{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,15]],"date-time":"2026-03-15T05:09:33Z","timestamp":1773551373341,"version":"3.50.1"},"reference-count":0,"publisher":"Georg Thieme Verlag KG","issue":"04","funder":[{"name":"Scientific Research project supported by Huashan Hospital, Fudan University","award":["2016QD080"],"award-info":[{"award-number":["2016QD080"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Exp Clin Endocrinol Diabetes"],"published-print":{"date-parts":[[2020,4]]},"abstract":"Abstract<\/jats:title>\n Purpose We investigated the expression of vasopressin receptor 2 and\n 3 on corticotrophin tumor cells, their role in regulating ACTH secretion,\n and their potential therapeutic implications.<\/jats:p>\n Methods We retrospectively assessed 52 hospitalized patients with\n pathologically confirmed ACTH-secreting tumors. The expression of\n vasopressin receptor 2 and 3 was explored via qualitative and quantitative\n immunohistochemistry analyses. The role of vasopressin receptors in\n regulating ACTH secretion was further studied in the AtT-20 cell line.<\/jats:p>\n Results Among 50 cases of pituitary corticotrophin adenoma, 31 were\n vasopressin receptor 2 positive, 38 were vasopressin receptor 3 positive,\n and 24 were both vasopressin receptor 2 and 3 positive. Two patients with\n ectopic ACTH syndrome were vasopressin receptor 3 positive, and one was also\n vasopressin receptor 2 positive. In 12 patients who underwent bilateral\n inferior petrosal sinus sampling before surgery, the central ACTH increment\n ratio after desmopressin stimulation was correlated with vasopressin\n receptor 2 but not with vasopressin receptor 3 staining intensity. In an in\n vitro study, the expression of both vasopressin receptor 2 and 3 on AtT-20\n cells was confirmed. The vasopressin receptor 2 antagonist Tolvaptan\n inhibited desmopressin-induced ACTH secretion in a dose-dependent\n manner.<\/jats:p>\n Conclusions Both vasopressin receptor 2 and 3 are expressed in\n ACTH-secreting tumors. Vasopressin receptor 2 rather than vasopressin\n receptor 3 is the primary receptor that seems to mediate the ACTH response\n in corticotrophin tumors. A vasopressin receptor 2 antagonist can inhibit\n ACTH secretion induced by desmopressin in AtT-20 cells.<\/jats:p>","DOI":"10.1055\/a-0808-4227","type":"journal-article","created":{"date-parts":[[2019,1,23]],"date-time":"2019-01-23T01:06:41Z","timestamp":1548205601000},"page":"263-269","source":"Crossref","is-referenced-by-count":4,"title":["Role of Vasopressin Receptor 2 and 3 in ACTH-Secreting Tumors and\n their Potential Therapeutic Implications"],"prefix":"10.1055","volume":"128","author":[{"given":"Jia","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, Huashan Hospital, Shanghai\n Medical College, Fudan University, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yehong","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, Huashan Hospital, Shanghai\n Medical College, Fudan University, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yongfei","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Huashan Hospital, Shanghai Medical College,\n Fudan University, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuo","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, Huashan Hospital, Shanghai\n Medical College, Fudan University, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haixia","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Neuropathology, Huashan Hospital, Shanghai Medical\n College, Fudan University, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuyang","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pathology, Shanghai Medical College, Fudan University,\n Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liang","family":"Ge","sequence":"additional","affiliation":[{"name":"Department of Interventional Radiology, Huashan Hospital, Shanghai\n Medical College, Fudan University, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yiming","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, Huashan Hospital, Shanghai\n Medical College, Fudan University, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongying","family":"Ye","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, Huashan Hospital, Shanghai\n Medical College, Fudan University, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2019,1,22]]},"container-title":["Experimental and Clinical Endocrinology & Diabetes"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-0808-4227.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,4,6]],"date-time":"2020-04-06T22:37:19Z","timestamp":1586212639000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-0808-4227"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1,22]]},"references-count":0,"journal-issue":{"issue":"04","published-online":{"date-parts":[[2020,4,6]]},"published-print":{"date-parts":[[2020,4]]}},"URL":"https:\/\/doi.org\/10.1055\/a-0808-4227","relation":{},"ISSN":["0947-7349","1439-3646"],"issn-type":[{"value":"0947-7349","type":"print"},{"value":"1439-3646","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,1,22]]}}}