{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T13:50:36Z","timestamp":1786974636705,"version":"build-2736575974"},"reference-count":36,"publisher":"Georg Thieme Verlag KG","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Exp Clin Endocrinol Diabetes"],"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n                        Purpose It is assumed that primary hyperparathyroidism (pHPT) in\n                        Multiple Endocrine Neoplasia (MEN) and lithium-associated pHPT (LIHPT) are\n                        associated with multiple gland disease (MGD), persistence and recurrence.\n                        The studies purpose was to determine frequencies, clinical presentation and\n                        outcome of sporadic pHPT (spHPT), LIHPT and pHPT in MEN. Additional main\n                        outcome measures were the rates of MGD and\n                        persistence\/recurrence.<\/jats:p><jats:p>\n                        Methods Retrospective analysis of medical records of 682 patients\n                        with pHPT who had attended the University Hospital of Marburg between\n                        01\u201301\u20132004 and 30\u201306\u20132013. All patients were\n                        sent a questionnaire asking about their history of lithium medication.<\/jats:p><jats:p>\n                        Results Out of 682 patients, 557 underwent primary surgery (532\n                        spHPT, 5 LIHPT, 20 MEN), 38 redo-surgery (31 spHPT, 7 MEN), 55 were in\n                        follow-up due to previous surgery (16 spHPT, 1 LIHPT, 38 MEN) and 37 were\n                        not operated (33 spHPT, 1 LIHPT, 3 MEN). Primary surgeries were successful\n                        in 97.4%, revealed singular adenomas in 92.4%, double\n                        adenomas in 2.9% and MGD in 3.4% of the cases. Rates of MGD\n                        in MEN1 (82.35%) were significantly higher than in spHPT\n                        (3.8%), while there was no significant difference between LIHPT\n                        (20%) and spHPT. Rates of persistence\/recurrence did not\n                        significantly differ due to type of surgery (bilateral\/unilateral)\n                        or type of HPT (spHPT\/LIHPT\/MEN).<\/jats:p><jats:p>\n                        Conclusions History of lithium medication is rare among pHPT\n                        patients. While MGD is common in MEN1, rates of MGD, persistence or\n                        recurrence in LIHPT were not significantly higher than in spHPT.<\/jats:p>","DOI":"10.1055\/a-0950-9892","type":"journal-article","created":{"date-parts":[[2019,8,14]],"date-time":"2019-08-14T22:54:30Z","timestamp":1565823270000},"page":"693-698","source":"Crossref","is-referenced-by-count":5,"title":["Single Centre Experience in Patients with Primary\n                    Hyperparathyroidism: Sporadic, Lithium-associated and in Multiple Endocrine\n                    Neoplasia"],"prefix":"10.1055","volume":"128","author":[{"given":"Sabine","family":"Dillenberger","sequence":"additional","affiliation":[{"name":"Centre for Endocrinology, Diabetology & Osteology,\n                    Philipp\u2019s University Marburg, Marburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Detlef K.","family":"Bartsch","sequence":"additional","affiliation":[{"name":"Department of Visceral-, Thoracic- and Vascular Surgery,\n                    Philipp\u2019s University Marburg, Marburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabeth","family":"Maurer","sequence":"additional","affiliation":[{"name":"Department of Visceral-, Thoracic- and Vascular Surgery,\n                    Philipp\u2019s University Marburg, Marburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter Herbert","family":"Kann","sequence":"additional","affiliation":[{"name":"Centre for Endocrinology, Diabetology & Osteology,\n                    Philipp\u2019s University Marburg, Marburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2019,8,14]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1016\/S0140-6736(96)06176-4","article-title":"Primary hyperparathyroidism","volume":"349","author":"A A 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Diabetes"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-0950-9892.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,10,7]],"date-time":"2020-10-07T22:51:04Z","timestamp":1602111064000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-0950-9892"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,8,14]]},"references-count":36,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2020,10,7]]},"published-print":{"date-parts":[[2020,10]]}},"URL":"https:\/\/doi.org\/10.1055\/a-0950-9892","relation":{},"ISSN":["0947-7349","1439-3646"],"issn-type":[{"value":"0947-7349","type":"print"},{"value":"1439-3646","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,8,14]]}}}