{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T00:11:34Z","timestamp":1784851894331,"version":"3.55.0"},"reference-count":0,"publisher":"Georg Thieme Verlag KG","issue":"08","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Exp Clin Endocrinol Diabetes"],"published-print":{"date-parts":[[2020,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n                    Background Age-related bone deteriorations are the common endocrine\n                    disorders in the elderly population, leading to an increased risk of fractures.\n                    Therefore, effective treatment strategies provide a way to prevent bone loss and\n                    improve the quality of life in the elderly population. The present study aimed\n                    to investigate the anti-osteoporotic effects of doxercalciferol (DOX) in aging\n                    mice.<\/jats:p><jats:p>\n                    Methods Bone metabolism-related markers were measured by ELISA assay. The\n                    expression of bone formation and resorption-related genes was performed by\n                    RT-qPCR analysis. Hematoxylin and eosin (H&amp;E) and Safranin O staining\n                    were performed to analyze the trabecular bone and cartilage degeneration.<\/jats:p><jats:p>\n                    Results Aging resulted in urine ca2+ excretion, a decrease in\n                    bone ca2+ content and reduction of biomechanical strength in mice. We\n                    also found that the level of PTH was increased in aging mice, while DOX\n                    administration markedly down-regulated serum PTH in aging mice. H&amp;E and\n                    Safranin O staining showed that DOX protected against aging-induced bone loss\n                    and cartilage regeneration in the tibia from aging mice. Furthermore, DOX\n                    treatment resulted in an increase in Runx2, osterix and Col1a1 mRNA expression\n                    and a decrease in Ctsk, MMP-9 and CAII mRNA expression in the tibia from aging\n                    mice.<\/jats:p><jats:p>\n                    Conclusion These findings indicated that DOX had a beneficial effect on\n                    age-related bone deteriorations in aging mice by promoting osteoblast activity\n                    and cartilage regeneration and inhibiting osteoclast-specific genes\n                    expression.<\/jats:p>","DOI":"10.1055\/a-0754-1956","type":"journal-article","created":{"date-parts":[[2018,10,31]],"date-time":"2018-10-31T23:58:39Z","timestamp":1541030319000},"page":"540-547","source":"Crossref","is-referenced-by-count":4,"title":["Doxercalciferol Alleviates Bone Deteriorations and Cartilage\n                    Degeneration in Aging Mice"],"prefix":"10.1055","volume":"128","author":[{"given":"Jian","family":"Li","sequence":"first","affiliation":[{"name":"Department of Geriatric Endocrinology, Chinese PLA\n                    General Hospital, National Clinical Center of Geriatric\n                    Medicine, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nan","family":"Li","sequence":"first","affiliation":[{"name":"Department of Geriatric Endocrinology, Chinese PLA\n                    General Hospital, National Clinical Center of Geriatric\n                    Medicine, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuangtong","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Geriatric Endocrinology, Chinese PLA\n                    General Hospital, National Clinical Center of Geriatric\n                    Medicine, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minyan","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Geriatric Endocrinology, Chinese PLA\n                    General Hospital, National Clinical Center of Geriatric\n                    Medicine, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Banruo","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Geriatric Endocrinology, Chinese PLA\n                    General Hospital, National Clinical Center of Geriatric\n                    Medicine, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanhui","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Geriatric Endocrinology, Chinese PLA\n                    General Hospital, National Clinical Center of Geriatric\n                    Medicine, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yinghong","family":"Shao","sequence":"additional","affiliation":[{"name":"Department of Outpatient, Chinese PLA General\n                    Hospital, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2018,10,31]]},"container-title":["Experimental and Clinical Endocrinology &amp; Diabetes"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-0754-1956.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,7,31]],"date-time":"2020-07-31T22:44:29Z","timestamp":1596235469000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-0754-1956"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10,31]]},"references-count":0,"journal-issue":{"issue":"08","published-online":{"date-parts":[[2020,7,31]]},"published-print":{"date-parts":[[2020,8]]}},"URL":"https:\/\/doi.org\/10.1055\/a-0754-1956","relation":{},"ISSN":["0947-7349","1439-3646"],"issn-type":[{"value":"0947-7349","type":"print"},{"value":"1439-3646","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,10,31]]}}}