{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T01:08:24Z","timestamp":1787620104195,"version":"build-2736575974"},"reference-count":36,"publisher":"Georg Thieme Verlag KG","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Exp Clin Endocrinol Diabetes"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\nAims The aim of our study was to assess the effect of glycemic control on placental vascularization in pregnancies complicated by type 1 diabetes mellitus (T1DM) and to compare dataset of optimal\/suboptimal glycemic control to normal placental 3-dimensional power Doppler (3-DPD) indices in 2nd and 3rd trimester.<\/jats:p><jats:p>\nMethods Placental vascularization of pregnant women was prospectively evaluated by 3-DPD ((vascularization-index (VI); flow-index (FI); vascularization-flow-index (VFI)) ultrasound technique. The normal pregnancies (n=214) were compared to those complicated by T1DM (n=53) with optimal (HbA1C\u22646%;\u2264\u200942\u2009mmol\/mol) and suboptimal (HbA1C&gt;6%;&gt;42\u2009mmol\/mol) glycemic control.<\/jats:p><jats:p>\nResults Pregnancies complicated by T1DM expressed lower placental vascularization indices as compared with normal pregnancies (adjusted odds ratio (AOR) for VI:0.86; FI:0.94; VFI:0.76). Placental 3-DPD indices have a significant correlation with HbA1C and optimal glycemic control is associated with lower placental perfusion (AOR for VI:1.64; FI:1.13; VFI:2.34). Short-term adverse neonatal outcome was predicted by lower 3-DPD indices (AORVI:0.83, AORFI:0.93, AORVFI:0.66, p&lt;0.05 for each index). Besides the glycemic control, the pregestational body mass index (BMI), had significant influences on placental perfusion.<\/jats:p><jats:p>\nConclusions VI displayed the best screening ability for suboptimal glycemic control with a sensitivity of 90.9%. The suboptimal glycemic control has a direct deteriorating effect on placental vasculature. Therefore the ultrasound examination could be an adjunct diagnostic modality for pregnant women with T1DM.<\/jats:p>","DOI":"10.1055\/a-0824-6362","type":"journal-article","created":{"date-parts":[[2019,1,18]],"date-time":"2019-01-18T10:20:36Z","timestamp":1547806836000},"page":"788-795","source":"Crossref","is-referenced-by-count":4,"title":["Ultrasonographic Evaluation of Glycemic Control Effect on Placental Vascularization in Pregnancy with Type 1 Diabetes Mellitus"],"prefix":"10.1055","volume":"128","author":[{"given":"Zoltan","family":"Kozinszky","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Blekinge Hospital, Karlskrona, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"AbelT.","family":"Altorjay","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, University of Szeged, Szeged, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andras","family":"Molnar","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, University of Szeged, Szeged, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tibor","family":"Ny\u00e1ri","sequence":"additional","affiliation":[{"name":"Department of Medical Physics and Informatics, University of Szeged, Szeged, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandor G.","family":"Vari","sequence":"additional","affiliation":[{"name":"International Research and Innovation in Medicine Program, Cedars - Sinai Medical Center, Los Angeles, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabor","family":"Nemeth","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, University of Szeged, Szeged, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Suranyi","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, University of Szeged, Szeged, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2019,1,14]]},"reference":[{"key":"ref2","first-page":"CD008540","article-title":"Different intensities of glycaemic control for pregnant women with pre-existing diabetes","volume":"8","author":"P Middleton","year":"2012","journal-title":"Cochrane Database Syst Rev"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"149","DOI":"10.3109\/14767058.2013.806896","article-title":"Poor pregnancy outcome in women with type 1 diabetes is predicted by elevated HbA1c and spikes of high glucose values in the third trimester","volume":"27","author":"P Damm","year":"2014","journal-title":"J Matern Fetal Neonatal Med"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1007\/s005920050077","article-title":"Glycosylated hemoglobin as predictor of adverse foetal outcome in type 1 diabetic pregnancies","volume":"34","author":"G L Nielsen","year":"1997","journal-title":"Acta Diabetol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1001\/jama.1991.03460060063025","article-title":"Preconception care of diabetes. 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