 24\u200a+\u200a0\u201333\u200a+\u200a6 weeks were enrolled. Feto-placental vascular hemodynamics were studied by: umbilical artery (UA) pulsatility index (PI), middle cerebral artery (MCA) PI, renal artery (RenA) PI. Cardiac function was evaluated by ductus venosus (DV) PI and by echocardiographic parameters: E to A wave ratios (E\/A) and mitral and tricuspid annular plane systolic excursion (MAPSE and TAPSE) for diastolic function, left and right myocardial performance index (MPI) for overall (diastolic and systolic) function. A single operator performed all the measurements at 3 different time points (E): E0 before or within 4 hours of ACS administration (baseline examination), E1 24\u201348 hours after the first dose and E2 7 days after the second dose of ACS.\u200aThe values were expressed as z-scores. Pairwise comparisons with paired t-test were performed to compare measurements before and after exposure to ACS.<\/jats:p><jats:p>\n          Results\u200225 AGA and 20 GR fetuses (mean gestational age: 31\u200a+\u200a1 and 30\u200a+\u200a6, respectively) were included in the analysis. In the AGA group ACS administration was associated with a significant reduction in UA PI. In the GR fetuses ACS temporarily (E0-E1) restored UA-end diastolic flow (EDF) in 6 of 9 fetuses with A\/R-EDF (\u201cReturn of EDF phenomenon\u201d) and produced a significant increase (worsening) in right MPI (both in E1-E2 and in E0-E2).<\/jats:p><jats:p>\n          Conclusion\u2002ACS administration is associated with UA vasodilation in both AGA and GR fetuses and with an increase in right MPI in the latter group.\u200aThis suggests a worsening in cardiac function in GR fetuses.<\/jats:p>","DOI":"10.1055\/a-0654-4824","type":"journal-article","created":{"date-parts":[[2018,10,26]],"date-time":"2018-10-26T22:45:01Z","timestamp":1540593901000},"page":"292-299","source":"Crossref","is-referenced-by-count":8,"title":["Cardiovascular Hemodynamic Changes After Antenatal Corticosteroids in Growth Restricted and Appropriate for Gestational\u00a0Age Fetuses"],"prefix":"10.1055","volume":"41","author":[{"given":"Laura","family":"Marchi","sequence":"additional","affiliation":[{"name":"Department for Women and Child Health, Azienda Ospedaliera Universitaria Careggi, Firenze, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucia","family":"Pasquini","sequence":"additional","affiliation":[{"name":"Department for Women and Child Health, Azienda Ospedaliera Universitaria Careggi, Firenze, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ayten","family":"Elvan-Taspinar","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, University Medical Center Groningen, University of Groningen, Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caterina Maddalena","family":"Bilardo","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Vrije Universiteit Amsterdam, Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2018,10,26]]},"container-title":["Ultraschall in der Medizin - European Journal of Ultrasound"],"original-title":[],"language":"de","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-0654-4824.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,6,8]],"date-time":"2020-06-08T22:32:59Z","timestamp":1591655579000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-0654-4824"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10,26]]},"references-count":0,"journal-issue":{"issue":"03","published-online":{"date-parts":[[2020,6,8]]},"published-print":{"date-parts":[[2020,6]]}},"URL":"https:\/\/doi.org\/10.1055\/a-0654-4824","relation":{},"ISSN":["0172-4614","1438-8782"],"issn-type":[{"value":"0172-4614","type":"print"},{"value":"1438-8782","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,10,26]]}}}