{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T20:04:39Z","timestamp":1782331479986,"version":"3.54.5"},"reference-count":39,"publisher":"Georg Thieme Verlag KG","issue":"05","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ultraschall Med"],"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Purpose\u2002To assess the intrauterine course, associated conditions and postnatal outcome of fetuses with pulmonary atresia with ventricular septal defect (PAVSD).<\/jats:p><jats:p>Methods\u2002All cases of PAVSD diagnosed prenatally over a period of 10 years with a minimum follow-up of 6.5 years were retrospectively collected in 3 tertiary referral centers.<\/jats:p><jats:p>Results\u200250 cases of PAVSD were diagnosed prenatally. 44.0\u200a% of fetuses had isolated PAVSD, 4.0\u200a% had associated cardiac anomalies, 10.0\u200a% had extra-cardiac anomalies, 38.0\u200a% had chromosomal anomalies, 4.0\u200a% had non-chromosomal syndromes. Among the 32 liveborn children, 56.3\u200a% had reverse flow in the patent arterial duct, 25.0\u200a% had major aortopulmonary collateral arteries (MAPCAs) with ductal agenesis and 18.7\u200a% had a double supply. 17 pregnancies were terminated (34.0\u200a%), there was 1 intrauterine fetal death (2.0\u200a%), 1\u00a0neonatal death (2.0\u200a%), and 6 deaths (12.0\u200a%) in infancy. 25\u00a0of 30 (83.3\u200a%) liveborn children with an intention to treat were alive at the latest follow-up.\u200aThe mean follow-up among survivors was 10.0 years (range 6.5\u201315.1). 56.0\u200a% of infants underwent staged repair, 44.0\u200a% had one-stage complete repair. After exclusion of infants with additional chromosomal or syndromal anomalies, 88.9\u200a% were healthy, and 11.1\u200a% had mild limitations. The presence of MAPCAs did not differ significantly between survivors and non-survivors (p\u200a=\u200a0.360), between one-stage or staged repair (p\u200a=\u200a0.656) and healthy and impaired infants (p\u200a=\u200a0.319).<\/jats:p><jats:p>Conclusion\u2002The prognosis in cases without chromosomal or syndromal anomalies is good. MAPCAs did not influence prognosis or postoperative health. The incidence of repeat interventions due to recurrent stenoses is significantly higher after staged compared with single-stage repair.<\/jats:p>","DOI":"10.1055\/a-0770-2832","type":"journal-article","created":{"date-parts":[[2019,1,18]],"date-time":"2019-01-18T08:48:13Z","timestamp":1547801293000},"page":"514-525","source":"Crossref","is-referenced-by-count":7,"title":["Prenatal Diagnosis and Postnatal Outcome of Fetuses with Pulmonary Atresia and Ventricular Septal Defect"],"prefix":"10.1055","volume":"41","author":[{"given":"Ingo","family":"Gottschalk","sequence":"additional","affiliation":[{"name":"Division of Prenatal Medicine, University-Hospital of Cologne, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brigitte","family":"Strizek","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Prenatal Medicine, University-Hospital of Bonn, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christel","family":"Jehle","sequence":"additional","affiliation":[{"name":"Division of Prenatal Medicine, University-Hospital of Cologne, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R\u00fcdiger","family":"Stressig","sequence":"additional","affiliation":[{"name":"Praenatal.plus Prenatal Medicine and Genetics, praenatal.plus Cologne, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrike","family":"Herberg","sequence":"additional","affiliation":[{"name":"Department of Pediatric Cardiology, University-Hospital of Bonn, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes","family":"Breuer","sequence":"additional","affiliation":[{"name":"Department of Pediatric Cardiology, University-Hospital of Bonn, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konrad","family":"Brockmeier","sequence":"additional","affiliation":[{"name":"Department of Pediatric Cardiology, University-Hospital of Cologne, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Astrid","family":"Hellmund","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Prenatal Medicine, University-Hospital of Bonn, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annegret","family":"Geipel","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Prenatal Medicine, University-Hospital of Bonn, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrich","family":"Gembruch","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Prenatal Medicine, University-Hospital of Bonn, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Berg","sequence":"additional","affiliation":[{"name":"Division of Prenatal Medicine, University-Hospital of Cologne, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2019,1,7]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1016\/S0735-1097(85)80223-0","article-title":"Pulmonary blood supply in patients with pulmonary atresia and ventricular septal defect","volume":"6","author":"P K Liao","year":"1985","journal-title":"J Am Coll Cardiol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/0002-9149(89)91104-1","article-title":"Fistulous communications between a solitary coronary artery and the pulmonary arteries as the primary source of pulmonary blood supply in tetralogy of fallot with pulmonary valve atresia","volume":"63","author":"E 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