{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T04:15:55Z","timestamp":1769055355113,"version":"3.49.0"},"reference-count":37,"publisher":"Georg Thieme Verlag KG","issue":"01","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ultraschall Med"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Purpose\u2002Children with congenital heart disease (CHD) are known to have impaired neurodevelopment possibly influenced by altered cerebroplacental hemodynamics antenatally. We compared fetomaternal Doppler patterns in different CHD groups with published normative values during gestation.<\/jats:p><jats:p>Materials and Methods\u2002Retrospective cohort study consisting of 248 CHD fetuses. Subgroups were generated according to the expected ascending aorta oxygen saturation: low portion of high oxygenated umbilical venous (UV) blood (group 1: n\u200a=\u200a108), intermediate portion of UV blood due to intracardiac mixing with oxygen poor systemic blood (group 2: n\u200a=\u200a103), high (group 3: n\u200a=\u200a13) and low portion of UV blood without mixing of blood (group 4: n\u200a=\u200a24). Doppler examination included umbilical artery and middle cerebral artery pulsatility index (UA-PI, MCA-PI), cerebroplacental ratio (CPR) and mean uterine artery (mUtA) PI. For mean comparisons at different gestational ages (GA), estimated marginal means from regression models are reported for GA 22 weeks (wks), GA 30 wks and GA 38 wks.<\/jats:p><jats:p>Results\u2002Z-score transformed values of MCA-PI (zMCA-PI) were significantly lower in group 1 compared to all other subgroups at GA 30 wks (p\u200a&lt;\u200a0.05). At 38 wks, group 1 had significantly lower values of zMCA-PI and zCPR compared to groups 2 and 4. Group 1 fetuses showed a significant association between zMCA-PI and zCPR (negative) and GA as well as zmUtA-PI (positive) and GA compared to reference values.<\/jats:p><jats:p>Conclusion\u2002Our data confirm that CHD fetuses have a higher rate of cerebral redistribution in the third trimester. Changes in Doppler patterns were mainly observed in CHD with a low portion of UV blood in the ascending aorta.<\/jats:p>","DOI":"10.1055\/a-0900-4021","type":"journal-article","created":{"date-parts":[[2019,6,14]],"date-time":"2019-06-14T22:40:41Z","timestamp":1560552041000},"page":"48-55","source":"Crossref","is-referenced-by-count":6,"title":["Cerebroplacental and Uterine Doppler Indices in Pregnancies Complicated by Congenital Heart Disease of the Fetus"],"prefix":"10.1055","volume":"42","author":[{"given":"Oliver","family":"Graupner","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, University Hospital rechts der Isar, Technical University of Munich, Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jessica","family":"Koch","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Division of Prenatal Medicine, University Hospital UKGM, Justus-Liebig University, Giessen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Enzensberger","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Division of Prenatal Medicine, University Hospital UKGM, Justus-Liebig University, Giessen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Malena","family":"G\u00f6tte","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Division of Prenatal Medicine, University Hospital UKGM, Justus-Liebig University, Giessen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aline","family":"Wolter","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Division of Prenatal Medicine, University Hospital UKGM, Justus-Liebig University, Giessen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vera","family":"M\u00fcller","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Division of Prenatal Medicine, University Hospital UKGM, Justus-Liebig University, Giessen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreea","family":"Kawecki","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Division of Prenatal Medicine, University Hospital UKGM, Justus-Liebig University, Giessen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johannes","family":"Herrmann","sequence":"additional","affiliation":[{"name":"Statistical Consulting Service Giessen, Giessen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roland","family":"Axt-Fliedner","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Division of Prenatal Medicine, University Hospital UKGM, Justus-Liebig University, Giessen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2019,6,14]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.jpeds.2005.08.036","article-title":"Long-term neuromotor outcome at school entry of infants with congenital heart defects requiring open-heart surgery","volume":"148","author":"A Majnemer","year":"2006","journal-title":"J Pediatr"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1067\/mpd.2000.109152","article-title":"Neurodevelopmental status of newborns and infants with congenital heart defects before and after open heart surgery","volume":"137","author":"C Limperopoulos","year":"2000","journal-title":"J Pediatr"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1155\/2010\/359390","article-title":"Impact of congenital heart disease on brain development and 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The results of a worldwide survey of experts\u2019 attitudes advise caution","volume":"47","author":"D Paladini","year":"2016","journal-title":"Ultrasound Obstet Gynecol"}],"container-title":["Ultraschall in der Medizin - European Journal of Ultrasound"],"original-title":[],"language":"de","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-0900-4021.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,9,20]],"date-time":"2022-09-20T21:17:18Z","timestamp":1663708638000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-0900-4021"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,6,14]]},"references-count":37,"journal-issue":{"issue":"01","published-online":{"date-parts":[[2021,2,2]]},"published-print":{"date-parts":[[2021,2]]}},"URL":"https:\/\/doi.org\/10.1055\/a-0900-4021","relation":{},"ISSN":["0172-4614","1438-8782"],"issn-type":[{"value":"0172-4614","type":"print"},{"value":"1438-8782","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,6,14]]}}}