{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T16:20:48Z","timestamp":1778948448190,"version":"3.51.4"},"reference-count":0,"publisher":"Georg Thieme Verlag KG","issue":"09","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Endoscopy"],"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Backgrounds\u2002The placement of a self-expandable metal stent (SEMS) is widely used in patients with unresectable malignant biliary obstructions, but SEMSs are susceptible to occlusion by tumor ingrowth or overgrowth. The efficacy and safety of a novel paclitaxel-eluting biliary metal stent incorporating sodium caprate (MSCPM-III) were compared prospectively with those of a covered metal stent (CMS) in patients with malignant biliary obstructions.<\/jats:p><jats:p>\n          Methods\u2002Patients with unresectable distal malignant biliary obstructions (n\u200a=\u200a106) were prospectively enrolled in this study at multiple treatment centers. Stents were placed endoscopically: MSCPM-III in 54 patients and CMS in 51 patients. The patients received systemic chemotherapy regimens according to their disease characteristics.<\/jats:p><jats:p>\n          Results\u2002The two groups did not differ significantly in basic characteristics or mean follow-up period. Stent occlusion occurred in 14 patients who received MSCPM-III and in 11 patients who received CMS.\u200aTime to recurrent biliary obstruction (RBO) and survival time did not differ significantly between the two groups (P \u200a=\u200a0.84 and P\u200a=\u200a0.29, respectively). However, tumor size at 2 months after stent insertion was significantly decreased in patients in the MSCPM-III group with bile duct cancers or those who experienced stent migration compared with the CMS group.\u200aComplications, including cholangitis and pancreatitis, were found to be acceptable in both groups.<\/jats:p><jats:p>\n          Conclusions\u2002Although compared with a CMS the MSCPM-III did not significantly influence time to RBO or survival duration in patients with malignant biliary obstructions, MSCPM-III reduced tumor volume and was used safely in humans.<\/jats:p>","DOI":"10.1055\/a-0754-5763","type":"journal-article","created":{"date-parts":[[2018,11,10]],"date-time":"2018-11-10T01:49:44Z","timestamp":1541814584000},"page":"843-851","source":"Crossref","is-referenced-by-count":23,"title":["Efficacy of a paclitaxel-eluting biliary metal stent with sodium caprate in malignant biliary obstruction: a prospective randomized comparative study"],"prefix":"10.1055","volume":"51","clinical-trial-number":[{"clinical-trial-number":"nct02460432","registry":"10.18810\/clinical-trials-gov"}],"author":[{"given":"Sung Ill","family":"Jang","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyu Taek","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jung Sik","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Busan Paik Hospital Inje University College of Medicine, Pusan, South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seok","family":"Jeong","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Inha University College of Medicine, Incheon, South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Don Haeng","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Inha University College of Medicine, Incheon, South Korea"},{"name":"Utah-Inha DDS and Advanced Therapeutics Research Center, Incheon, South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong Tae","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Seoul National University College of Medicine, Seoul, South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sang Hyub","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Seoul National University College of Medicine, Seoul, South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeong-Sik","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Radiology, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dong Ki","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2018,11,9]]},"container-title":["Endoscopy"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-0754-5763.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,28]],"date-time":"2019-08-28T22:31:40Z","timestamp":1567031500000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-0754-5763"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,11,9]]},"references-count":0,"journal-issue":{"issue":"09","published-online":{"date-parts":[[2019,8,28]]},"published-print":{"date-parts":[[2019,9]]}},"URL":"https:\/\/doi.org\/10.1055\/a-0754-5763","relation":{},"ISSN":["0013-726X","1438-8812"],"issn-type":[{"value":"0013-726X","type":"print"},{"value":"1438-8812","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,11,9]]}}}