{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T16:58:11Z","timestamp":1783011491487,"version":"3.54.6"},"reference-count":0,"publisher":"Georg Thieme Verlag KG","issue":"05","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Exp Clin Endocrinol Diabetes"],"published-print":{"date-parts":[[2020,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Diabetes type 1 (T1D) is a common autoimmune disease characterized by\n                        permanent destruction of the insulin-secreting \u03b2-cells in pancreatic\n                        islets, resulting in a deficiency of the glucose-lowering hormone insulin\n                        and persisting high blood glucose levels. Insulin has to be replaced by\n                        regular subcutaneous injections, and blood glucose level must be monitored\n                        due to the risk of hyperglycemia. Recently, transplantation of new\n                        pancreatic \u03b2-cells into T1D patients has come to be considered one\n                        of the most potentially effective treatments for this disease. Therefore,\n                        much effort has focused on understanding the regulation of \u03b2-cells.\n                        Induced pluripotent stem cells (iPSCs) represent a valuable source for T1D\n                        modelling and cell replacement therapy because of their ability to\n                        differentiate into all cell types in vitro. Recent advances in stem\n                        cell-based therapy and gene-editing tools have enabled the generation of\n                        functionally adult pancreatic \u03b2-cells derived from iPSCs. Although\n                        animal and human pancreatic development and \u03b2-cell physiology have\n                        significant differences, animal models represent an important tool in\n                        evaluating the therapeutic potential of iPSC-derived \u03b2-cells on type\n                        1 diabetes treatment. This review outlines the recent progress in\n                        iPSC-derived \u03b2-cell differentiation methods, disease modelling, and\n                        future perspectives.<\/jats:p>","DOI":"10.1055\/a-0661-5873","type":"journal-article","created":{"date-parts":[[2018,8,16]],"date-time":"2018-08-16T23:01:58Z","timestamp":1534460518000},"page":"339-346","source":"Crossref","is-referenced-by-count":6,"title":["Generation of Pancreatic \u03b2-cells From iPSCs and their\n                    Potential for Type 1 Diabetes Mellitus Replacement Therapy and\n                    Modelling"],"prefix":"10.1055","volume":"128","author":[{"given":"Maria","family":"Csobonyeiova","sequence":"additional","affiliation":[{"name":"Institute of Histology and Embryology, Faculty of Medicine, Comenius\n                    University in Bratislava, Bratislava, Slovakia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Polak","sequence":"additional","affiliation":[{"name":"Institute of Histology and Embryology, Faculty of Medicine, Comenius\n                    University in Bratislava, Bratislava, Slovakia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lubos","family":"Danisovic","sequence":"additional","affiliation":[{"name":"Institute of Medical Biology, Genetics and Clinical Genetics, Faculty\n                    of Medicine, Comenius University in Bratislava, Bratislava,\n                    Slovakia"},{"name":"REGENMED Ltd., Bratislava, Slovakia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2018,8,16]]},"container-title":["Experimental and Clinical Endocrinology &amp; Diabetes"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-0661-5873.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,6]],"date-time":"2020-05-06T22:36:11Z","timestamp":1588804571000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-0661-5873"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,8,16]]},"references-count":0,"journal-issue":{"issue":"05","published-online":{"date-parts":[[2020,5,6]]},"published-print":{"date-parts":[[2020,5]]}},"URL":"https:\/\/doi.org\/10.1055\/a-0661-5873","relation":{},"ISSN":["0947-7349","1439-3646"],"issn-type":[{"value":"0947-7349","type":"print"},{"value":"1439-3646","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,8,16]]}}}