{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,4,5]],"date-time":"2022-04-05T10:27:06Z","timestamp":1649154426560},"reference-count":0,"publisher":"Georg Thieme Verlag KG","issue":"02","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nuklearmedizin"],"published-print":{"date-parts":[[2019,4]]},"abstract":"Abstract<\/jats:title>\n Aim Retrospective evaluation of serial FDG-PET\/CT scans in head and neck\n squamous cell cancer (HNSCC) patient\u2019s follow-up after primary radiochemotherapy\n (RCTx), to assess the diagnostic accuracy of an experienced observer vs. an\n objective classification compared to standard clinical follow-up\n examinations.<\/jats:p>\n Methods Sixty-nine patients with locally advanced HNSCC were included, who\n received curative RCTx. Follow-up included serial FDG-PET\/CT at the following\n time intervals t1:\u2005\u2264\u2005270 d, t2: 271\u2013540 d, t3:\u2005>\u2005540 d after curative RCTx.\n The likelihood to detect local recurrences, nodal and distant metastases were\n compared between (i) experienced observer, (ii) an objective classification\n system by Zundel et al. 25, and (iii) routine\n clinical follow-up examinations.<\/jats:p>\n Results Twenty-two local recurrences, 7 nodal and 17 distant metastases\n were recorded during the follow-up. The diagnostic accuracy for local recurrence\n of the experienced observer vs. objective classification was 78 % vs. 77 % for\n t1, 83 % vs. 79 % for t2 and 100\u2005% vs. 84 % for t3.<\/jats:p>The classification (ii) and the conventional follow-up (iii) resulted in a\n relatively high amount of equivocal findings reducing the diagnostic\n accuracy.<\/jats:p>\n Conclusion Evaluation of FDG-PET\/CT by an experienced observer in\n follow-up of HNSCC patients after curative RCTx resulted in the highest\n diagnostic accuracy in comparison to an objective classification and to routine\n clinical examination.<\/jats:p>HNSCC is a malignant tumor with a high likelihood of recurrence, especially in\n the first two years after curative RCTx. Early detection of recurrence is of\n high clinical importance, since there are several effective second line\n therapies that may have curative potential in some patients.<\/jats:p>","DOI":"10.1055\/a-0859-6518","type":"journal-article","created":{"date-parts":[[2019,3,27]],"date-time":"2019-03-27T19:34:16Z","timestamp":1553715256000},"page":"93-100","source":"Crossref","is-referenced-by-count":2,"title":["Comparison of subjective evaluation versus objective\n algorithm in the interpretation of follow-up FDG-PET\/CT scans after\n radiochemotherapy in head and neck cancer patients"],"prefix":"10.1055","volume":"58","author":[{"given":"Alexander","family":"Kohler","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Faculty of Medicine and University\n Hospital Carl Gustav Carus, Technische Universit\u00e4t Dresden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steffen","family":"L\u00f6ck","sequence":"additional","affiliation":[{"name":"Department of Radiotherapy and Radiation Oncology, Faculty of Medicine\n and University Hospital Carl Gustav Carus, Technische Universit\u00e4t\n Dresden"},{"name":"National Center for Tumor Diseases (NCT), Partner Site Dresden,\n Germany: German Cancer Research Center (DKFZ), Heidelberg, Germany; Faculty of\n Medicine and University Hospital Carl Gustav Carus, Technische Universit\u00e4t\n Dresden, Dresden, Germany, and; Helmholtz Association\/Helmholtz-Zentrum\n Dresden-Rossendorf (HZDR)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steffen","family":"Appold","sequence":"additional","affiliation":[{"name":"Department of Radiotherapy and Radiation Oncology, Faculty of Medicine\n and University Hospital Carl Gustav Carus, Technische Universit\u00e4t\n Dresden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Bandurska-Luque","sequence":"additional","affiliation":[{"name":"Department of Radiotherapy and Radiation Oncology, Faculty of Medicine\n and University Hospital Carl Gustav Carus, Technische Universit\u00e4t\n Dresden"},{"name":"National Center for Tumor Diseases (NCT), Partner Site Dresden,\n Germany: German Cancer Research Center (DKFZ), Heidelberg, Germany; Faculty of\n Medicine and University Hospital Carl Gustav Carus, Technische Universit\u00e4t\n Dresden, Dresden, Germany, and; Helmholtz Association\/Helmholtz-Zentrum\n Dresden-Rossendorf (HZDR)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sebastian","family":"Hober\u00fcck","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Faculty of Medicine and University\n Hospital Carl Gustav Carus, Technische Universit\u00e4t Dresden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"Schreiber","sequence":"additional","affiliation":[{"name":"Department of Radiotherapy, Hospital\n Dresden-Friedrichstadt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00f6rg","family":"Kotzerke","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Faculty of Medicine and University\n Hospital Carl Gustav Carus, Technische Universit\u00e4t Dresden"},{"name":"National Center for Tumor Diseases (NCT), Partner Site Dresden,\n Germany: German Cancer Research Center (DKFZ), Heidelberg, Germany; Faculty of\n Medicine and University Hospital Carl Gustav Carus, Technische Universit\u00e4t\n Dresden, Dresden, Germany, and; Helmholtz Association\/Helmholtz-Zentrum\n Dresden-Rossendorf (HZDR)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Zips","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, University Hospital and Medical\n Faculty, Eberhard-Karls-Universit\u00e4t T\u00fcbingen"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Klaus","family":"Z\u00f6phel","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Faculty of Medicine and University\n Hospital Carl Gustav Carus, Technische Universit\u00e4t Dresden"},{"name":"National Center for Tumor Diseases (NCT), Partner Site Dresden,\n Germany: German Cancer Research Center (DKFZ), Heidelberg, Germany; Faculty of\n Medicine and University Hospital Carl Gustav Carus, Technische Universit\u00e4t\n Dresden, Dresden, Germany, and; Helmholtz Association\/Helmholtz-Zentrum\n Dresden-Rossendorf (HZDR)"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2019,3,27]]},"container-title":["Nuklearmedizin"],"original-title":[],"language":"de","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-0859-6518.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T08:34:54Z","timestamp":1554107694000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-0859-6518"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,3,27]]},"references-count":0,"journal-issue":{"issue":"02","published-online":{"date-parts":[[2019,3,27]]},"published-print":{"date-parts":[[2019,3]]}},"URL":"https:\/\/doi.org\/10.1055\/a-0859-6518","relation":{},"ISSN":["0029-5566","2567-6407"],"issn-type":[{"value":"0029-5566","type":"print"},{"value":"2567-6407","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,3,27]]}}}