{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,6,22]],"date-time":"2022-06-22T23:14:54Z","timestamp":1655939694936},"reference-count":6,"publisher":"Georg Thieme Verlag KG","issue":"03","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aktuelle Urol"],"published-print":{"date-parts":[[2022,6]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title><jats:p>\n          Hintergrund\u2002Das Auftreten intravesikaler Condyolmata acuminata wird sporadisch in der Literatur beschrieben und gilt gemeinhin als benigne epitheliale Ver\u00e4nderung.<\/jats:p><jats:p>In nur sehr wenigen F\u00e4llen wurden invasive Karzinome als Folge eines anhaltenden Condylombefalls der Harnblase beschrieben.<\/jats:p><jats:p>\n          Fall\u2002Wir pr\u00e4sentieren den Fall eines 68-j\u00e4hrigen Patienten, der nach mehrj\u00e4hriger Anamnese gro\u00dffl\u00e4chiger intravesikaler Condylome ein muskelinvasives plattenepithelial-differenziertes Urothelkarzinom der Harnblase entwickelte. Nach mehrfacher TUR intravesikaler Condylome, ausgebliebener Instillationstherapie sowie vergessener Nachsorge \u00fcber Jahre wurde der Patient in unserer Klinik vorstellig. Nach Diagnosestellung einer Ichthyosis vesicae zeigte sich die Entwicklung eines plattenepithelial differenzierten, muskelinvasiven Urothelkarzinoms binnen nur 3 Monaten. Es erfolgte die radikale Zystektomie mit histologischer Beschreibung eines weiteren Tumorprogresses.<\/jats:p><jats:p>\n          Zusammenfassung\u2002Die karzinogene Potenz verschiedener HPV-Genomtypen ist bekannt und so sind v.\u200aa. Karzinome des weiblichen und m\u00e4nnlichen Genitales mit einer HPV-Infektion assoziiert. Intravesikale Condylome sind selten, werden in aller Regel als benigne L\u00e4sionen eingestuft und entsprechend zur\u00fcckhaltend behandelt. Unser Fall mit Entwicklung eines muskelinvasiven plattenepithelial differenzierten Karzinoms binnen weniger Monate zeigt jedoch die aggressive Potenz dieser Krankheit.<\/jats:p><jats:p>\n          Schlussfolgerung\u2002Die Diagnosestellung intravesikaler Condylome bedarf einer engmaschigen fachurologischen Nachsorge einschlie\u00dflich nachfolgender bioptischer Befundkontrollen sowie einer stadienadaptierten, im Zweifel radikalen Therapie bei etwaiger Karzinomentstehung. <\/jats:p>","DOI":"10.1055\/a-0761-2593","type":"journal-article","created":{"date-parts":[[2020,1,16]],"date-time":"2020-01-16T00:31:05Z","timestamp":1579134665000},"page":"275-278","source":"Crossref","is-referenced-by-count":0,"title":["Entwicklung eines plattenepithelial-differenzierten Harnblasenkarzinoms bei unbehandelten Condylomen der Harnblase"],"prefix":"10.1055","volume":"53","author":[{"given":"Jannika","family":"Heinzmann","sequence":"additional","affiliation":[{"name":"Main-Kinzig-Kliniken Standort Gelnhausen, Urologie, Gelnhausen"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"Schneider","sequence":"additional","affiliation":[{"name":"Main-Kinzig-Kliniken Standort Gelnhausen, Urologie, Gelnhausen"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marc-Oliver","family":"Riener","sequence":"additional","affiliation":[{"name":"MVZ OptiPath, Pathologie, Frankfurt am Main"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2022,6,7]]},"reference":[{"key":"ref1","first-page":"17","article-title":"Squamous change in bladder cancer and its relevance to understanding clonal evolution in development of bladder cancer","volume":"31","author":"S Baithun","year":"1998","journal-title":"Cancer Surv"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"e93525","DOI":"10.1371\/journal.pone.0093525","article-title":"Detection of human papillomavirus infection and p16 immunohistochemistry expression in bladder cancer with squamous differentiation","volume":"9","author":"S H Kim","year":"2014","journal-title":"PLoS One"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1002\/ijc.21892","article-title":"Cancer risk among patients with condylomata acuminata","volume":"119","author":"C Nordenvall","year":"2006","journal-title":"Int J Cancer"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.eucr.2016.04.016","article-title":"Progression of Intravesical Condyloma Acuminata to Locally Advanced Poorly Differentiated Squamous Cell Carcinoma","volume":"7","author":"A Khambati","year":"2016","journal-title":"Urol Case Rep"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"1534","DOI":"10.1038\/modpathol.2012.112","article-title":"Urothelial carcinoma with prominent squamous differentiation in the setting of neurogenic bladder: role of human papillomavirus infection","volume":"25","author":"E B Blochin","year":"2012","journal-title":"Mod Pathol"},{"key":"ref6","first-page":"232","article-title":"Role of human papillomavirus types 16, 18, and 52 in recurrent cystitis and urinary bladder cancer among Egyptian patients","volume":"10","author":"H Badawi","year":"2008","journal-title":"Medscape J Med"}],"container-title":["Aktuelle Urologie"],"original-title":[],"language":"de","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-0761-2593.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,6,22]],"date-time":"2022-06-22T22:47:56Z","timestamp":1655938076000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-0761-2593"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6]]},"references-count":6,"journal-issue":{"issue":"03","published-online":{"date-parts":[[2022,6,7]]},"published-print":{"date-parts":[[2022,6]]}},"URL":"https:\/\/doi.org\/10.1055\/a-0761-2593","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0001-7868","1438-8820"],"issn-type":[{"value":"0001-7868","type":"print"},{"value":"1438-8820","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,6]]}}}