{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T02:11:10Z","timestamp":1782439870511,"version":"3.54.5"},"reference-count":15,"publisher":"Georg Thieme Verlag KG","issue":"05","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ultraschall Med"],"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Objective\u2002To evaluate the middle-term efficacy and complications of ultrasound-guided high intensity focused ultrasound (USgHIFU) for the treatment of symptomatic uterine fibroids in an NHS population.<\/jats:p><jats:p>\n          Methods\u2002A prospective observational single-center study at a single university hospital in Oxford, UK. Patients with symptomatic uterine fibroids who declined standard surgical\/radiological intervention and were referred to the HIFU unit were considered for USgHIFU treatment. Clinical evaluation, adverse event monitoring, uterine fibroid symptoms and health-related quality of life questionnaire (UFS-QOL) and contrast-enhanced pelvic magnetic resonance imaging (MRI) were performed before and at regular intervals after treatment to assess patient outcome.<\/jats:p><jats:p>\n          Results\u200212 of 22 referred patients underwent one session of USgHIFU ablation of 14 fibroids overall and received a two-year follow-up.\u200aNo serious adverse events were reported, but a second-degree skin burn was observed in one patient who had a surgical scar from a previous caesarean section. Mean symptom severity scores (SSS-QOL) improved significantly from 56.5\u200a\u00b1\u200a29.1 (SD) at baseline to 33.4\u200a\u00b1\u200a23.3 (p\u200a&lt;\u200a0.01) at three months, 45.0\u200a\u00b1\u200a35.4 (p\u200a&lt;\u200a0.05) at one year and 40.6\u200a\u00b1 32.7 (p\u200a&lt;\u200a0.01) at two years post-treatment. The mean non-perfused volume ratio was 67.7\u200a\u00b1\u200a39.0\u200a% (SD) in the treated fibroids (n\u200a=\u200a14) within three months of treatment. The mean volume reduction rates of the treated fibroids were 23.3\u200a\u00b1 25.5\u200a% (SD) at 3 months post-treatment (p\u200a&lt;\u200a0.01, n\u200a=\u200a14), 49.3\u200a\u00b1 23.7\u200a% at 12 months (p\u200a&lt;\u200a0.05, n\u200a=\u200a8), and 51.9\u200a\u00b1\u200a11.1\u200a% at 24\u00a0months (p\u200a&lt;\u200a0.005, n\u200a=\u200a8).<\/jats:p><jats:p>\n          Conclusion\u2002This study demonstrates the clinical efficacy of USgHIFU ablation of uterine fibroids and the low risk of complications. We believe that this noninvasive approach may offer an alternative therapy for women with symptomatic uterine fibroids. While HIFU is fast becoming the standard of care for fibroid ablation in other countries, to our knowledge, this study is the first to present clinical experience of US-guided HIFU ablation of symptomatic uterine fibroids in an NHS population.<\/jats:p><jats:p>\n          Plain Language Summary High intensity focused ultrasound (HIFU) can be used for the noninvasive ablation of symptomatic uterine fibroids, and MR-guided treatment has already gained FDA approval. Ultrasound-guided HIFU has the advantage of offering practicalities in anesthesia and considerable cost-savings over MR-guided treatments. In this prospective study we have demonstrated the middle-term efficacy and favorable safety profile of ultrasound-guided HIFU for the treatment of symptomatic uterine fibroids for the first time in an NHS population.<\/jats:p>","DOI":"10.1055\/a-0891-0729","type":"journal-article","created":{"date-parts":[[2019,6,25]],"date-time":"2019-06-25T22:38:55Z","timestamp":1561502335000},"page":"550-556","source":"Crossref","is-referenced-by-count":39,"title":["Ultrasound-Guided High Intensity Focused Ultrasound Ablation for\u00a0Symptomatic Uterine Fibroids: Preliminary Clinical Experience"],"prefix":"10.1055","volume":"41","author":[{"given":"Paul Christopher","family":"Lyon","sequence":"additional","affiliation":[{"name":"Clinical HIFU Unit, Oxford-University-Hospitals NHS Foundation Trust, Oxford, United Kingdom of Great Britain and Northern Ireland"},{"name":"Department of Radiology, Oxford-University-Hospitals NHS Foundation Trust, Oxford, United Kingdom of Great Britain and Northern Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vic","family":"Rai","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Oxford-University-Hospitals NHS Foundation Trust, Oxford, United Kingdom of Great Britain and Northern Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalia","family":"Price","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Oxford-University-Hospitals NHS Foundation Trust, Oxford, United Kingdom of Great Britain and Northern Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aarti","family":"Shah","sequence":"additional","affiliation":[{"name":"Department of Radiology, Oxford-University-Hospitals NHS Foundation Trust, Oxford, United Kingdom of Great Britain and Northern Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Wu","sequence":"additional","affiliation":[{"name":"Clinical HIFU Unit, Oxford-University-Hospitals NHS Foundation Trust, Oxford, United Kingdom of Great Britain and Northern Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Cranston","sequence":"additional","affiliation":[{"name":"Clinical HIFU Unit, Oxford-University-Hospitals NHS Foundation Trust, Oxford, United Kingdom of Great Britain and Northern Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2019,6,25]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1067\/mob.2003.99","article-title":"High cumulative incidence of uterine leiomyoma in black and white women: Ultrasound evidence","volume":"188","author":"D D Baird","year":"2003","journal-title":"Am J Obstet Gynecol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1016\/j.fertnstert.2007.12.004","article-title":"Uterine fibroid treatment patterns in a population of insured 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disease-specific symptom and health-related quality of life questionnaire for leiomyomata","volume":"99","author":"J B Spies","year":"2002","journal-title":"Obstet Gynecol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"2869","DOI":"10.1121\/1.421636","article-title":"Changes in ultrasonic images of tissue damaged by high\u2010intensity focused ultrasound in vivo","volume":"103","author":"F Wu","year":"1998","journal-title":"J Acoust Soc Am [Internet]"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1016\/j.ultrasmedbio.2008.01.012","article-title":"Hyperecho as the indicator of tissue necrosis during microbubble-assisted high intensity focused ultrasound: sensitivity, specificity and predictive value [Internet]","volume":"34","author":"T Yu","year":"2008","journal-title":"Ultrasound Med Biol"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"e571","DOI":"10.1016\/j.ejrad.2011.09.001","article-title":"Hyperecho in ultrasound images during high-intensity focused ultrasound ablation for hepatocellular carcinomas","volume":"80","author":"H Fukuda","year":"2011","journal-title":"Eur J Radiol"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"2943","DOI":"10.1245\/s10434-008-0032-x","article-title":"Ablation of high intensity focused ultrasound combined with SonoVue on rabbit VX2 liver tumors: Assessment with conventional gray-scale US, conventional color\/power doppler US, contrast-enhanced color doppler US, and contrast-enhanced pulse-inversion harm","volume":"15","author":"W Luo","year":"2008","journal-title":"Ann Surg Oncol"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1016\/j.ultrasmedbio.2005.03.015","article-title":"Hyperecho in ultrasound images of HIFU therapy: involvement of cavitation [Internet]","volume":"31","author":"B A Rabkin","year":"2005","journal-title":"Ultrasound Med Biol"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"1721","DOI":"10.1016\/j.ultrasmedbio.2006.04.010","article-title":"Biological and physical mechanisms of HIFU-induced hyperecho in ultrasound images","volume":"32","author":"B A Rabkin","year":"2006","journal-title":"Ultrasound Med Biol"}],"container-title":["Ultraschall in der Medizin - European Journal of 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