{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T17:45:52Z","timestamp":1784051152427,"version":"3.55.0"},"reference-count":49,"publisher":"Georg Thieme Verlag KG","issue":"02","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Exp Clin Endocrinol Diabetes"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\nIntroduction The HbA1c has been considered as the \u2018gold standard\u2019 in diabetes diagnosis and management, however, age, gender and body mass index (BMI) might have certain effects on HbA1c. We are aiming to further investigate the correlation between age and HbA1c, and whether it was affected by gender and BMI.<\/jats:p><jats:p>\nMethods A cross-sectional survey including 135,893 nondiabetic individuals who took the physical examination between 2013 and 2017 was conducted. The subjects were grouped by gender, age and BMI, and the interactive and independent effects of the 3 factors on the HbA1c were detected. The median and 95% confidence interval (CI) of HbA1c levels were calculated.<\/jats:p><jats:p>\nResults The HbA1c levels gradually increased along with age, both in female and male, and there is a positive association between BMI and the HbA1c. The difference on HbA1c in gender was associated with both age and BMI, the age-related increase in HbAlc was accentuated in the subgroup with higher BMI, and there was a marked accentuation of the positive association between BMI and HbA1c as age increased. In almost all the young and middle-aged (aged 20\u201359) subgroups, the 97.5th percentiles of HbA1c levels were lower than 6.5%, suggesting that the single HbA1c cutoff value is probably not applicable to the young and middle-aged population.<\/jats:p><jats:p>\nConclusions We recommend that the effects of age, gender and BMI should be taken into consideration when using HbA1c for the diagnosis and management of diabetes, especially in the young and middle-aged population.<\/jats:p>","DOI":"10.1055\/a-0833-8119","type":"journal-article","created":{"date-parts":[[2019,4,30]],"date-time":"2019-04-30T19:57:27Z","timestamp":1556654247000},"page":"86-92","source":"Crossref","is-referenced-by-count":15,"title":["Reconsidering the HbA1c Cutoff for Diabetes Diagnosis Based on a Large Chinese Cohort"],"prefix":"10.1055","volume":"129","author":[{"given":"Jiying","family":"Qi","sequence":"additional","affiliation":[{"name":"Shanghai Clinical Center for Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Su","sequence":"additional","affiliation":[{"name":"Clinical Laboratory, Sichuan Academy of Medical Science & Sichuan Provincial People\u2019s Hospital, Chengdu, China"},{"name":"Chinese Academy of Sciences, Sichuan Translational Medicine Research Hospital, Chengdu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qianqian","family":"Song","sequence":"additional","affiliation":[{"name":"Shanghai Clinical Center for Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaojun","family":"Ding","sequence":"additional","affiliation":[{"name":"Shanghai Clinical Center for Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Cao","sequence":"additional","affiliation":[{"name":"Shanghai Clinical Center for Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Cui","sequence":"additional","affiliation":[{"name":"Shanghai Clinical Center for Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Qi","sequence":"additional","affiliation":[{"name":"Department of Endocrine and Metabolic Diseases, Ruijin Hospital North, Shanghai JiaoTong University School of Medicine, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2019,4,30]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.diabres.2009.10.007","article-title":"Global estimates of the prevalence of diabetes for 2010 and 2030","volume":"87","author":"J E Shaw","year":"2010","journal-title":"Diabetes Res Clin Pract"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"2515","DOI":"10.1001\/jama.2017.7596","article-title":"Prevalence and ethnic pattern of diabetes and prediabetes in China in 2013","volume":"317","author":"L Wang","year":"2017","journal-title":"JAMA"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"2617","DOI":"10.1021\/ja01540a030","article-title":"Observations on the chromatographic heterogeneity of normal adult and fetal human hemoglobin: a study of the effects of 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