{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T22:29:35Z","timestamp":1777674575447,"version":"3.51.4"},"reference-count":0,"publisher":"Georg Thieme Verlag KG","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Exp Clin Endocrinol Diabetes"],"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\nAims Early identification of individuals with insulin resistance (IR) and metabolically unhealthy state can help prevent various diseases and improve quality of life. In this study, we investigated a possible marker of IR and metabolic health status, alanine aminotransferase\/aspartate aminotransferase (ALT\/AST) ratio, and aimed to confirm its feasibility in a large population study.<\/jats:p><jats:p>\nMethods A total of 16,371 adults from Korean National Health and Examination Survey were studied. Participants were divided into four groups according to their ALT\/AST ratio quartiles. The homeostatic model assessment of insulin resistance level and proportion of people with IR, impaired fasting glucose, and undiagnosed type 2 diabetes were compared for each group. Receiver-operating characteristics (ROC) curve was also used to assess the usefulness of ALT\/AST ratio to identify individuals with IR and metabolically unhealthy.<\/jats:p><jats:p>\nResults In the groups with higher ALT\/AST ratio, HOMA-IR level, proportion of IR, and proportion of individuals with IFG or type 2 diabetes mellitus was higher than that in those with low ALT\/AST ratio. When analyzed with other factors related to IR, the data showed that the ALT\/AST ratio was an independent predictor of IR (odds ratio 1.363, 95% confidential interval 1.323\u20131.405, p&lt;0.001). When ROC curve analysis was done, area under curve (AUC) for identifying individuals with IR was 0.634. In addition, metabolically unhealthy individuals showed significantly higher ALT\/AST ratio than metabolically healthy individuals (0.9780 vs 0.8511, p&lt;0.001).<\/jats:p><jats:p>\nConclusions ALT\/AST ratio was well-correlated with IR, IR-related conditions, and metabolic health status. This easily accessible method to estimate IR may facilitate the early screening of IR, which can result in prevention of IR-related morbid conditions.<\/jats:p>","DOI":"10.1055\/a-0752-0217","type":"journal-article","created":{"date-parts":[[2018,10,26]],"date-time":"2018-10-26T18:45:42Z","timestamp":1540579542000},"page":"677-684","source":"Crossref","is-referenced-by-count":20,"title":["A High Alanine Aminotransferase\/Aspartate Aminotransferase Ratio Determines Insulin Resistance and Metabolically Healthy\/Unhealthy Obesity in a General Adult Population in Korea: The Korean National Health and Nutritional Examination Survey 2007\u20132010"],"prefix":"10.1055","volume":"127","author":[{"given":"Soon Sung","family":"Kwon","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Yonsei University College of Medicine, Seoul, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sang-Guk","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Yonsei University College of Medicine, Seoul, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2018,10,26]]},"container-title":["Experimental and Clinical Endocrinology &amp; Diabetes"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-0752-0217.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,11,4]],"date-time":"2019-11-04T18:38:32Z","timestamp":1572892712000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-0752-0217"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10,26]]},"references-count":0,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2019,11,4]]},"published-print":{"date-parts":[[2019,10]]}},"URL":"https:\/\/doi.org\/10.1055\/a-0752-0217","relation":{},"ISSN":["0947-7349","1439-3646"],"issn-type":[{"value":"0947-7349","type":"print"},{"value":"1439-3646","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,10,26]]}}}