{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,12,6]],"date-time":"2023-12-06T14:43:36Z","timestamp":1701873816965},"reference-count":0,"publisher":"Georg Thieme Verlag KG","issue":"02","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pneumologie"],"published-print":{"date-parts":[[2019,2]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title><jats:p>Das Lungenemphysem ist definiert als irreversible Erweiterung des Luftraums distal der terminalen Bronchiolen. Die kleinen Atemwege &lt;\u200a2\u200amm Durchmesser sind der Bereich, bei dem es bei Patienten mit einer chronischen obstruktiven Atemwegserkrankung (COPD) zu einer chronischen Inflammation mit bronchialer Obstruktion kommt. 80\u200a\u2013\u200a90\u200a% der terminalen Bronchiolen sind bei Patienten mit schwergradiger COPD zerst\u00f6rt. Neuere Daten belegen, dass bereits bei leichter bis moderater COPD GOLD 1 und 2 etwa 40\u200a% der terminalen und 60\u200a% der transitionalen Bronchiolen destruiert sind. Morphologische Zeichen des Emphysems weisen diese Patienten jedoch noch nicht auf. Erst bei einer kritischen Prozentzahl zerst\u00f6rter terminaler und respiratorischer Bronchiolen scheint es zum Auftreten einer klinischen Symptomatik sowie zur Emphysementstehung zu kommen.<\/jats:p>","DOI":"10.1055\/a-0730-0216","type":"journal-article","created":{"date-parts":[[2018,12,3]],"date-time":"2018-12-03T18:49:02Z","timestamp":1543862942000},"page":"81-86","source":"Crossref","is-referenced-by-count":1,"title":["Die Pathophysiologie des Lungenemphysems \u2013 La\u00ebnnec (1781\u20131826) hatte Recht!"],"prefix":"10.1055","volume":"73","author":[{"given":"U.","family":"Koehler","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Innere Medizin,SP Pneumologie, Intensiv- und Schlafmedizin, Philipps-Universit\u00e4t Marburg, Marburg"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"O.","family":"Hildebrandt","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Innere Medizin,SP Pneumologie, Intensiv- und Schlafmedizin, Philipps-Universit\u00e4t Marburg, Marburg"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Dittrich","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Innere Medizin,SP Pneumologie, Intensiv- und Schlafmedizin, Philipps-Universit\u00e4t Marburg, Marburg"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Koehler","sequence":"additional","affiliation":[{"name":"Fachbereich Gesundheit,Technische Hochschule Mittelhessen, Gie\u00dfen"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Weissflog","sequence":"additional","affiliation":[{"name":"Clinical Research, Thora Tech GmbH, Anwenderzentrum f\u00fcr Medizintechnik, Gie\u00dfen"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2018,12,3]]},"container-title":["Pneumologie"],"original-title":[],"language":"de","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-0730-0216.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,2,13]],"date-time":"2019-02-13T18:58:06Z","timestamp":1550084286000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-0730-0216"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,12,3]]},"references-count":0,"journal-issue":{"issue":"02","published-online":{"date-parts":[[2019,2,13]]},"published-print":{"date-parts":[[2019,2]]}},"URL":"https:\/\/doi.org\/10.1055\/a-0730-0216","relation":{},"ISSN":["0934-8387","1438-8790"],"issn-type":[{"value":"0934-8387","type":"print"},{"value":"1438-8790","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,12,3]]}}}