{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T21:56:55Z","timestamp":1785880615351,"version":"3.56.0"},"reference-count":0,"publisher":"Georg Thieme Verlag KG","issue":"03","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Drug Res (Stuttg)"],"published-print":{"date-parts":[[2019,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\nPurpose Ocimum gratissimum L. leaves has been traditionally used for management of febrile illnesses and symptoms typified of sickness behavior. In this work we investigated the modulatory effect of flavonoid-rich fraction of O. gratissimum leaves (EAFOg) on sickness behavior, inflammatory and oxidative stress responses in LPS-challenged mice.<\/jats:p><jats:p>\nMethod O. gratissimum leaf was first extracted with n-hexane, chloroform and methanol, and EAFOg was obtained by ethylacetate partitioning of a sequentially resultant methanol extract. The effect of EAFOg (25\u2013100\u2009mg\/kg) on acute LPS-induced neurobehavioral impairment in an open field test (OFT) and depressive-like behavior in forced swimming test (FST) was investigated. Serum nitrite and TNF-\u03b1, as well as myeloperoxidase (MPO), malondialdehyde (MDA), and reduced glutathione (GSH) levels were determined in liver and brain tissues.<\/jats:p><jats:p>\nResult EAFOg prevented the reduction in locomotor and rearing activity in OFT and the increase in immobility time in FST. The fraction significantly attenuated the elevation of serum TNF- \u03b1 and nitrite levels. EAFOg reversed LPS-induced increase in MDA, MPO, and nitrite levels and attenuated GSH depletion in liver and brain tissues of mice.<\/jats:p><jats:p>\nConclusion Flavonoid-rich fraction of O. gratissimum leaf demonstrated significant modulation of LPS-induced sickness behavior, inflammatory and oxidative stress response in mice. This suggests an important therapeutic strategy in slowing down LPS-mediated hepatic and neuronal disease processes.<\/jats:p>","DOI":"10.1055\/a-0654-5042","type":"journal-article","created":{"date-parts":[[2018,7,31]],"date-time":"2018-07-31T18:52:44Z","timestamp":1533063164000},"page":"151-158","source":"Crossref","is-referenced-by-count":16,"title":["Flavonoid-Rich Fraction of Ocimum gratissimum Attenuates Lipopolysaccharide-Induced Sickness Behavior, Inflammatory and Oxidative Stress in Mice"],"prefix":"10.1055","volume":"69","author":[{"given":"Abayomi","family":"Ajayi","sequence":"additional","affiliation":[{"name":"Department of Pharmacology & Therapeutics, College of Medicine, University of Ibadan, Ibadan, Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benneth","family":"Ben-Azu","sequence":"additional","affiliation":[{"name":"Department of Pharmacology & Therapeutics, College of Medicine, University of Ibadan, Ibadan, Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel","family":"Onasanwo","sequence":"additional","affiliation":[{"name":"Department of Physiology, College of Medicine, University of Ibadan, Ibadan, Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olusegun","family":"Adeoluwa","sequence":"additional","affiliation":[{"name":"Department of Pharmacology & Therapeutics, College of Medicine, University of Ibadan, Ibadan, Nigeria"},{"name":"Department of Pharmacology & Therapeutics, Afe Babalola University Ado-Ekiti, Ado-Ekiti, Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony","family":"Eduviere","sequence":"additional","affiliation":[{"name":"Department of Pharmacology & Therapeutics, College of Medicine, University of Ibadan, Ibadan, Nigeria"},{"name":"Department of Pharmacology & Therapeutics, University of Medical Sciences, Ondo, Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olusegun","family":"Ademowo","sequence":"additional","affiliation":[{"name":"Department of Pharmacology & Therapeutics, College of Medicine, University of Ibadan, Ibadan, Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2018,7,31]]},"container-title":["Drug Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-0654-5042.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,2,26]],"date-time":"2019-02-26T20:14:02Z","timestamp":1551212042000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-0654-5042"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,7,31]]},"references-count":0,"journal-issue":{"issue":"03","published-online":{"date-parts":[[2019,2,22]]},"published-print":{"date-parts":[[2019,3]]}},"URL":"https:\/\/doi.org\/10.1055\/a-0654-5042","relation":{},"ISSN":["2194-9379","2194-9387"],"issn-type":[{"value":"2194-9379","type":"print"},{"value":"2194-9387","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,7,31]]}}}