{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,31]],"date-time":"2025-08-31T23:32:17Z","timestamp":1756683137580},"reference-count":27,"publisher":"Georg Thieme Verlag KG","issue":"05","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Exp Clin Endocrinol Diabetes"],"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n                        Background\/aim Prevention of hypoglycemia remains a major challenge\n                        in diabetic management, despite the introduction of modern insulin pumps in\n                        daily clinical practice. The Low Glucose Suspend (LGS) and the newer\n                        Predictive Low Glucose Management (PLGM) systems incorporated in the\n                        Medtronic insulin pumps have shown promising results in prevention of\n                        hypoglycemia. Our aim was to evaluate the effect of the 2 systems relative\n                        to the frequency of clinically significant hypoglycemia in Type 1 diabetes\n                        (T1DM). In addition, we investigated the events preceding clinically\n                        significant hypoglycemia episodes.<\/jats:p><jats:p>\n                        Methods A cross-sectional study was conducted in 30 T1DM patients\n                        using the MiniMed 640G vs. 30 using the MiniMed Veo sensor-augmented insulin\n                        pump. All data was recorded during patients\u2019 normal daily activity and\n                        living conditions. The patients were matched for age and duration of\n                        diabetes.<\/jats:p><jats:p>\n                        Results PLGM use was associated with lower incidence of clinically\n                        significant hypoglycemia (1.9\u00b11.4 vs. 3.6\u00b11.9 episodes per week), along with\n                        reduced exposure to hypoglycemia. The data indicated that both pump systems\n                        are effective in preventing severe hypoglycemic episodes. In both groups the\n                        most common events preceding hypoglycemic episodes included adjustment of\n                        hyperglycemia, basal rate increase and miscalculation of carbohydrates.<\/jats:p><jats:p>\n                        Conclusions The results indicated that the use of the Minimed 640G\n                        pump system can help reduce the frequency of clinically significant\n                        hypoglycemia. Management of hyperglycemia must be addressed in diabetes\n                        education programs in order to encourage proper adjustment of high blood\n                        glucose levels. Future studies would be useful in exploring the details of\n                        the events preceding hypoglycemia episodes in insulin pump users.<\/jats:p>","DOI":"10.1055\/a-0889-7598","type":"journal-article","created":{"date-parts":[[2019,4,15]],"date-time":"2019-04-15T23:04:43Z","timestamp":1555369483000},"page":"385-389","source":"Crossref","is-referenced-by-count":2,"title":["The Predictive Low Glucose Management System in Prevention of\n                    Clinically Significant Hypoglycemia in Type 1 Diabetes. A Preliminary Study\n                    Identifying the Most Common Events Leading Up to Hypoglycemia During Insulin\n                    Pump Therapy"],"prefix":"10.1055","volume":"129","author":[{"given":"Petros","family":"Thomakos","sequence":"additional","affiliation":[{"name":"Diabetes Center and Clinic, Hygeia General Hospital, Marousi, Athens,\n                    Greece"},{"name":"Department of Clinical Therapeutics, National and Kapodistrian\n                    University of Athens Alexandra Hospital, Athens, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Asimina","family":"Mitrakou","sequence":"additional","affiliation":[{"name":"Department of Clinical Therapeutics, National and Kapodistrian\n                    University of Athens Alexandra Hospital, Athens, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olga","family":"Kepaptsoglou","sequence":"additional","affiliation":[{"name":"Diabetes Center and Clinic, Hygeia General Hospital, Marousi, Athens,\n                    Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ibrahim","family":"Taraoune","sequence":"additional","affiliation":[{"name":"Diabetes Center and Clinic, Hygeia General Hospital, Marousi, Athens,\n                    Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carol","family":"Barreto","sequence":"additional","affiliation":[{"name":"Diabetes Center and Clinic, Hygeia General Hospital, Marousi, Athens,\n                    Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christos Sp.","family":"Zoupas","sequence":"additional","affiliation":[{"name":"Diabetes Center and Clinic, Hygeia General Hospital, Marousi, Athens,\n                    Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2019,4,15]]},"reference":[{"key":"ref1","first-page":"99","article-title":"Use and Effectiveness of Continuous 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