{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T01:38:55Z","timestamp":1772761135240,"version":"3.50.1"},"reference-count":0,"publisher":"Georg Thieme Verlag KG","issue":"09\/10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Planta Med"],"published-print":{"date-parts":[[2019,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Chromatographic separation of extracts from the fungal biomass of a plant pathogenic fungus, Myrothecium roridum, yielded 8 trichothecene toxins including 6 type D trichothecenes (1\u20136) and 2 type A trichothecenes (7\u20138). 6\u2032,12\u2032-Epoxymyrotoxin A (1) and 7\u2032-hydroxymytoxin B (2) were new macrocyclic trichothecenes, while the other trichothecenes were identified as myrotoxin B (3), myrotoxin D hydrate (4), 2\u2032,3\u2032-epoxymyrothecine A (5), miotoxin A (6), and 2 trichothecenes lacking the macrocyclic lactone system, roridin L-2 (7) and trichoverritone (8). The structures of these mycotoxins were characterized using spectroscopic methods. The absolute configurations of 1 and 2 were determined by NOESY and a comparison of their experimental and calculated ECD spectra. Most of these mycotoxins (1\u20134 and 6) exhibited highly potent antimalarial activity against Plasmodium falciparum. They also showed strong cytotoxicity towards KB and NCI-H187 cell lines (IC50 0.60\u200a\u2013\u200a112.28\u2009nM), as well as the Vero cell line (IC50 1.50\u200a\u2013\u200a46.51\u2009nM).<\/jats:p>","DOI":"10.1055\/a-0895-5753","type":"journal-article","created":{"date-parts":[[2019,4,26]],"date-time":"2019-04-26T23:53:09Z","timestamp":1556322789000},"page":"774-780","source":"Crossref","is-referenced-by-count":11,"title":["Types A and D Trichothecene Mycotoxins from the Fungus Myrothecium roridum"],"prefix":"10.1055","volume":"85","author":[{"given":"Waranya","family":"Lakornwong","sequence":"additional","affiliation":[{"name":"Natural Products Research Unit, Department of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science, Khon Kaen University, Khon Kaen, Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kwanjai","family":"Kanokmedhakul","sequence":"additional","affiliation":[{"name":"Natural Products Research Unit, Department of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science, Khon Kaen University, Khon Kaen, Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kasem","family":"Soytong","sequence":"additional","affiliation":[{"name":"Department of Plant Production Technology, Faculty of Agricultural Technology, King Mongkut\u02bcs Institute of Technology Ladkrabang, Bangkok, Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arm","family":"Unartngam","sequence":"additional","affiliation":[{"name":"Bioproduct Science, Department of Science, Faculty of Liberal Arts and Science, Kasetsart University Kamphaeng Saen Campus, Nakorn Pathom, Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarawut","family":"Tontapha","sequence":"additional","affiliation":[{"name":"Integrated Nanotechnology Research Center, Department of Physics, Faculty of Science, Khon Kaen University, Khon Kaen, Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vittaya","family":"Amornkitbamrung","sequence":"additional","affiliation":[{"name":"Integrated Nanotechnology Research Center, Department of Physics, Faculty of Science, Khon Kaen University, Khon Kaen, Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Somdej","family":"Kanokmedhakul","sequence":"additional","affiliation":[{"name":"Natural Products Research Unit, Department of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science, Khon Kaen University, Khon Kaen, Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2019,4,26]]},"container-title":["Planta Medica"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-0895-5753.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,7,1]],"date-time":"2019-07-01T22:35:09Z","timestamp":1562020509000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-0895-5753"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,4,26]]},"references-count":0,"journal-issue":{"issue":"09\/10","published-online":{"date-parts":[[2019,7,1]]},"published-print":{"date-parts":[[2019,7]]}},"URL":"https:\/\/doi.org\/10.1055\/a-0895-5753","relation":{},"ISSN":["0032-0943","1439-0221"],"issn-type":[{"value":"0032-0943","type":"print"},{"value":"1439-0221","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,4,26]]}}}