{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T22:42:07Z","timestamp":1773960127656,"version":"3.50.1"},"reference-count":0,"publisher":"Georg Thieme Verlag KG","issue":"03","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Exp Clin Endocrinol Diabetes"],"published-print":{"date-parts":[[2020,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\nBackground Adipokines derived from adipocytes are one of the important\nfactors that act as circulating regulators of bone metabolism. Complement\nC1q\/tumor necrosis factor-related protein-3 (CTRP3), a paralog of\nadiponectin, is are member of the CTRP superfamily. The aim of this study was to\ninvestigate the role of serum CTRP3 in the development of osteoporosis in\npatients with primary hyperparathyroidism.<\/jats:p><jats:p>\nMethods This study included 53 patients with diagnosed primary\nhyperparathyroidism and 30 healthy controls. Laboratory tests for the diagnosis\nof primary hyperparathyroidism and serum levels of CTRP3 measured for all\npatients. Bone mineral density was obtained on lumbar spine 1 and 4 by dual\nenergy X-ray absorptiometry.<\/jats:p><jats:p>\nResults Serum CTRP3 levels were lower in patients with primary\nhyperparathyroidism than in the control group (p&lt;0.001). In addition,\nprimary hyperparathyroidism patients are were divided into two groups as, with\nand without osteoporosis; the levels of CTRP3 were lower in patients with\nosteoporosis than in patients without osteoporosis (p=0.004). In\nlogistic regression analysis, only CTRP3 levels independently determined the\npatients to be osteoporosis (p&lt;0.05). According to this analysis,\ndecreased CTRP3 (per 1\u2009ng\/mL) levels were found to increase the\nrisk of patients for osteoporosis by 6.9%. When the CTRP3 cut-off values\nwere taken as 30\u2009ng\/mL, it determined osteoporosis with\n76.4% sensitivity and 73.2% specificity. CTRP3 and urine calcium\nlevels were independently associated with T score in dual energy X-ray\nabsorptiometry.<\/jats:p><jats:p>\nConclusions CTRP3 levels were significantly decreased in patients with\nprimary hyperparathyroidism, and it is also related to osteoporosis.<\/jats:p>","DOI":"10.1055\/a-0899-5210","type":"journal-article","created":{"date-parts":[[2019,5,22]],"date-time":"2019-05-22T22:48:10Z","timestamp":1558565290000},"page":"152-157","source":"Crossref","is-referenced-by-count":7,"title":["CTRP3 is Significantly Decreased in Patients with Primary Hyperparathyroidism and Closely Related with Osteoporosis"],"prefix":"10.1055","volume":"128","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9449-8759","authenticated-orcid":false,"given":"Derya","family":"Demirtas","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University of Health Sciences - Adana\nHealth Practice and Research Center, Adana, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2252-2112","authenticated-orcid":false,"given":"Fettah","family":"Ac\u0131bucu","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Endocrinology Division, University of\nHealth Sciences - Adana Health Practice and Research Center, Adana,\nTurkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3117-7768","authenticated-orcid":false,"given":"Filiz Alkan","family":"Baylan","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, University of Sutcu Imam- Kahramanmaras,\nTurkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0026-2396","authenticated-orcid":false,"given":"Erdinc","family":"Gulumsek","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University of Health Sciences - Adana\nHealth Practice and Research Center, Adana, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5588-5609","authenticated-orcid":false,"given":"Tayyibe","family":"Saler","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University of Health Sciences - Adana\nHealth Practice and Research Center, Adana, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2019,5,22]]},"container-title":["Experimental and Clinical Endocrinology &amp; Diabetes"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-0899-5210.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,3,4]],"date-time":"2020-03-04T23:50:32Z","timestamp":1583365832000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-0899-5210"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5,22]]},"references-count":0,"journal-issue":{"issue":"03","published-online":{"date-parts":[[2020,3,4]]},"published-print":{"date-parts":[[2020,3]]}},"URL":"https:\/\/doi.org\/10.1055\/a-0899-5210","relation":{},"ISSN":["0947-7349","1439-3646"],"issn-type":[{"value":"0947-7349","type":"print"},{"value":"1439-3646","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,5,22]]}}}