{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T21:22:33Z","timestamp":1790716953511,"version":"4.1.0"},"reference-count":0,"publisher":"Georg Thieme Verlag KG","issue":"06","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Horm Metab Res"],"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Hypoparathyroidism is a rare endocrine disease with insufficient parathyroid hormone levels. Replacing the missing hormone is not yet a standard therapy. The objective of this retrospective cohort study was to evaluate if the usual therapy regimens of postsurgical hypoparathyroidism with calcitriol have a negative effect on renal function. We performed a chart analysis of patients who were seen in a tertiary care hospital in Brussels, Belgium. A total of 101 subjects were identified as patients with permanent post-surgical hypoparathyroidism, based on the hospital records of patients who underwent a total thyroidectomy between 1996 and 2016, while still being treated with calcitriol. Patients with pre-existing renal insufficiency and\/or active malignancy were excluded. The cohort was predominantly female of Caucasian origin. Renal function was evaluated before and after surgery (with a maximum follow-up of 12 years), using the CKD-EPI equation. A multivariate linear regression model was used to correlate renal function decline with the duration of calcitriol therapy, while correcting for the mean calcium phosphate product and age. We found a statistically significant (p=0.027) relationship between the duration of calcitriol treatment and renal function decline at a rate of 1.06\u2009ml\/min\/1.73\u2009m2 per year of calcitriol therapy. Our study, although being retrospective, is the first one to demonstrate a relationship between the cumulative use of calcitriol therapy and renal function decline.<\/jats:p>","DOI":"10.1055\/a-0902-8476","type":"journal-article","created":{"date-parts":[[2019,6,17]],"date-time":"2019-06-17T18:31:10Z","timestamp":1560796270000},"page":"362-366","source":"Crossref","is-referenced-by-count":17,"title":["Long-Term Treatment with Calcitriol in Postsurgical Hypoparathyroidism Leads to Renal Function Decline"],"prefix":"10.1055","volume":"51","author":[{"given":"Elien","family":"Coudenys","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, UZ Brussel, Vrije Universiteit Brussel (VUB), Jette, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tess","family":"Van Meerhaeghe","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Erasmus Ziekenhuis, Universit\u00e9 Libre de Bruxelles (ULB), Bruxelles, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Unuane","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, UZ Brussel, Vrije Universiteit Brussel (VUB), Jette, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald","family":"Buyl","sequence":"additional","affiliation":[{"name":"Department of Statistics, Vrije Universiteit Brussel (VUB), Jette, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bert","family":"Bravenboer","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, UZ Brussel, Vrije Universiteit Brussel (VUB), Jette, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2019,6,17]]},"container-title":["Hormone and Metabolic Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-0902-8476.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,10]],"date-time":"2019-09-10T19:12:31Z","timestamp":1568142751000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-0902-8476"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,6]]},"references-count":0,"journal-issue":{"issue":"06","published-online":{"date-parts":[[2019,6,17]]},"published-print":{"date-parts":[[2019,6]]}},"URL":"https:\/\/doi.org\/10.1055\/a-0902-8476","relation":{},"ISSN":["0018-5043","1439-4286"],"issn-type":[{"value":"0018-5043","type":"print"},{"value":"1439-4286","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,6]]}}}