{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T06:24:33Z","timestamp":1768285473954,"version":"3.49.0"},"reference-count":0,"publisher":"Georg Thieme Verlag KG","issue":"02","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Klin Padiatr"],"published-print":{"date-parts":[[2019,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\nBackground Hyperammonemic encephalopathy in newborns with urea cycle disorders and certain organic acidurias can cause severe brain injury, coma and death. Standard therapy includes protein restriction, nitrogen-scavenging drugs, prevention of catabolism and hemodialysis. Neuroprotective hypothermia as part of the treatment has been reported only 3 times. It has been suggested that mild systemic hypothermia can contribute to better neurological outcomes in hyperammonemic encephalopathy. However, the limited experience precludes accurate conclusions on safety and efficacy.<\/jats:p><jats:p>\nMethods Whole body therapeutic hypothermia was included in the standard treatment of hyperammonemic encephalopathy in 4 neonates with urea cycle disorder or organic aciduria.<\/jats:p><jats:p>\nResults Two patients survived the initial crisis. One patient has a developmental quotient of 0.8, while the other shows severe developmental delay. The cooling protocol had to be discontinued in 3 patients due to the otherwise untreatable complications (hypotension and hemorrhage).<\/jats:p><jats:p>\nConclusion The efficacy and safety of therapeutic hypothermia in the treatment of neonatal hyperammonemic encephalopathy depend on various factors, requiring further evaluation.<\/jats:p>","DOI":"10.1055\/a-0855-4001","type":"journal-article","created":{"date-parts":[[2019,3,14]],"date-time":"2019-03-14T23:42:49Z","timestamp":1552606969000},"page":"74-79","source":"Crossref","is-referenced-by-count":6,"title":["The Therapeutic Hypothermia in Treatment of Hyperammonemic Encephalopathy due to Urea Cycle Disorders and Organic Acidemias"],"prefix":"10.1055","volume":"231","author":[{"given":"Dorotea","family":"Ninkovi\u0107","sequence":"additional","affiliation":[{"name":"Klinika za pedijatriju, Sveuciliste u Zagrebu Medicinski fakultet, Zagreb, Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u017deljka","family":"Mustapi\u0107","sequence":"additional","affiliation":[{"name":"Klinika za pedijatriju, Klinicki Bolnicki Centar Zagreb, Zagreb, Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dorotea","family":"Bartoni\u010dek","sequence":"additional","affiliation":[{"name":"Klinika za pedijatriju, Klinicki Bolnicki Centar Zagreb, Zagreb, Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vesna","family":"Benjak","sequence":"additional","affiliation":[{"name":"Klinika za pedijatriju, Klinicki Bolnicki Centar Zagreb, Zagreb, Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mario","family":"\u0106uk","sequence":"additional","affiliation":[{"name":"Klinika za pedijatriju, Sveuciliste u Zagrebu Medicinski fakultet, Zagreb, Croatia"},{"name":"Klinika za pedijatriju, Klinicki Bolnicki Centar Zagreb, Zagreb, Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Buljevi\u0107","sequence":"additional","affiliation":[{"name":"Klinika za pedijatriju, Klinicki Bolnicki Centar Zagreb, Zagreb, Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Boris","family":"Gr\u010di\u0107","sequence":"additional","affiliation":[{"name":"Klinika za pedijatriju, Sveuciliste u Zagrebu Medicinski fakultet, Zagreb, Croatia"},{"name":"Klinika za pedijatriju, Klinicki Bolnicki Centar Zagreb, Zagreb, Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ksenija","family":"Fumi\u0107","sequence":"additional","affiliation":[{"name":"Klinika za laboratorijsku dijagnostiku, Klinicki Bolnicki Centar Zagreb, Zagreb, Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ru\u017ea","family":"Grizelj","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University Hospital Centre Zagreb, Univeristy of Zagreb Medical School, Zagreb, Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ivan","family":"Lehman","sequence":"additional","affiliation":[{"name":"Klinika za pedijatriju, Klinicki Bolnicki Centar Zagreb, Zagreb, Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Danijela","family":"Ramad\u017ea","sequence":"additional","affiliation":[{"name":"Klinika za pedijatriju, Sveuciliste u Zagrebu Medicinski fakultet, Zagreb, Croatia"},{"name":"Klinika za pedijatriju, Klinicki Bolnicki Centar Zagreb, Zagreb, Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vladimir","family":"Sarnavka","sequence":"additional","affiliation":[{"name":"Klinika za pedijatriju, Klinicki Bolnicki Centar Zagreb, Zagreb, Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jasna","family":"Slavi\u010dek","sequence":"additional","affiliation":[{"name":"Klinika za pedijatriju, Klinicki Bolnicki Centar Zagreb, Zagreb, Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jasminka","family":"Kasteli\u0107","sequence":"additional","affiliation":[{"name":"Klinika za pedijatriju, Klinicki Bolnicki Centar Zagreb, Zagreb, Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nina","family":"Bari\u0161i\u0107","sequence":"additional","affiliation":[{"name":"Klinika za pedijatriju, Sveuciliste u Zagrebu Medicinski fakultet, Zagreb, Croatia"},{"name":"Klinika za pedijatriju, Klinicki Bolnicki Centar Zagreb, Zagreb, Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ivo","family":"Bari\u0107","sequence":"additional","affiliation":[{"name":"Klinika za pedijatriju, Sveuciliste u Zagrebu Medicinski fakultet, Zagreb, Croatia"},{"name":"Klinika za pedijatriju, Klinicki Bolnicki Centar Zagreb, Zagreb, Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2019,3,14]]},"container-title":["Klinische P\u00e4diatrie"],"original-title":[],"language":"de","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-0855-4001.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,3,14]],"date-time":"2019-03-14T23:42:50Z","timestamp":1552606970000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-0855-4001"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,3]]},"references-count":0,"journal-issue":{"issue":"02","published-online":{"date-parts":[[2019,3,14]]},"published-print":{"date-parts":[[2019,3]]}},"URL":"https:\/\/doi.org\/10.1055\/a-0855-4001","relation":{},"ISSN":["0300-8630","1439-3824"],"issn-type":[{"value":"0300-8630","type":"print"},{"value":"1439-3824","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,3]]}}}