{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T19:18:37Z","timestamp":1788031117527,"version":"build-2784847793"},"reference-count":0,"publisher":"Georg Thieme Verlag KG","issue":"08","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Exp Clin Endocrinol Diabetes"],"published-print":{"date-parts":[[2020,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n                        Aim To evaluate the effect of dapagliflozin on insulin secretion and\n                        insulin sensitivity in patients with prediabetes.<\/jats:p><jats:p>\n                        Methods A randomized, double-blind, placebo-controlled clinical trial\n                        was carried out in 24 adults diagnosed with prediabetes and without\n                        pharmacological treatment. Patients were randomly assigned into two groups\n                        of 12 patients each to receive 10\u2009mg of oral dapagliflozin or\n                        placebo once a day during 12 weeks. At baseline and at the end of the study,\n                        anthropometric and metabolic measurements were evaluated, including the\n                        first phase of insulin secretion, total insulin secretion, and insulin\n                        sensitivity.<\/jats:p><jats:p>\n                        Results After dapagliflozin administration, there were significant\n                        decreases in body weight (80.8\u00b116.3 vs.\n                        77.8\u00b114.9\u2009kg, p=0.019), body mass index\n                        (30.3\u00b13.5 vs. 29.2\u00b13.1\u2009kg\/m2,\n                        p=0.023), waist circumference (100.6\u00b113.5 vs.\n                        96.2\u00b111.8\u2009cm, p=0.003), fasting glucose\n                        (5.9\u00b10.4 vs. 5.1\u00b10.3\u2009mmol\/L,\n                        p&lt;0.001) and uric acid (334.3\u00b170.8 vs.\n                        262.9\u00b160.7\u2009mmol\/L, p=0.032), with a tendency\n                        to increase the insulin sensitivity (1.94\u00b10.72 vs.\n                        2.63\u00b11.04, p=0.064).<\/jats:p><jats:p>\n                        Conclusion Dapagliflozin administration in patients with prediabetes\n                        decreased body weight, body mass index, waist circumference, fasting\n                        glucose, and uric acid, with a tendency to increase the insulin sensitivity\n                        without changes in insulin secretion.<\/jats:p>","DOI":"10.1055\/a-0664-7583","type":"journal-article","created":{"date-parts":[[2018,8,27]],"date-time":"2018-08-27T23:31:11Z","timestamp":1535412671000},"page":"506-511","source":"Crossref","is-referenced-by-count":49,"title":["Effect of Dapagliflozin on Insulin Secretion and Insulin Sensitivity\n                    in Patients with Prediabetes"],"prefix":"10.1055","volume":"128","author":[{"given":"Alejandra M.","family":"Ram\u00edrez-Rodr\u00edguez","sequence":"additional","affiliation":[{"name":"Institute of Experimental and Clinical Therapeutics, Department of\n                    Physiology, Health Sciences University Center, University of Guadalajara,\n                    Guadalajara, Jalisco, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"Gonz\u00e1lez-Ortiz","sequence":"additional","affiliation":[{"name":"Institute of Experimental and Clinical Therapeutics, Department of\n                    Physiology, Health Sciences University Center, University of Guadalajara,\n                    Guadalajara, Jalisco, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esperanza","family":"Mart\u00ednez-Abundis","sequence":"additional","affiliation":[{"name":"Institute of Experimental and Clinical Therapeutics, Department of\n                    Physiology, Health Sciences University Center, University of Guadalajara,\n                    Guadalajara, Jalisco, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2018,8,27]]},"container-title":["Experimental and Clinical Endocrinology &amp; Diabetes"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-0664-7583.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,7,31]],"date-time":"2020-07-31T22:44:20Z","timestamp":1596235460000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-0664-7583"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,8,27]]},"references-count":0,"journal-issue":{"issue":"08","published-online":{"date-parts":[[2020,7,31]]},"published-print":{"date-parts":[[2020,8]]}},"URL":"https:\/\/doi.org\/10.1055\/a-0664-7583","relation":{},"ISSN":["0947-7349","1439-3646"],"issn-type":[{"value":"0947-7349","type":"print"},{"value":"1439-3646","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,8,27]]}}}