{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T03:51:31Z","timestamp":1784173891576,"version":"3.55.0"},"reference-count":23,"publisher":"Georg Thieme Verlag KG","issue":"05","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ultraschall Med"],"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Purpose\u2002The aim of this study was to describe the sonographic evolution of fetal head circumference (HC) and width of the posterior horn of the lateral ventricle (Vp) after open fetal myelomeningocele (fMMC) repair and to assess whether pre- or postoperative measurements are helpful to predict the need for shunting during the first year of life.<\/jats:p><jats:p>\n          Patients &amp; Methods\u2002All 30 children older than one year by January 2017 who previously had fMMC repair at the Zurich Center for Fetal Diagnosis and Therapy were included. Sonographic evolution of fetal HC and Vp before and after fMMC repair was assessed and compared between the non-shunted (N\u200a=\u200a16) and the shunted group (N\u200a=\u200a14). ROC curves were generated for the fetal HC Z-score and Vp in order to show their predictive accuracy for the need for shunting until 1\u00a0year of age.<\/jats:p><jats:p>\n          Results\u2002HC was not an independent factor for predicting shunting. However, the need for shunting was directly dependent on the preoperative Vp as well as the Vp before delivery. A Vp\u200a&gt;\u200a10\u200amm at evaluation for fMMC repair or &gt;\u200a15\u200amm before delivery identifies 100\u200a% of the infants needing shunt placement at a false-positive rate of 44\u200a% and 25\u200a%, respectively. All fetuses with a Vp\u200a&gt;\u200a15\u200amm at first evaluation received a shunt.<\/jats:p><jats:p>\n          Conclusion\u2002Fetuses demonstrating a Vp of &gt;\u200a15\u200amm before in utero MMC repair are extremely likely to develop hydrocephalus requiring a shunt during the first year of life. This compelling piece of evidence must be appropriately integrated into prenatal counseling.<\/jats:p>","DOI":"10.1055\/a-0756-8417","type":"journal-article","created":{"date-parts":[[2018,10,22]],"date-time":"2018-10-22T23:01:06Z","timestamp":1540249266000},"page":"544-549","source":"Crossref","is-referenced-by-count":16,"title":["Prenatal Sonographic Head Circumference and Cerebral Ventricle Width Measurements Before and After Open Fetal Myelomeningocele Repair \u2013 Prediction of Shunting During the First Year of Life"],"prefix":"10.1055","volume":"41","author":[{"given":"Ladina","family":"Vonzun","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, University-Hospital Z\u00fcrich, Z\u00fcrich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franziska Maria","family":"Winder","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, University-Hospital Z\u00fcrich, Z\u00fcrich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Meuli","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery, University-Children\u2019s-Hospital Z\u00fcrich, Z\u00fcrich Center for Fetal Diagnosis and Therapy, Z\u00fcrich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ueli","family":"Moerlen","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery, University-Children\u2019s-Hospital Z\u00fcrich, Z\u00fcrich Center for Fetal Diagnosis and Therapy, Z\u00fcrich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Mazzone","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery, University-Children\u2019s-Hospital Z\u00fcrich, Z\u00fcrich Center for Fetal Diagnosis and Therapy, Z\u00fcrich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franziska","family":"Kraehenmann","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, University-Hospital Z\u00fcrich, Z\u00fcrich Center for Fetal Diagnosis and Therapy, Z\u00fcrich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margareth","family":"Huesler","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, University-Hospital Z\u00fcrich, Z\u00fcrich Center for Fetal Diagnosis and Therapy, Z\u00fcrich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roland","family":"Zimmermann","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, University-Hospital Z\u00fcrich, Z\u00fcrich Center for Fetal Diagnosis and Therapy, Z\u00fcrich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole","family":"Ochsenbein","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, University-Hospital Z\u00fcrich, Z\u00fcrich Center for Fetal Diagnosis and Therapy, Z\u00fcrich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2018,10,22]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1002\/pd.4524","article-title":"Cranial and cerebral signs in the diagnosis of spina bifida between 18 and 22 weeks of gestation: a German multicentre study","volume":"35","author":"F Bahlmann","year":"2015","journal-title":"Prenat Diagn"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1056\/NEJMoa1014379","article-title":"A randomized trial of prenatal versus postnatal repair of myelomeningocele","volume":"364","author":"N S Adzick","year":"2011","journal-title":"N Engl J 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