{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,3,25]],"date-time":"2024-03-25T18:09:58Z","timestamp":1711390198815},"reference-count":0,"publisher":"Georg Thieme Verlag KG","issue":"19","license":[{"start":{"date-parts":[[2019,7,5]],"date-time":"2019-07-05T00:00:00Z","timestamp":1562284800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dtsch med Wochenschr"],"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title><jats:p>Die Ende 2015 ver\u00f6ffentlichten ESC\/ERS-Leitlinien und andere internationale Empfehlungen definierten die pulmonale Hypertonie (PH) bisher durch einen invasiv gemessenen mittleren pulmonal arteriellen Druck (mPAP) \u2265\u200a25\u200ammHg in Ruhe. Auf dem 6th World Symposium on Pulmonary Hypertension in Nizza wurde eine Modifikation dieser h\u00e4modynamischen Definition im Sinne einer Senkung des Schwellenwertes auf &gt;\u200a20\u200ammHg vorgeschlagen. F\u00fcr die pr\u00e4kapill\u00e4re PH wird zus\u00e4tzlich ein pulmonaler Gef\u00e4\u00dfwiderstand (PVR) \u2265\u200a3\u00a0Wood-Einheiten (WE) gefordert. Diese \u00c4nderung muss im Hinblick auf die zugrunde liegende Rationale und m\u00f6gliche Konsequenzen kritisch hinterfragt werden; es bedarf daher einer eingehenden Erl\u00e4uterung. Insbesondere muss klargestellt werden, dass diese \u00c4nderung aktuell keinen Einfluss auf die evidenzbasierte und zulassungskonforme Verschreibung von Medikamenten zur gezielten Therapie der pulmonal arteriellen Hypertonie (PAH) hat.<\/jats:p>","DOI":"10.1055\/a-0918-3772","type":"journal-article","created":{"date-parts":[[2019,7,5]],"date-time":"2019-07-05T19:35:26Z","timestamp":1562355326000},"page":"1367-1372","source":"Crossref","is-referenced-by-count":9,"title":["H\u00e4modynamische Definition der pulmonalen Hypertonie: Kommentar zu der vorgeschlagenen \u00c4nderung durch das 6th World\u00a0Symposium on Pulmonary Hypertension"],"prefix":"10.1055","volume":"144","author":[{"given":"Stephan","family":"Rosenkranz","sequence":"additional","affiliation":[{"name":"Klinik III f\u00fcr Innere Medizin und Cologne Cardiovascular Research Center (CCRC), Herzzentrum der Universit\u00e4t zu K\u00f6ln"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerhard-Paul","family":"Diller","sequence":"additional","affiliation":[{"name":"Department f\u00fcr Kardiologie und Angiologie, Klinik f\u00fcr angeborene (EMAH) und erworbene Herzfehler, Universit\u00e4tsklinikum M\u00fcnster"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Dumitrescu","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Allgemeine und Interventionelle Kardiologie, Herz- und Diabeteszentrum NRW, Bad Oeynhausen"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ralf","family":"Ewert","sequence":"additional","affiliation":[{"name":"Klinik und Poliklinik f\u00fcr Innere Medizin, Pneumologie\/Infektiologie, Universit\u00e4tsklinik Greifswald"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H. Ardeschir","family":"Ghofrani","sequence":"additional","affiliation":[{"name":"Abteilung Pneumologie, Medizinische Klink II, Universit\u00e4tsklinikum Gie\u00dfen und Marburg, Universities of\u00a0Giessen and Marburg Lung Center (UGMLC), Standort\u00a0Gie\u00dfen"},{"name":"Department of Medicine, Imperial College, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ekkehard","family":"Gr\u00fcnig","sequence":"additional","affiliation":[{"name":"Zentrum f\u00fcr pulmonale Hypertonie, Thoraxklinik am Universit\u00e4tsklinikum Heidelberg"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Halank","sequence":"additional","affiliation":[{"name":"Medizinische Klinik I, Universit\u00e4tsklinik Carl Gustav Carus, TU Dresden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthias","family":"Held","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Innere Medizin, Abt. 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