{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T19:58:55Z","timestamp":1789415935920,"version":"build-2803163510"},"reference-count":0,"publisher":"Georg Thieme Verlag KG","issue":"03","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Planta Med"],"published-print":{"date-parts":[[2019,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In an in vitro screening for anti-influenza agents from European polypores, the fruit body extract of Gloeophyllum odoratum dose-dependently inhibited the cytopathic effect of the H3N2 influenza virus A\/Hong Kong\/68 (HK\/68) in Madin Darby canine kidney cells with a 50% inhibitory concentration (IC50) of 15\u2009\u00b5g\/mL, a noncytotoxic concentration. After a chromatographic work-up, eight lanostane triterpenes (1\u20138) were isolated and their structures were elucidated based on high-resolution electrospray ionization mass spectrometry analyses, and one- and two-dimensional nuclear magnetic resonance experiments. Constituents 1 (gloeophyllin K) and 2 (gloeophyllin L) are reported here for the first time, and compounds 5, 7, and 8 have not been described for the investigated fungal material so far. The highest activity was determined for trametenolic acid B (3) against HK\/68 and the 2009 pandemic H1N1 strain A\/Jena\/8178\/09 with IC50 values of 14 and 11\u2009\u00b5M, respectively. In a plaque reduction assay, this compound was able to bind to cell-free viruses and to neutralize their infectivity.<\/jats:p>","DOI":"10.1055\/a-0690-9236","type":"journal-article","created":{"date-parts":[[2018,8,21]],"date-time":"2018-08-21T22:59:57Z","timestamp":1534892397000},"page":"195-202","source":"Crossref","is-referenced-by-count":14,"title":["Lanostane Triterpenes from Gloeophyllum odoratum and Their Anti-Influenza Effects"],"prefix":"10.1055","volume":"85","author":[{"given":"Ulrike","family":"Grienke","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy, Faculty of Life Sciences, University of Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Zwirchmayr","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy, Faculty of Life Sciences, University of Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ursula","family":"Peintner","sequence":"additional","affiliation":[{"name":"Institute of Microbiology, University of Innsbruck, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ernst","family":"Urban","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry, Faculty of Life Sciences, University of Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Zehl","sequence":"additional","affiliation":[{"name":"Department of Analytical Chemistry, Faculty of Chemistry, University of Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michaela","family":"Schmidtke","sequence":"additional","affiliation":[{"name":"Institute of Medical Microbiology, Section Experimental Virology, Jena University Hospital, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judith","family":"Rollinger","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy, Faculty of Life Sciences, University of Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2018,8,21]]},"container-title":["Planta Medica"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-0690-9236.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,2,5]],"date-time":"2019-02-05T23:43:08Z","timestamp":1549410188000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-0690-9236"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,8,21]]},"references-count":0,"journal-issue":{"issue":"03","published-online":{"date-parts":[[2019,2,5]]},"published-print":{"date-parts":[[2019,2]]}},"URL":"https:\/\/doi.org\/10.1055\/a-0690-9236","relation":{},"ISSN":["0032-0943","1439-0221"],"issn-type":[{"value":"0032-0943","type":"print"},{"value":"1439-0221","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,8,21]]}}}