{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T10:40:38Z","timestamp":1778755238267,"version":"3.51.4"},"reference-count":0,"publisher":"Georg Thieme Verlag KG","issue":"06","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Laryngo-Rhino-Otol"],"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title><jats:p>Hypersalivation bezeichnet einen \u00fcberm\u00e4\u00dfigen Speichelfluss, der durch\n                    insuffiziente orofaziale F\u00e4higkeiten, verminderte zentralnerv\u00f6se Kontrolle und\n                    Koordination oder gest\u00f6rte Schluckabl\u00e4ufe entstehen kann. Die Aktualisierung der\n                    S2k-Leitlinie soll den neuen diagnostischen und therapeutischen Kenntnisstand\n                    ber\u00fccksichtigen.<\/jats:p><jats:p>Die Diagnostik- und Therapiema\u00dfnahmen sollten multidisziplin\u00e4r erfolgen.\n                    Schwerpunkte sind die Abkl\u00e4rung von Schluckst\u00f6rungen mit Speichelaspiration.\n                    Hier sind klinische Screeninguntersuchungen und die fiberendoskopische\n                    Schluckuntersuchung (FEES) hervorzuheben.<\/jats:p><jats:p>Bei fast allen Ursachen sind die schlucktherapeutischen \u00dcbungsma\u00dfnahmen zur\n                    Aktivierung und zum Erlernen von Kompensationsmechanismen unverzichtbar.\n                    Insbesondere bei Kindern mit hypotoner orofazialer Muskulatur sind\n                    myofunktionelle Therapiekonzepte indiziert, allerdings ist die Kompetenz zur\n                    Mitarbeit entscheidend. Zus\u00e4tzlich k\u00f6nnen orale Stimulationsplatten durch die\n                    Ver\u00e4nderung der Zungenpositionierung zu einer Symptomreduktion f\u00fchren. Sinnvolle\n                    medikament\u00f6se Therapien sind insbesondere die verschiedenen Applikationsformen\n                    von Glycopyrrolat, von denen Sialanar\u00ae (Glycopyrronium) als Saft eine\n                    Genehmigung zur Behandlung bei Kindern ab 3 Jahren und Jugendlichen erhalten\n                    hat. Die Injektion von Botulinumtoxin in die Kopfspeicheldr\u00fcsen hat sich als\n                    effektive und sichere Behandlungsform mit einer langanhaltenden\n                    Speichelreduktion erwiesen. F\u00fcr Incobotulinumtoxin A ist die Phase III-Studie\n                    bei Erwachsenen aktuell abgeschlossen und f\u00fchrte in den USA bereits zur\n                    Zulassungserweiterung bei Hypersalivation. Chirurgische Eingriffe der\n                    Speicheldr\u00fcsen bleiben Einzelf\u00e4llen vorbehalten. Die Bestrahlung der\n                    Speicheldr\u00fcsen ist, insbesondere wenn sie in moderner 3-D-konformaler Technik\n                    zur Gewebeschonung durchgef\u00fchrt wird, eine sichere und effektive Therapie. In\n                    einer regelhaften Nachsorge sind Therapieeffekte und m\u00f6gliche Nebenwirkungen zu\n                    erfassen; insbesondere bei neurodegenerativen Erkrankungen ist die individuelle\n                    Dynamik der Symptomverschlechterung zu ber\u00fccksichtigen.<\/jats:p>","DOI":"10.1055\/a-0874-2406","type":"journal-article","created":{"date-parts":[[2019,6,5]],"date-time":"2019-06-05T22:41:13Z","timestamp":1559774473000},"page":"388-397","source":"Crossref","is-referenced-by-count":12,"title":["Hypersalivation \u2013 Aktualisierung der S2k-Leitlinie (AWMF)\n                    in gek\u00fcrzter Darstellung"],"prefix":"10.1055","volume":"98","author":[{"given":"Armin","family":"Steffen","sequence":"additional","affiliation":[{"name":"Universit\u00e4t zu L\u00fcbeck HNO-Klinik"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wolfgang","family":"Jost","sequence":"additional","affiliation":[{"name":"Universit\u00e4tsmedizin G\u00f6ttingen, HNO-Klinik"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tobias","family":"B\u00e4umer","sequence":"additional","affiliation":[{"name":"Universit\u00e4tsklinikum M\u00fcnster Klinik f\u00fcr Psychiatrie und\n                    Psychotherapie"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dirk","family":"Beutner","sequence":"additional","affiliation":[{"name":"Wissenschaftliches Institut f\u00fcr angewandte HNO-Heilkunde HNO-Praxis Bad\n                    Bramstedt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sabine","family":"Degenkolb-Weyers","sequence":"additional","affiliation":[{"name":"Curavid Praxis f\u00fcr Strahlentherapie Radiologie"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Gro\u00df","sequence":"additional","affiliation":[{"name":"Evangelische Hochschule Berlin Pflege- und\n                    Gesundheitswissenschaften"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Grosheva","sequence":"additional","affiliation":[{"name":"Phoniatrie Universit\u00e4tsklinikum Schleswig-Holstein"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samer","family":"Hakim","sequence":"additional","affiliation":[{"name":"Gemeinschaftspraxis Am Rosenplatz"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kai G.","family":"Kahl","sequence":"additional","affiliation":[{"name":"Dr. von Haunersches Kinderspital Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen\n                    P\u00e4diatrische Neurologie und Entwicklungsneurologie"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rainer","family":"Laskawi","sequence":"additional","affiliation":[{"name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen, Medizinische Fakult\u00e4t, Institut\n                    f\u00fcr Phonetik und Sprachverarbeitung"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rebekka","family":"Lencer","sequence":"additional","affiliation":[{"name":"Klinikum der Universit\u00e4t M\u00fcnchen, Klinik f\u00fcr Hals-, Nasen- und\n                    Ohrenheilkunde"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan","family":"L\u00f6hler","sequence":"additional","affiliation":[{"name":"Parkinson-Klinik Ortenau GmbH & Co. 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