{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T09:33:09Z","timestamp":1759743189714},"reference-count":87,"publisher":"Georg Thieme Verlag KG","issue":"07","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Horm Metab Res"],"published-print":{"date-parts":[[2019,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Pheochromocytomas are rare neuroendocrine tumors of the adrenal gland, whereas any extra-adrenal tumor with similar histology is designated as paraganglioma. These tumors have a very high rate of germline mutations in a large number of genes, up to 35% to 40%, frequently predisposing for other tumors as well. Therefore, they represent a phenomenal challenge for treating physicians. This review focuses on pheochromocytomas only, with special attention to gross and microscopic clues to the diagnosis of genetic syndromes, including the role of succinate dehydrogenase subunit A and subunit B immunohistochemistry as surrogate markers for genetic analysis in the field of succinate dehydrogenase subunit gene mutations.<\/jats:p>","DOI":"10.1055\/a-0672-1266","type":"journal-article","created":{"date-parts":[[2018,8,24]],"date-time":"2018-08-24T22:44:41Z","timestamp":1535150681000},"page":"403-413","source":"Crossref","is-referenced-by-count":6,"title":["An Update on the Histology of Pheochromocytomas: How Does it Relate to Genetics?"],"prefix":"10.1055","volume":"51","author":[{"given":"Lindsey","family":"Oudijk","sequence":"additional","affiliation":[{"name":"Department of Pathology, Erasmus MC University Medical Center, Rotterdam, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9","family":"Gaal","sequence":"additional","affiliation":[{"name":"Department of Pathology, Isala Clinics, Zwolle, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karen","family":"Koopman","sequence":"additional","affiliation":[{"name":"Department of Pathology, Isala Clinics, Zwolle, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ronald R.","family":"de Krijger","sequence":"additional","affiliation":[{"name":"Department of Pathology, University Medical Center\/Princess Maxima Center for Pediatric Oncology, Utrecht and Reinier de Graaf Hospital, Delft, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2018,8,24]]},"reference":[{"key":"ref1","volume-title":"WHO Classification of tumours of endocrine organs","author":"O 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