{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T23:08:56Z","timestamp":1778281736752,"version":"3.51.4"},"reference-count":0,"publisher":"Georg Thieme Verlag KG","issue":"02","funder":[{"DOI":"10.13039\/501100001809","name":"National Nature Science Foundation of China","doi-asserted-by":"crossref","award":["81670758 to L.P. and 81370918 to X.M."],"award-info":[{"award-number":["81670758 to L.P. and 81370918 to X.M."]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Beijing Municipal Natural Science Foundation of China","award":["7182147 to L.P."],"award-info":[{"award-number":["7182147 to L.P."]}]},{"name":"Capital\u2019s Funds for Health Improvement and Research","award":["2018\u20132\u20134062 to L.P."],"award-info":[{"award-number":["2018\u20132\u20134062 to L.P."]}]},{"name":"Young medical talents award program of Chinese academy of medicine","award":["2018RC310023"],"award-info":[{"award-number":["2018RC310023"]}]},{"name":"Nature Science Foundation of Jilin Province","award":["20180101113JC to H.C."],"award-info":[{"award-number":["20180101113JC to H.C."]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Exp Clin Endocrinol Diabetes"],"published-print":{"date-parts":[[2020,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Demyelination resulting from Schwann cell injury is a main pathological feature of diabetic neuropathy, and a key contributor to this process may be inflammation due to advanced glycation end products (AGEs). Therefore, protection by anti-inflammation agents is anticipated. In this study, we showed that interleukin-10 (IL-10), an anti-inflammatory cytokine, inhibits apoptosis of Schwann cells induced by AGEs in vitro. We isolated and cultured Schwann cells from rat sciatic nerves. As detected by flow cytometry, apoptosis of Schwann cells markedly increased following incubation with AGEs for 48\u2009h. However, pretreatment with IL-10 inhibited AGE-induced apoptosis. The effect of IL-10 on NF-\u03baB, which is a very important regulator of inflammation, was also evaluated, and results showed high levels of phospho-NF-\u03baB and nuclear localization of NF-\u03baB in cells incubated with AGEs but low levels of phospho-NF-\u03baB and cytoplasmic localization in the cells incubated with IL-10, indicating the activation of NF-\u03baB by AGEs and inhibition of NF-\u03baB by IL-10. Moreover, incubating Schwann cells with an NF-\u03baB inhibitor (caffeic acid phenethyl ester) for 30\u2009min before adding AGEs mimicked IL-10, lowering the amount of reactive oxygen species and activity of caspase-3 and also decreasing apoptosis in Schwann cells. These results indicate that IL-10 may protect Schwann cells against AGE-induced apoptosis by attenuating oxidative stress via the inhibition of activation of NF-\u03baB.<\/jats:p>","DOI":"10.1055\/a-0826-4374","type":"journal-article","created":{"date-parts":[[2019,1,18]],"date-time":"2019-01-18T05:20:36Z","timestamp":1547788836000},"page":"89-96","source":"Crossref","is-referenced-by-count":13,"title":["Interleukin-10 Protects Schwann Cells against Advanced Glycation End Products-Induced Apoptosis via NF-\u03baB Suppression"],"prefix":"10.1055","volume":"128","author":[{"given":"Shiqing","family":"Xu","sequence":"additional","affiliation":[{"name":"Institute of Clinical Medical Sciences, China-Japan Friendship Hospital, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weijie","family":"Bao","sequence":"additional","affiliation":[{"name":"The People\u2019s Hospital of He Bi, Hebi, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiuli","family":"Men","sequence":"additional","affiliation":[{"name":"Department of Pathophysiology, North China University of Science and Technology, Tangshan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Gynecology & Obstetrics, China-Japan Friendship Hospital, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Gynecology & Obstetrics, China-Japan Friendship Hospital, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Stomatology, China-Japan Friendship Hospital, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Honglin","family":"Liu","sequence":"additional","affiliation":[{"name":"Institute of Clinical Medical Sciences, China-Japan Friendship Hospital, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hanqing","family":"Cai","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, The Second Hospital of Jilin University, Changchun, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenjian","family":"Zhang","sequence":"additional","affiliation":[{"name":"Suzhou Rely Bio-Tech Co., Ltd. Suzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinning","family":"Lou","sequence":"additional","affiliation":[{"name":"Suzhou Rely Bio-Tech Co., Ltd. Suzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liang","family":"Peng","sequence":"additional","affiliation":[{"name":"Institute of Clinical Medical Sciences, China-Japan Friendship Hospital, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2019,1,14]]},"container-title":["Experimental and Clinical Endocrinology &amp; Diabetes"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-0826-4374.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,1,31]],"date-time":"2020-01-31T19:41:15Z","timestamp":1580499675000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-0826-4374"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1,14]]},"references-count":0,"journal-issue":{"issue":"02","published-online":{"date-parts":[[2020,1,31]]},"published-print":{"date-parts":[[2020,2]]}},"URL":"https:\/\/doi.org\/10.1055\/a-0826-4374","relation":{},"ISSN":["0947-7349","1439-3646"],"issn-type":[{"value":"0947-7349","type":"print"},{"value":"1439-3646","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,1,14]]}}}