{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T20:25:28Z","timestamp":1772137528486,"version":"3.50.1"},"reference-count":31,"publisher":"Georg Thieme Verlag KG","issue":"06","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Exp Clin Endocrinol Diabetes"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\nBackground This study explores the association between chronic periodontitis and renal dysfunction in type 2 diabetic mellitus (T2DM) patients.<\/jats:p><jats:p>\nMethods An observational study was conducted in 169 T2DM patients with chronic periodontitis. Patients were divided into 2 groups according to presence of normal renal function (n=111) and renal dysfunction (n=58), and oral health behavior-related variables were obtained by questionnaire. Periodontal status was examined, and pocket probing depth (PD), clinical attachment level (CAL), and bleeding index (BI) were measured.<\/jats:p><jats:p>\nResults The severe periodontitis group had a significant higher HbA1c level (8.53 \u00b1 1.61%) as compared with the mild and moderate periodontitis groups (7.68\u00b11.58%) and (7.35\u00b11.45%), P=0.001. Compared with patients with normal renal function, patients with renal dysfunction had a higher PD value, higher CAL value, fewer remaining teeth, and were less likely to have remaining teeth \u226520. The percentage of sites with PD \u22654\u2009mm (52.8% vs. 41.67%) was significantly greater in patients with renal dysfunction. There was no difference in the scores of oral health knowledge assessment between the 2 groups. After adjustment by gender, age, BMI, smoking, hypertension, and HbA1c, the percentage of the sites with PD\u22654\u2009mm was an independent risk factor of renal dysfunction in T2DM patients.<\/jats:p><jats:p>\nConclusion In patients with T2DM, those with periodontitis may be more susceptible to decreased kidney function.<\/jats:p>","DOI":"10.1055\/a-0895-5275","type":"journal-article","created":{"date-parts":[[2019,5,2]],"date-time":"2019-05-02T23:11:58Z","timestamp":1556838718000},"page":"407-412","source":"Crossref","is-referenced-by-count":7,"title":["Chronic Periodontitis is a Risk Factor of Renal Dysfunction in Patients with Type 2 Diabetes"],"prefix":"10.1055","volume":"129","author":[{"given":"Dongxue","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Stomatology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenyan","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Stomatology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ran","family":"Miao","sequence":"additional","affiliation":[{"name":"Medical Research Center, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lei","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Stomatology, Chuiyangliu Hospital, Tsinghua University, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuan","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Stomatology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haiyan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Stomatology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yufeng","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Beijing Friendship Hospital Pinggu Campus, Capital Medical University, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zuomin","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Stomatology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2019,5,2]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/j.expneurol.2007.05.014","article-title":"CNS injury, glial scars, and inflammation: Inhibitory extracellular matrices and regeneration failure","volume":"209","author":"M T Fitch","year":"2008","journal-title":"Exp Neurol"},{"key":"ref2","first-page":"49","article-title":"Diabetic kidney disease: World wide difference of prevalence and risk factors","volume":"5","author":"O Gheith","year":"2016","journal-title":"J Nephropharmacol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.diabres.2011.10.029","article-title":"IDF diabetes atlas: Global estimates of the prevalence of diabetes for 2011 and 2030","volume":"94","author":"D R Whiting","year":"2011","journal-title":"Diabetes Res Clin Pract"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"S105","DOI":"10.2337\/dc18-S010","article-title":"10. 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