{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,14]],"date-time":"2025-10-14T07:09:06Z","timestamp":1760425746617,"version":"3.37.3"},"reference-count":0,"publisher":"Georg Thieme Verlag KG","issue":"01","funder":[{"DOI":"10.13039\/501100004733","name":"University of Macau","doi-asserted-by":"crossref","award":["(SRG2014\u201300019-FHS; MYRG2015\u201300230-FHS; MYRG2016\u201300005-FHS)"],"award-info":[{"award-number":["(SRG2014\u201300019-FHS; MYRG2015\u201300230-FHS; MYRG2016\u201300005-FHS)"]}],"id":[{"id":"10.13039\/501100004733","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100009331","name":"Beijing Municipal Administration of Hospitals Clinical Medicine Development of Special Funding Support","doi-asserted-by":"crossref","award":["(ZYLX201807, XLMX201807)"],"award-info":[{"award-number":["(ZYLX201807, XLMX201807)"]}],"id":[{"id":"10.13039\/501100009331","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Capital\u2019s Funds for Health Improvement and Research","award":["(2018-2-2123)"],"award-info":[{"award-number":["(2018-2-2123)"]}]},{"name":"Major Science and Technology Award of the Science and Technology Department of Guangdong Province","award":["(2016B010108003)"],"award-info":[{"award-number":["(2016B010108003)"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmacopsychiatry"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\nBackground Results of previous studies on the safety and efficacy of adjunctive reboxetine for schizophrenia have been inconsistent.<\/jats:p><jats:p>\nAim The aim of this study was to examine the efficacy and tolerability of reboxetine as an adjunct medication to antipsychotic treatment in a meta-analysis of randomized controlled trials (RCTs).<\/jats:p><jats:p>\nMethods Two independent investigators extracted data for a random effects meta-analysis and assessed the quality of studies using risk of bias and the Jadad scale. Weighted and standardized mean differences (WMDs\/SMDs) and risk ratio (RR)\u00b195% confidence intervals (CIs) were calculated.<\/jats:p><jats:p>\nResults Nine RCTs (n=630) with double-blind design were identified. Reboxetine outperformed placebo in improving negative (9 RCTs, n=602, SMD: \u22120.47 [95% CI: \u22120.87, \u22120.07], p=0.02; I2=82%), but not the overall, positive, and general psychopathology scores. The significant therapeutic effect on negative symptoms disappeared in the sensitivity analysis after removing an outlying study and in 50% (6\/12) of the subgroup analyses. Reboxetine outperformed placebo in reducing weight (3 RCTs, n=186, WMD: \u22123.83\u2009kg, p=0.04; I2=92%) and body mass index (WMD: \u22122.23\u2009kg\/m2, p=0.04; I2=95%). Reboxetine caused dry mouth but was associated with less weight gain overall and weight gain of \u22657% of the initial weight. All-cause discontinuation and other adverse events were similar between reboxetine and placebo.<\/jats:p><jats:p>\nConclusion Adjunctive reboxetine could be useful for attenuating antipsychotic-induced weight gain, but it was not effective in treating psychopathology including negative symptoms in schizophrenia.<\/jats:p>","DOI":"10.1055\/a-0914-3260","type":"journal-article","created":{"date-parts":[[2019,6,17]],"date-time":"2019-06-17T18:58:30Z","timestamp":1560797910000},"page":"5-13","source":"Crossref","is-referenced-by-count":4,"title":["Adjunctive Reboxetine for Schizophrenia: Meta-analysis of Randomized Double-blind, Placebo-controlled Trials"],"prefix":"10.1055","volume":"53","author":[{"given":"Wei","family":"Zheng","sequence":"additional","affiliation":[{"name":"The Affiliated Brain Hospital of Guangzhou Medical University (Guangzhou Huiai Hospital), Guangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xian-Bin","family":"Li","sequence":"additional","affiliation":[{"name":"The National Clinical Research Center for Mental Disorders & Beijing Key Laboratory of Mental Disorders, Beijing Anding Hospital & the Advanced Innovation Center for Human Brain Protection, Capital Medical University, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhan-Ming","family":"Shi","sequence":"additional","affiliation":[{"name":"Chongqing Jiangbei Mental Health Center, Chongqing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin-Hu","family":"Yang","sequence":"additional","affiliation":[{"name":"The Affiliated Brain Hospital of Guangzhou Medical University (Guangzhou Huiai Hospital), Guangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dong-Bin","family":"Cai","sequence":"additional","affiliation":[{"name":"Shenzhen Traditional Chinese Medicine Hospital, Shenzhen, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chee H.","family":"Ng","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, University of Melbourne, Melbourne, Victoria, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabor S.","family":"Ungvari","sequence":"additional","affiliation":[{"name":"The University of Notre Dame Australia, Fremantle, Australia"},{"name":"Division of Psychiatry, School of Medicine, University of Western Australia, Perth, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei-Jian","family":"Liu","sequence":"additional","affiliation":[{"name":"The Affiliated Brain Hospital of Guangzhou Medical University (Guangzhou Huiai Hospital), Guangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu-Jie","family":"Wu","sequence":"additional","affiliation":[{"name":"The Affiliated Brain Hospital of Guangzhou Medical University (Guangzhou Huiai Hospital), Guangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuan-Yuan","family":"Wang","sequence":"additional","affiliation":[{"name":"Faculty of Health and Life Sciences, De Montfort University, Leicester, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu-Ping","family":"Ning","sequence":"additional","affiliation":[{"name":"The Affiliated Brain Hospital of Guangzhou Medical University (Guangzhou Huiai Hospital), Guangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu-Tao","family":"Xiang","sequence":"additional","affiliation":[{"name":"Unit of Psychiatry, Institute of Translational Medicine, Faculty of Health Sciences, University of Macau, Macao SAR, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2019,6,17]]},"container-title":["Pharmacopsychiatry"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-0914-3260.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,1,9]],"date-time":"2020-01-09T18:31:15Z","timestamp":1578594675000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-0914-3260"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,6,17]]},"references-count":0,"journal-issue":{"issue":"01","published-online":{"date-parts":[[2020,1,9]]},"published-print":{"date-parts":[[2020,1]]}},"URL":"https:\/\/doi.org\/10.1055\/a-0914-3260","relation":{},"ISSN":["0176-3679","1439-0795"],"issn-type":[{"type":"print","value":"0176-3679"},{"type":"electronic","value":"1439-0795"}],"subject":[],"published":{"date-parts":[[2019,6,17]]}}}