{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,4,4]],"date-time":"2022-04-04T02:05:14Z","timestamp":1649037914584},"reference-count":0,"publisher":"Georg Thieme Verlag KG","issue":"01","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nuklearmedizin"],"published-print":{"date-parts":[[2019,2]]},"abstract":"Abstract<\/jats:title>\n Aim The aim of this study was to establish normal values for parotid gland\n (PG) and submandibular-sublingual salivary gland complex (SSC) uptake of\n 99mtechnetium pertechnetate (99mTcO4) as a\n function of age, sex and circadian rhythm in mice.<\/jats:p>\n Methods In 12 female (F) and 12 male (M) C57BL\/6N mice, nine consecutive\n SPECT images of 10\u2005min each were acquired as dynamic acquisitions beginning\n 5\u2005min after intravenous injection of 80 MBq 99mTcO4. Each\n mouse was imaged in follow-up studies at 1, 3, 6, 12 and 24 months of age. In\n order to assess for physiologic changes related to circadian rhythm, animals\n were imaged during light (sleeping phase) as well as during night conditions\n (awake phase). The percentage tracer uptake of the injected activity is\n expressed as median %ID.<\/jats:p>\n Results Maximum 99mTcO4 uptake occurred earlier in\n PG at 11\u2005min compared to SSC at 79\u2005min (p\u2005<\u20050.001). No significant effect of\n circadian rhythm was observed in PG (p\u2005=\u20050.64) and SSC uptake (p\u2005=\u20050.27). With\n aging, 99mTcO4 uptake significantly decreased for PG\n (p\u2005<\u20050.001) while it increased for SSC (p\u2005<\u20050.001). F (0.5) had a\n significantly higher PG uptake than M (0.3; p\u2005<\u20050.001) up to an age of 24\n months. However, SSC uptake of F (4.6) was higher than that of M (3.8;\n p\u2005=\u20050.014) only at the age of 1 month. Thereafter, F (5.6) had lower SSC uptake\n than M (9.2; p\u2005<\u20050.001) from 3 months onwards. Normalizing %ID to gland\n volume showed that F had a significantly higher uptake (%ID\/mm3) in\n both PG (F 0.013; M 0.007; p\u2005<\u20050.001) and in SSC (F 0.110; M 0.075;\n p\u2005<\u20050.001).<\/jats:p>\n Conclusion Uptake patterns differed among PG and SSC with a significant\n impact of age and sex while circadian rhythm had no significant influence.\n Therefore, design of salivary gland studies in mice using\n 99mTcO4 should consider age and sex as relevant\n factors.<\/jats:p>","DOI":"10.1055\/a-0810-0174","type":"journal-article","created":{"date-parts":[[2019,2,15]],"date-time":"2019-02-15T23:54:18Z","timestamp":1550274858000},"page":"39-49","source":"Crossref","is-referenced-by-count":1,"title":["Normal Values for Parotid Gland and\n Submandibular-Sublingual Salivary Gland Complex Uptake of\n 99mTechnetium Pertechnetate using SPECT in Mice with Respect to Age,\n Sex, and Circadian Rhythm"],"prefix":"10.1055","volume":"58","author":[{"given":"Eleonore L.","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Charit\u00e9 \u2013 Universit\u00e4tsmedizin\n Berlin"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ingo G.","family":"Steffen","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Charit\u00e9 \u2013 Universit\u00e4tsmedizin\n Berlin"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mathias","family":"Lukas","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Charit\u00e9 \u2013 Universit\u00e4tsmedizin\n Berlin"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kai","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Charit\u00e9 \u2013 Universit\u00e4tsmedizin\n Berlin"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joerg R.","family":"Aschenbach","sequence":"additional","affiliation":[{"name":"Institute of Veterinary Physiology, Department of Veterinary Medicine,\n Freie Universit\u00e4t Berlin"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janet F.","family":"Eary","sequence":"additional","affiliation":[{"name":"US National Institutes of Health\/NCI\/DCTD"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Winfried","family":"Brenner","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Charit\u00e9 \u2013 Universit\u00e4tsmedizin\n Berlin"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicola","family":"Beindorff","sequence":"additional","affiliation":[{"name":"Berlin Experimental Radionuclide Imaging Center (BERIC), Charit\u00e9 \u2013\n Universit\u00e4tsmedizin Berlin"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2019,2,15]]},"container-title":["Nuklearmedizin"],"original-title":[],"language":"de","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-0810-0174.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,2,15]],"date-time":"2019-02-15T23:54:21Z","timestamp":1550274861000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-0810-0174"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,2]]},"references-count":0,"journal-issue":{"issue":"01","published-online":{"date-parts":[[2019,2,15]]},"published-print":{"date-parts":[[2019,2]]}},"URL":"https:\/\/doi.org\/10.1055\/a-0810-0174","relation":{},"ISSN":["0029-5566","2567-6407"],"issn-type":[{"value":"0029-5566","type":"print"},{"value":"2567-6407","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,2]]}}}